One-pot multicomponent synthesis of N-sulfonyl amidines using magnetic separable nanoparticles-decorated N-heterocyclic carbene complex with copper was written by Pawar, Arvind;Gajare, Shivanand;Patil, Audumbar;Kurane, Rajanikant;Rashinkar, Gajanan;Patil, Suresh. And the article was included in Research on Chemical Intermediates in 2021.Safety of 1-Methylbenzimidazole This article mentions the following:
Magnetic separable nanoparticles-decorated N-heterocyclic carbene complex with copper (MNP[1-Me benzimidazole]NHC@Cu) has been prepared by covalent grafting of ionic liquid like 1-Me benzimidazole unit on the surface of chlorofunctionalized Fe3O4 magnetic nanoparticles (MNPs) followed by metalation with copper(I) iodide. MNP[1-Me benzimidazole]NHC@Cu complex has been characterized by different techniques including Fourier transform IR spectroscopy, thermogravimetric anal., energy-dispersive X-ray anal., X-ray diffraction, transmission electron microscopy and vibrating sample magnetometer. MNP[1-Me benzimidazole]NHC@Cu complex was successfully implemented as heterogeneous catalyst in one-pot multicomponent synthesis of N-sulfonyl amidines from phenylacetylene, tosyl azide and amines at room temperature Complex could be recycled six times without significant loss in the yield of product. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Methylbenzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem