On June 30, 1985, Barbin, Alain; Laib, Reinhold J.; Bartsch, Helmut published an article.COA of Formula: C6H5N3O The title of the article was Lack of miscoding properties of 7-(2-oxoethyl)guanine, the major vinyl chloride-DNA adduct. And the article contained the following:
Chloroethylene oxide [7763-77-1], an ultimate carcinogenic metabolite of vinyl chloride, was reacted with poly(deoxyguanylate-deoxycytidylate) [36786-90-0]; the nucleic acid base adducts, 7-(2-oxoethyl)guanine [73100-87-5] and 3,N4-ethenocytosine [55662-66-3], were analyzed by reversed-phase HPLC. Chloroethylene oxide-modified poly(deoxyguanylate-deoxycytidylate) was assayed as template in a replication fidelity assay with Escherichia coli DNA polymerase I [9012-90-2], and the newly synthesized product was subjected to nearest-neighbor anal. Misincorporation rates of dAMP [653-63-4] and TMP [365-07-1] were increased with the level of template modification. About 80% of the mispairing events were located opposite minor cytosine lesions. 7-(2-Oxoethyl)guanine, the major adduct identified (>98% of the adducts), did not miscode for either thymine or adenine, failing to support an earlier hypothesis that the cyclic hemiacetal form, O6,7-(1′-hydroxyethano)guanine, could, by anal. with O6-methyl- and O6-ethylguanine, simulate adenine. Thus, direct miscoding of 7-(2-oxoethyl)guanine may contribute only slightly to the induction of mutations by chloroethylene oxide. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).COA of Formula: C6H5N3O
The Article related to oxyethylguanine chloroethylene oxide dna coding, ethenocytosine nucleic acid coding chloroethylene oxide, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.COA of Formula: C6H5N3O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem