Formulation development and evaluaation of Candesartan Cilexetil immediate release tablets was written by Challa, Yellareddy;Banavath, Sujatha.;Swathi, Alle.;Eslavath, Ragya;Ramakrishna, Ubbani;Suthakaran, R.;Jyothirmai, Kalyankar Manasvi. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2018.Electric Literature of C33H34N6O6 This article mentions the following:
The tablets were prepared and evaluated using wet granulation technique. In order to optimize the product, different formulations were developed. And pre compression and post compression were evaluated. To check the compatibility of drug with various polymers,. FTIR spectra of Candesartan Cilexetil were recorded, The IR spectral anal. of Candesartan Cilexetil pure drug alone showed that principal peaks were observed at wave numbers 2939.13 cm-1, 1752.03 cm-1, 1546.56 cm-1, 1713.38 cm-1 and 1573.01 cm the major peaks were observed at 2937.48 cm-1, 1752.22 cm-1, 1546.30 cm-1, 1713.10 cm-1 and 1573.28 cm-1.. All the formulations were evaluated for phys. characteristics, Disintegration, in-vitro Dissolution and Stability studies. The Formulation F8 showed fair flow properties when compared to the reference product.From the obtained in vitro results of the above formulation Trials, We selected F – 8 as the optimized formulation because it showed total drug release with in 30 min than all other formulations and reference product. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem