POD24 in follicular lymphoma: time to be “wise” was written by Leonard, John P.. And the article was included in Blood in 2022.Application of 16506-27-7 The following contents are mentioned in the article:
A polemic in response to Casulo et al is given. The present article describes about focusing on an important problem in follicular lymphoma. FL is the most common form of indolent non-Hodgkin lymphoma and the second most common type overall. After decades of minimal progress with chemotherapy-based treatments, availability of the anti-CD20 antibody rituximab (R) in 1997 led to significant improvements in overall survival. Initial management strategies for patients with advanced-stage disease now include observation for patients with asymptomatic, low tumor burden disease, whereas those requiring therapy may receive rituximab alone. Most patients receive rituximab (or the anti-CD20 obinutuzumab) in combination with chemotherapy such as bendamustine, cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP), or cyclophosphamide/vincristine/prednisone, which are sometimes followed by anti-CD20 antibody maintenance. Patients typically respond well to initial therapy, but relapse is expected within several years. Prognostic tools have been developed to predict outcomes, including the clin. Follicular Lymphoma International Prognostic Index (FLIPI)3 and a clinicogenetic risk model (m7-FLIPI). However, they are of limited value in choice of treatment, which is primarily driven by physician judgment and patient preferences rather than data demonstrating that one regimen is better than another for specific situations. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application of 16506-27-7).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 16506-27-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem