Taldone, Tony published the artcileDesign, synthesis, and evaluation of small molecule Hsp90 probes, Related Products of imidazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry (2011), 19(8), 2603-2614, database is CAplus and MEDLINE.
A number of compounds from different chem. classes are known to bind competitively to the ATP-pocket of Hsp90 and inhibit its chaperone function. The natural product geldanamycin was the first reported inhibitor of Hsp90 and since then synthetic inhibitors from purine, isoxazole and indazol-4-one chem. classes have been discovered and are currently or soon to be in clin. trials for the treatment of cancer. In spite of a similar binding mode to Hsp90, distinct biol. profiles were demonstrated among these mols., both in vitro and in vivo. To better understand the mol. basis for these dissimilarities, we report here the synthesis of chem. tools for three Hsp90 inhibitor classes. These agents will be useful for probing tumor-by-tumor the Hsp90 complexes isolated by specific inhibitors. Such information will lead to better understanding of tumor specific mol. markers to aid in their clin. development. It will also help to elucidate the mol. basis for the biol. differences observed among Hsp90 inhibitors.
Bioorganic & Medicinal Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C11H24O3, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem