The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma was written by Inoue, Chisa;Yasuma, Taro;D’Alessandro-Gabazza, Corina N.;Toda, Masaaki;Fridman D’Alessandro, Valeria;Inoue, Ryo;Fujimoto, Hajime;Kobori, Hajime;Tharavecharak, Suphachai;Takeshita, Atsuro;Nishihama, Kota;Okano, Yuko;Wu, Jing;Kobayashi, Tetsu;Yano, Yutaka;Kawagishi, Hirokazu;Gabazza, Esteban C.. And the article was included in Cells in 2022.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:
The leading cause of death worldwide is cancer. Many reports have proved the beneficial effect of mushrooms in cancer. However, the precise mechanism is not completely clear. In the present study, we focused on the medicinal properties of biomols. released by fairy ring-forming mushrooms. Fairy chems. generally stimulate or inhibit the growth of surrounding vegetation. In the present study, we evaluated whether fairy chems. (2-azahypoxanthine, 2-aza-8-oxohypoxanthine, and imidazole-4-carboxamide) exert anticancer activity by decreasing the expression of Axl and immune checkpoint mols. in melanoma cells. We used B16F10 melanoma cell lines and a melanoma xenograft model in the experiments Treatment of melanoma xenograft with cisplatin combined with imidazole-4-carboxamide significantly decreased the tumor volume compared to untreated mice or mice treated cisplatin alone. In addition, mice treated with cisplatin and imidazole-4-carboxamide showed increased peritumoral infiltration of T cells compared to mice treated with cisplatin alone. In vitro studies showed that all fairy chems., including imidazole-4-carboxamide, inhibit the expression of immune checkpoint mols. and Axl compared to controls. Imidazole-4-carboxamide also significantly blocks the cisplatin-induced upregulation of PD-L1. These observations point to the fairy chem. imidazole-4-carboxamide as a promising coadjuvant therapy with cisplatin in patients with cancer. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1H-Imidazole-4-carboxamide
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem