On February 3, 2009, Knutson, Charles G.; Rubinson, Emily H.; Akingbade, Dapo; Anderson, Carolyn S.; Stec, Donald F.; Petrova, Katya V.; Kozekov, Ivan D.; Guengerich, F. Peter; Rizzo, Carmelo J.; Marnett, Lawrence J. published an article.COA of Formula: C6H5N3O The title of the article was Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts. And the article contained the following:
Non-invasive strategies for the anal. of endogenous DNA damage are of interest for the purpose of monitoring genomic exposure to biol. produced chems. The authors have focused the authors’ research on the biol. processing of DNA adducts and how this may impact the observed products in biol. matrixes. Preliminary research has revealed that pyrimidopurinone DNA adducts are subject to enzymic oxidation in vitro and in vivo and that base adducts are better substrates for oxidation than the corresponding 2′-deoxynucleosides. The authors tested the possibility that structurally similar exocyclic base adducts may be good candidates for enzymic oxidation in vitro. The authors investigated the in vitro oxidation of several endogenously occurring etheno adducts [1,N2-ε-guanine (1,N2-ε-Gua), N2,3-ε-Gua, heptanone-1,N2-ε-Gua, 1,N6-ε-adenine (1,N6-ε-Ade), and 3,N4-ε-cytosine (3,N4-ε-Cyt)] and their corresponding 2′-deoxynucleosides. Both 1,N2-ε-Gua and heptanone-1,N2-ε-Gua were substrates for enzymic oxidation in rat liver cytosol; heteronuclear NMR experiments revealed that oxidation occurred on the imidazole ring of each substrate. In contrast, the partially or fully saturated pyrimidopurinone analogs [i.e., 5,6-dihydro-M1G and 1,N2-propanoguanine (PGua)] and their 2′-deoxynucleoside derivatives were not oxidized. The 2′-deoxynucleoside adducts, 1,N2-ε-dG and 1,N6-ε-dA, underwent glycolytic cleavage in rat liver cytosol. Together, these data suggest that multiple exocyclic adducts undergo oxidation and glycolytic cleavage in vitro in rat liver cytosol, in some instances in succession. These multiple pathways of biotransformation produce an array of products. Thus, the biotransformation of exocyclic adducts may lead to an addnl. class of biomarkers suitable for use in animal and human studies. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).COA of Formula: C6H5N3O
The Article related to etheno propano dna base adduct oxidation glycolytic cleavage, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.COA of Formula: C6H5N3O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem