Synthesis of Well-Defined Adenosine Diphosphate Ribose Oligomers was written by Kistemaker, Hans A. V.;Lameijer, Lucien N.;Meeuwenoord, Nico J.;Overkleeft, Herman S.;van der Marel, Gijsbert A.;Filippov, Dmitri V.. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:
The post-translational modification of proteins that is known as ADP ribosylation (ADPr) regulates a wide variety of important biol. processes, such as DNA-damage repair and cellular metabolism This modification is also involved in carcinogenesis and the process of aging. Therefore, a better understanding of the function of ADP-ribosylation is crucial for the development of novel therapeutics. To facilitate the elucidation of the biol. of ADPr, the availability of well-defined fragments of poly(ADP-ribose) is essential. Herein we report a solid-phase synthetic approach for the preparation of ADP-ribose oligomers of exactly defined length. The methodol. is exemplified by the first reported synthesis of an ADP-ribose dimer and trimer. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).
1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem