Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Computed Properties of 60-56-0.
Pravikova, P. D.;Ivanova, L. N. research published 《 Effect of NO Synthesis Blockade on Renal Osmoregulatory Function in Methimazole-Induced Hypothyroid Rats with Different Vasopressin Blood Level》, the research content is summarized as follows. We studied the effect of blockade of NO synthesis on the renal osmoregulatory function in methimazole-induced hypothyroid WAG and vasopressin-deficient Brattleboro rats. It was established that NO modulates the hydroosmotic effect of vasopressin by affecting the parameters of the renal hydruretic function regardless of blood levels of thyroid hormones. At the same time, it was found that NO plays a considerable role in the development of antinatriuresis under conditions of inhibited thyroid hormone synthesis, with this effect being independent of the endogenous vasopressin blood level. In WAG and vasopressin-deficient Brattleboro rats, methimazole-induced hypothyroidism promoted the development of antinatriuresis, while the elimination of the NO effect against the background of thyroid hormone synthesis blockade led to the development of natriuresis. These results indicate a significant role of NO in the suppression of sodium excretion in hypothyroidism. The possible mechanisms underlying the effect of NO on the parameters of renal natriuretic function in WAG and Brattleboro rats under conditions of suppressed thyroid hormone synthesis are discussed.
60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Computed Properties of 60-56-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem