On February 28, 2007, Chen, Hauh-Jyun Candy; Kao, Chi-Fu published an article.Product Details of 55662-66-3 The title of the article was Effect of gender and cigarette smoking on urinary excretion of etheno DNA adducts in humans measured by isotope dilution gas chromatography/mass spectrometry. And the article contained the following:
Endogenous formation of the promutagenic DNA adducts 1,N6-ethenoadenine (εAde) and 3,N4-ethenocytosine (εCyt) has been considered as biomarkers originated from lipid peroxidation Elevated levels of εAde and εCyt were observed in cancer-prone tissues, suggesting the validity of these adducts in cancer risk assessment. The presence of DNA base adducts in biol. fluids is considered to derive primarily from base excision repair (BER) systems. In this study, a modified gas chromatog./mass spectrometry (GC/MS) method is developed for simultaneous anal. of εAde and εCyt in human urine. After adjusting for creatinine concentration, urinary excretion of εAde, as well as εCyt, is much higher in 18 male smokers than in 10 male nonsmokers (p = 0.003 for εAde and p = 0.04 for εCyt). Furthermore, excretion of εAde and εCyt in 14 female nonsmokers is much higher than in 10 male nonsmokers (p = 0.002 for εAde and p = 0.005 for εCyt). These results suggest a statistically significant association between gender, as well as smoking, and excretion of εAde and εCyt. Moreover, urinary excretion of εAde in these 42 subjects correlates with that of εCyt (R2 = 0.6846, p < 0.0001). Measurement of urinary εAde and εCyt excretion should provide valid noninvasive biomarkers for carcinogenesis and chemoprevention studies. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Product Details of 55662-66-3
The Article related to gender cigarette smoking urine etheno dna adduct, Toxicology: Methods (Including Analysis) and other aspects.Product Details of 55662-66-3
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