Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors was written by Ma, Chunlong;Wang, Jun. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Electric Literature of C33H34N6O6 This article mentions the following:
Recently several study report the discovery of 16 Food and Drug Administration-approved drugs as severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) main protease (Mpro) inhibitors. They were identified from a computational virtual screening approach using the Mpro as the drug target, and their enzymic inhibition against SARS-CoV-2 M pro was validated in the fluorescence resonance energy transfer (FRET)-based enzymic assay (inhibitory constant Ki = 0.04 to 3.27μM). Here, authors highlight that among the discovered drugs dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C33H34N6O6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem