Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma was written by Takakuwa, Teruhito;Okayama, Yusuke;Nakamae, Hirohisa;Kuno, Masatomo;Makuuchi, Yosuke;Harada, Naonori;Okamura, Hiroshi;Nishimoto, Mitsutaka;Nakashima, Yasuhiro;Koh, Hideo;Hino, Masayuki. And the article was included in Annals of Hematology in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:
A case of ASCT performed following Pola-BR therapy for relapsed diffuse large B-cell lymphoma was reported. A 32-yr-old previously healthy man presented to hospital complaining of gradually worsening back pain that had first developed 3 mo earlier. Computed tomog. revealed multiple masses in the left liver lobe, pancreatic body, and both kidneys, as well as multiple enlarged lymph nodes. Based on the above findings, DLBCL stage IV was diagnosed. After six courses of R-CHOP, complete response (CR) was achieved, but back pain reoccurred 1 mo following treatment conclusion. Since a partial response was achieved after the first course of Pola-BR treatment, stem cell collection (SCC) at the conclusion of the second course was planned. MEAM (ranimustine, etoposide, cytarabine, and melphalan) with ASCT was subsequently performed and CR was achieved. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem