Preformulation study for candesartan cilexetil buccal (Effervescent) tablet was written by Pansuriya, K.;Parejiya, P.;Suthar, D.;Shelat, P.;Vekariya, A.;Patel, H.. And the article was included in Pharma Innovation in 2019.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:
Candesartan cilexetil is novel, potent and highly selective non peptide angiotensin II type 1 receptor blocker. It is hydrophobic drug which belongs to BCS Class II drug. For enhancement the bioavability and quick systemic action of candesartan cilexetil a novel formulation of buccal (effervescent) tablet was designed. Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: Bulk d. (du), Tapped d. (db), Compressibility Index (%C) and sieve anal. was performed in order to determine the best excipients to be used in the formulation development of Candesartan cilexetil (effervescent) tablets. Results show that Candesartan Cilexetil has fair flow and compressibility properties du 0.8 g/mL, db 0.7 g/mL, %C 12.5 and sieve anal. time 4.5 min. HPLC method for estimation of Candesartan cilexetil shows linearity (R2 = 1) and specific with no interference of excipients. Solubility studies reveals that it soluble at pH 6.8 and 7.5 in phosphate buffer. The ability of material to absorb water (Hygroscopicity) was found 0.1% after 24 Hrs at 80% Relative Humidity. M.p. rage from 161-165°C. There was no any drug excipients interaction was observed when analyzed through FTIR and DSC. There was no change in appearance after 15 days at 40°C and 75% Relative humidity. These all results lead to the better development of Candesartan cilexetil buccal (effervescent) tablet. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem