Gonzalez Cabrera, Diego published the artcileStructure-Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines, Name: Imidazo[1,2-a]pyridine-6-boronic acid, the publication is Journal of Medicinal Chemistry (2012), 55(24), 11022-11030, database is CAplus and MEDLINE.
Diarylpyridinamines such as I were prepared as antimalarial agents with reduced inhibition of the hERG potassium channel. The metabolic stabilities, lipophilicities, and aqueous solubilities of the diarylpyridinamines were determined; plasma concentrations in mice after oral dosage and hERG inhibition were determined for selected analogs. The structure-activity relations for in vitro antiplasmodial and hERG activities by diarylpyridinamines were delineated. Some of the diarylpyridinamines such as I exhibited potent antiplasmodial activity against both multidrug resistant and sensitive Plasmodium falciparum strains (for example, I showed Ki values of 12 nM and 15 nM against resistant and sensitive strains, resp.) and exhibited reduced inhibition of hERG channels (hERG inhibition observed for I at 20.2 μM). Mean survival time for mice given selected diarylpyridinamines orally in a Plasmodium berghei model of malaria was increased and parasitemia was reduced, but cures were not seen with the analogs as they were for the original lead compound series. Several diarylpyridinamines demonstrated promising in vivo efficacy in the Plasmodium berghei mouse model and will be further evaluated as potential clin. candidates.
Journal of Medicinal Chemistry published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, Name: Imidazo[1,2-a]pyridine-6-boronic acid.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem