On April 1, 2020, Hilton-Proctor, J. P.; Ilyichova, O.; Zheng, Z.; Jennings, I. G.; Johnstone, R. W.; Shortt, J.; Mountford, S. J.; Scanlon, M. J.; Thompson, P. E. published an article.Formula: C6H11N3 The title of the article was Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors. And the article contained the following:
The synthesis of a 4-Ph substituted analog – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives I (R = H, Br, Ph, 2-phenylethyl, etc.; R1 = 2-Br, 4-Ph, morpholine-4-sulfonyl, etc.) were described. Ultimately, this has led to structurally complex, chiral compounds (R/S)-II (R2 = H, Me; R3 = H, 3,4-dimethoxyphenyl; R4 = H, N,N-diethylsulfamoyl) with progressively improved affinity as inhibitors of bromodomain-containing protein 4. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3
The Article related to methyl phenylpyrrolidinone preparation bromodomain inhibitor, brd4, bromodomain, epigenetics, fragment-based drug design, k-ac, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Formula: C6H11N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem