Synthetic Route of 17334-08-6, A common heterocyclic compound, 17334-08-6, name is (1-Methyl-1H-imidazol-2-yl)methanol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
This compound was synthesised using a modified procedure described in literature.6 1-Methyl-2-hydroxymethyl imidazole (6.500 g, 58.000 mmol) was added in small portions to SOCl2 (12.7 mL, 174 mol) at 0 C. The mixture was heated under reflux for 30 min. After cooling, the solution was concentrated under reduced pressure followed by recrystallization from ethanol (17 mL) to afford 2-(chloromethy1)-1-methyl-1H-imidazole hydrochloride. Yellow crystals; 7.580g, yield: 78%. The NMR spectrum was according to literature.6 1H NMR (CDCl3) delta = 7.79 (d, 1H, J = 1.9 Hz; ImH), 7.70 (d, 1H, J = 1.9 Hz; ImH), 5.20 (s, 2H; CH2Cl), 3.86 ppm (s, 3H; NCH3).
The synthetic route of 17334-08-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ionescu, Alexandra; Cornut, Damien; Soriano, Sebastien; Guissart, Celine; Van Antwerpen, Pierre; Jabin, Ivan; Tetrahedron Letters; vol. 54; 45; (2013); p. 6087 – 6089;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem