Gumus, Fatma published the artcileSynthesis, Cytotoxicity, and DNA Interactions of New Cisplatin Analogues Containing Substituted Benzimidazole Ligands, Computed Properties of 4760-35-4, the publication is Journal of Medicinal Chemistry (2009), 52(5), 1345-1357, database is CAplus and MEDLINE.
Six new platinum(II) complexes (I; R = CH2Cl, CH2OCOMe, CH2CH2OH; R1 = H, Me) were synthesized and evaluated for their reactivity against model nucleophile I–, cellular uptake, and in vitro antiproliferative activities against the human MCF-7 breast and HeLa cervix cancer cell lines. The effect of the compounds on pBR322 plasmid DNA was studied by gel electrophoretic mobility measurements. Flow cytometric anal. was also carried out to study the effect of representative compounds bearing 2-chloromethyl or acetoxymethylbenzimidazole substituents on the cell cycle distribution of MCF-7 and HeLa cells, resp. In general, it was found that Pt(II) complexes were less cytotoxic than cisplatin and were comparable to carboplatin. The results of the plasmid DNA interaction and the restriction studies suggest that changing the chem. structure of the benzimidazole ligands may modulate DNA binding mode and the sequence selectivity. The studied compounds had no significant effect on the cell cycle profile of the cells used. However, the acetoxymethylbenzimidazole derivative induced a significant increase in the SubG1 cell population at a concentration of 20 μM.
Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem