4-Methyltrityl-Protected Pyrrole and Imidazole Building Blocks for Solid Phase Synthesis of DNA-Binding Polyamides was written by Heinrich, Benedikt;Vazquez, Olalla. And the article was included in Organic Letters in 2020.Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:
DNA-binding polyamides are synthetic oligomers of pyrrole/imidazole units with high specificity and affinity for double-stranded DNA. To increase their synthetic diversity, we report a mild methodol. based on 4-methyltrityl (Mtt) solid phase peptide synthesis (SPPS), whose building blocks are more accessible than the standard Fmoc and Boc SPPS ones. We demonstrate the robustness of the approach by preparing and studying a hairpin with all precursors. Importantly, our strategy is orthogonal and compatible with sensitive mols. and could be readily automated. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).
Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem