Vidal, Laura published the artcileBiotinylated Phosphorus Dendrimers as Control Line in Nucleic Acid Lateral Flow Tests, Computed Properties of 359860-27-8, the publication is Biomacromolecules (2020), 21(3), 1315-1323, database is CAplus and MEDLINE.
Lateral flow assays (LFA) are an affordable, easy-to-use, qual. rapid test for clin. diagnosis in nonlab. environments and low-resource facilities. The control line of these tests is very important to provide a valid result, confirming that the platform operates correctly. A clear, nondiffused line is desirable. The number of colored nanoparticles that reach the control line in a pos. test can be very small, and they should all be trapped efficiently by the mols. adsorbed there. In this work, we proposed the use of robust biotinylated dendrimers of two different generations as signal amplifiers in control lines of LFA, able to react with streptavidin-modified gold nanoparticles. Besides the synthesis and characterization, the anal. performance as control lines will be studied, and their response will be compared with other com. available biotinylated mols. Finally, the utility of the dendrimer implemented in a NALF (Nucleic Acid Lateral Flow) strip was also demonstrated for detection of the amplicons obtained by double-tagging PCR (polymerase chain reaction) for the detection of E. coli as a model of foodborne pathogen.
Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C4H7BrO2, Computed Properties of 359860-27-8.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem