Helal, Christopher J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 3034-41-1

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease was written by Helal, Christopher J.;Kang, Zhijun;Lucas, John C.;Gant, Thomas;Ahlijanian, Michael K.;Schachter, Joel B.;Richter, Karl E. G.;Cook, James M.;Menniti, Frank S.;Kelly, Kristin;Mente, Scot;Pandit, Jay;Hosea, Natalie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: imidazoles-derivatives This article mentions the following:

Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential metabolically mediated toxicity. The synthetic route utilized allowed for ready synthesis of 1-alkyl-4-(acylamino)imidazoles [alkyl = Me, i-Pr, cyclobutyl, 3-hydroxycyclobutyl, 3-(2-pyridylcarbonylamino)cyclobutyl, etc.; acyl = R2CO; R2 = PhCH2, 4-MeOC6H4CH2, 1-naphthylmethyl]. SAR exploration resulted in the identification of a novel cis-substituted cyclobutyl group that gave improved enzyme and cellular potency against cdk5/p25 with up to 30-fold selectivity over cdk2/cyclin E. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Category: imidazoles-derivatives).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem