War, Javeed Ahmad; Srivastava, Santosh Kumar published an article in 2020, the title of the article was Rationale design and synthesis of some novel imidazole linked thiazolidinone hybrid molecules as DNA minor groove binders.Application In Synthesis of N-(3-Aminopropyl)-imidazole And the article contains the following content:
A new series of imidazole linked thiazolidinone hybrid mols. was designed and subsequently synthesized through a feasible, three step reaction protocol. The structures of these mols. were established using FT-IR, 1H NMR, 13C NMR and HRMS techniques. In vitro susceptibility tests against some Gram pos. (Staphylococcus aureus and Bacillus subtilis) and Gram neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) exhibited broad spectrum potency of the mols. The most potent mol. (S2A7) amongst the screened mols., showed min. inhibitory concentration (MIC) value not less than 2.0μg/mL which was at par with the reference drug Streptomycin. Structure activity relationships revealed nitro and chloro groups being crucial for bioactivity when present at meta position of arylidene ring in 3-(3-(imidazol-1-yl)propyl)-5-(benzylidene)-2- (phenylimino)thiazolidin-4-one. DNA (DNA)and bovine serum albumin (BSA) binding studies for S2A7 under simulated physiol. pH were probed using UV Visible, fluorescence quenching, gel electrophoresis and mol. docking techniques. These studies established that S2A7 has strong binding affinity towards DNA and binds at the minor groove of DNA with binding constant (Kb) of 0.1287×102 L/mol. Mol. docking simulations of S2A7 with DNA and BSA predicted binding affinity of -9.2 and -7.2 kcal/mol, resp. Van der Waals forces and hydrogen bonding interactions were predicted as the main forces of interaction. With DNA, S2A7 exhibited specific binding affinity towards adenine-thiamine base pairs. The compound S2A7 forms a stable complex with BSA by binding at subdomain IIIA implying high bio-distribution of the compound The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole
The Article related to imidazole thiazolidinone antibiotic dna minor groove binder bacterial infection, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem