Wu, Feng published the artcileElectrophilic Fluorination of Imidazoheterocycles by Selectfluor, Safety of Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, the main research area is fluoro imidazoheterocycle preparation; imidazoheterocycle preparation electrophilic fluorination; ethyl bromopyruvate pyridinamine cyclization.
Response surface anal. (RSA) has been used for optimization of the synthesis using selectfluor as a fluorine source and Et imidazo[1,2-a]pyridine-2-carboxylate as a substrate. The latter has been synthesized by cyclization of Me 2-aminopyridine-3-formate with Et bromopyruvate. The optimal reaction conditions have been determined to be as follows: time 3 h, temperature 30°C and selectfluor rate 2.3 equivalent The triplicated verification experiments have led to the average yield of 87%. Four other fluorides of imidazoheterocycles I (R = H, Br; R1 = H, CHO, C(O)OMe; R2 = H, Me, Cl, F; R3 = H, ethoxycarbonyl; X = N, CH) have been synthesized under the optimized conditions.
Russian Journal of General Chemistry published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 67625-38-1 belongs to class imidazoles-derivatives, name is Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, and the molecular formula is C10H9ClN2O2, Safety of Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem