KOtBu-Catalyzed 1,2-Silaboration of N-Heteroarenes to Access 2-Silylheterocycles: A Cooperative Model for the Regioselectivity was written by Jeong, Eunchan;Heo, Joon;Jin, Seongho;Kim, Dongwook;Chang, Sukbok. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 1632-83-3 This article mentions the following:
Reductive functionalization of N-heteroarenes offers a route to highly versatile heterocyclic synthons bearing multiple transformable groups. The authors present herein the development of KOtBu-catalyzed 1,2-silaboration of a broad range of N-heteroarenes, affording heterocyclic allylamines or enamines with the formation of a sp3 C2-Si bond. These labile compounds were isolated either as their N-acyl derivatives or as rearomatized 2-silyl-N-heteroarenes by the 1-pot procedures. A model of the six-membered ion-pair complex is proposed to rationalize the observed 1,2-regioselectivity, wherein KOtBu catalyst plays an associative role in activating the substrate and silylborane reagent. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 1632-83-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem