Reference of 17325-26-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 121 -(4-Cyano-2-fluoro-rhenyl)-1 H-imidazole-4-carboxylic acid methyl ester: A mixture of 3,4-difluorobenzonitrile (193 mg), 1 H-imidazole-4-carboxylic acid methylester (160 mg), and potassium carbonate (150 mg) in N-methyl-2-pyrrolidinone (4mL) is heated to 15000 for 30 mm in a microwave oven. After cooling to room temperature, the reaction mixture is diluted with water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined extracts are dried over MgSO4 and concentrated in vacuo. The residue is triturated with t-butyl methylether, filtered off, and dried to give the title compound. LC (method 4): tR = 0.78 mm; Mass spectrum (ESI): mlz = 246 [M+H]
The synthetic route of Methyl 1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; NOSSE, Bernd; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; ASHWEEK, Neil J.; HARRIOTT, Nicole; WO2014/19967; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem