Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group was written by Tang, Xiao-Jun;Wu, Yayun;Zhao, Rong;Kou, Xiaolong;Dong, Zaizai;Zhou, Wei;Zhang, Zhen;Tan, Weihong;Fang, Xiaohong. And the article was included in Angewandte Chemie, International Edition in 2020.Product Details of 25676-75-9 This article mentions the following:
The photorelease of bioactive mols. has emerged as a valuable tool in biochem. Nevertheless, many important bioactive mols., such as pyridine derivatives, cannot benefit from currently available organic photoremovable protecting groups (PPGs). The inefficient photorelease of pyridines is attributed to intramol. photoinduced electron transfer (PET) from PPGs to pyridinium ions. To alleviate PET, the authors rationally designed a strategy to drive the excited state of PPG from S1 to T1 with a heavy atom, and synthesized a new PPG by substitution of the H atom at the 3-position of 7-dietheylamino-coumarin-4-Me (DEACM) with Br or I. This resulted in an improved photolytic efficiency of the pyridinium ion by hundreds-fold in aqueous solution The PPG can be applied to various pyridine derivatives The successful photorelease of a microtubule inhibitor, indibulin, in living cells was demonstrated for the potential application of this strategy in biochem. research. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Product Details of 25676-75-9).
4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 25676-75-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem