Aliakbar Tehrani, Zahra; Torabifard, Hedieh; Fattahi, Alireza published an article in 2012, the title of the article was Thermochemical properties of some vinyl chloride-induced DNA lesions: detailed view from NBO & AIM analysis.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:
Etheno-damaged DNA adducts such as 3,N4-ethenocytosine, N2,3-ethenoguanine, and 1,N2-ethenoguanine are associated with carcinogenesis and cell death. These inevitable damages are counteracted by glycosylase enzymes, which cleave damaged nucleobases from DNA. Escherichia coli alkyl purine DNA glycosylase is the enzyme responsible for excising damaged etheno adducts from DNA in humans. In an effort to understand the intrinsic properties of these mols., we examined gas-phase acidity values and proton affinities (PA) of multiple sites of these mols. as well as equilibrium tautomerization and base pairing properties by quantum mech. calculations We also used calculations to compare the acidic and basic properties of these etheno adduct with those of the normal bases-cytosine and guanine nucleobases. We hypothesize that alkyl DNA glycosylase may cleave certain damaged nucleobases as anions and that the active site may take advantage of a nonpolar environment to favor deprotonated cytosine or guanine as a leaving group vs. damaged nucleobases. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one
The Article related to dna damage thermochem property ethenocytosine ethenoguanine, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem