Buehlmayer, Peter published the artcileNonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives, Product Details of C8H13ClN2O, the publication is Journal of Medicinal Chemistry (1991), 34(10), 3105-14, database is CAplus and MEDLINE.
(Tetrazolylnaphthalenylmethyl)imidazoles I (R = Cl, R1 = CH2OH, R2 = 1,2-Q, imidazole ring position = 5, 6, 7; R = CH2OH, R1 = Cl, R2 = 2-Q, imidazole ring position = 6) and (naphthalenylmethyl)imidazoles II (R = Cl, R1 = CH2OH, R3 = CO2H, 2-tetrazolyl, R4 = H, Me; R = CH2OH, R1 = Cl, R3 = CO2H, 2-tetrazolyl, R4 = H, Me) were prepared and examined as angiotensin II receptor antagonists and as inhibitors of angiotensin II induced contraction of rabbit aortic rings. Thus, 5-methylnaphthalen-1-ylcarbonitrile was brominated to the 5-(bromomethyl) derivative which reacted with 2-butyl-4(5)-chloro-5(4)-(hydroxymethyl)imidazole to give I (R = Cl, R1 = CH2OH, R2 = 1-cyano, imidazole ring position = 5) II. II was treated with Bu3SnN3 in xylene to give I (R = Cl, R1 = CH2OH, R2 = 2-Q, imidazole ring position = 6; R = CH2OH, R1 = Cl, R2 = 2-Q, imidazole ring position = 6) were the most potent of the compounds tested.
Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Product Details of C8H13ClN2O.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem