Carbon-13, nitrogen-14, nitrogen-15, and oxygen-17 NMR spectra of nitropyrroles and nitroimidazoles was written by Lippmaa, E.;Magi, M.;Novikov, S. S.;Khmelnitski, L. I.;Prihodko, A. S.;Lebedev, O. V.;Epishina, L. V.. And the article was included in Organic Magnetic Resonance in 1972.Recommanded Product: 3034-41-1 This article mentions the following:
C, N, and O NMR spectra of nitro derivatives of pyrrole and imidazole are investigated. The 13C chem. shifts of para-C atoms and the 17O chem. shifts of the nitro group correlate qual. with the electron ds. on these C and O atoms, which in turn depend upon the degree of conjugation of the nitro groups with the heterocyclic ring. Conjugation of several nitro groups with the benzene ring is not impaired by mutual interactions and the 13C shifts are additive. Additivity is much worse in pyrrole and imidazole derivatives Taken together with the diamagnetic nature of these deviations from additivity, this leads to a possible conclusion about the less pronounced conjugation of the nitro groups with the heterocyclic ring in heterocyclic dinitro derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem