Heterocyclic analogs of pleiadiene. XXVIII. Reaction of 1,8-naphthalenediamine with aromatic and heteroaromatic aldehydes. Synthesis of 2-substituted derivatives of perimidine and 2-R-2,3-dihydroperimidines was written by Pozharskii, A. F.;Starshikov, N. M.;Pozharskii, F. T.;Mandrykin, Yu. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
Perimidines I (R = furyl, substituted furyl, pyrrolyl, thienyl, quinolyl, substituted phenyl, etc.) (20 compounds) were prepared in 60-96% yields by cyclizing II with RCHO. Dehydrogenation of I with Pd/C in xylene, nitrobenzene, etc. gave 30-90% III. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem