Author: Jessica.F

Structure-Guided Screening for Functionally Selective D₂ Dopamine Receptor Ligands from a Virtual Chemical Library was written by Maennel, Barbara;Jaiteh, Mariama;Zeifman, Alexey;Randakova, Alena;Moeller, Dorothee;Huebner, Harald;Gmeiner, Peter;Carlsson, Jens. And the article was included in ACS Chemical Biology in 2017.COA of Formula: C4H9Cl2N3 This article mentions the following:

Functionally selective ligands stabilize conformations of G protein-coupled receptors (GPCRs) that induce a preference for signaling via a subset of the intracellular pathways activated by the endogenous agonists. The possibility to fine-tune the functional activity of a receptor provides opportunities to develop drugs that selectively signal via pathways associated with a therapeutic effect and avoid those causing side effects. Animal studies have indicated that ligands displaying functional selectivity at the D₂ dopamine receptor (D₂R) could be safer and more efficacious drugs against neuropsychiatric diseases. In this work, computational design of functionally selective D₂R ligands was explored using structure-based virtual screening. Mol. docking of known functionally selective ligands to a D₂R homol. model indicated that such compounds were anchored by interactions with the orthosteric site and extended into a common secondary pocket. A tailored virtual library with close to 13 000 compounds bearing 2,3-dichlorophenylpiperazine, a privileged orthosteric scaffold, connected to diverse chem. moieties via a linker was docked to the D₂R model. Eighteen top-ranked compounds that occupied both the orthosteric and allosteric site were synthesized, leading to the discovery of 16 partial agonists. A majority of the ligands had comparable maximum effects in the G protein and 尾-arrestin recruitment assays, but a subset displayed preference for a single pathway. In particular, compound I stimulated 尾-arrestin recruitment (EC₅₀ = 320 nM, E_max = 16%) but had no detectable G protein signaling. The use of structure-based screening and virtual libraries to discover GPCR ligands with tailored functional properties will be discussed. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7COA of Formula: C4H9Cl2N3).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C4H9Cl2N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds was written by Moon, Malcolm W.;Morris, Jeanette K.;Heier, Richard F.;Chidester, Connie G.;Hoffmann, William E.;Piercey, Montford F.;Althaus, John S.;VonVoigtlander, Philip F.;Evans, Dawna L.. And the article was included in Journal of Medicinal Chemistry in 1992.Name: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (I), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT_1A) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of I; the (S)-enantiomer shows no dopaminergic activity. A series of analogs where the imidazolone ring was modified to various 5- or 6-membered heterocyclic rings were prepared Some of these compounds showed a combination of dopaminergic and serotonergic activity, while one compound, 6-(dipropylamino)-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-one (II), was a selective serotonergic agonist. Various analogs of I where the dipropylamine substituent was modified were prepared Most of these showed reduced dopaminergic activity, while several were as potent as I at the serotonin 5HT_1A receptor. Orientations for the new compounds at dopamine and serotonin receptors are proposed and compared with those of other tricyclic ligands known to have high affinity at these receptors. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Name: 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

NAE modulators: A potential therapy for gastric carcinoma was written by Liang, Qi;Liu, Maoyu;Li, Jian;Tong, Rongsheng;Hu, Yonghe;Bai, Lan;Shi, Jianyou. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 145040-37-5 This article mentions the following:

Neural precursor cell expressed developmentally downregulated protein-8 (NEDD8) is a ubiquitin-like protein, which activates an important post-translational modification process: neddylation, thereby regulating the stability and degradation of various proteins related to multiple physiol. processes. And the abnormal activation of NEDD8 (overexpression or underexpression) is related to the occurrence of multiple cancers including gastric carcinoma. NEDD8 activating enzyme (NAE), a key enzyme for the activation of NEDD8, controls the initiation of the NEDD8 transfer cascade, which is an important target for anti-tumor drugs. With the disclosure of the anti-tumor mechanism, NAE modulators (inhibitors and agonists) have gradually become a research hotspot in the development of anti-tumor drugs. And the application of NAE modulators has also been further expanded, not only limited to certain hematol. tumors, its therapeutic potential in multiple solid tumors, especially gastric carcinoma, has been gradually uncovered. This paper mainly explains the structural characteristics, catalytic sites, and mechanism of NAE. And the relationships between neddylation and tumors are also elaborated from the perspective of NAE regulating the downstream pathways. In addition, the NAE modulators reported in recent years were reviewed, mainly focusing on their discovery processes, structure-activity relationships, inhibitory efficacy, pharmacol. mechanism, and clin. research. And we reasonably predict the application of NAE modulators in gastric carcinoma, according to its relationship with neddylation. We summarize the issues in NAE modulator development and discuss the possible development directions. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The association between cardiac drug therapy and anxiety among cardiac patients: results from the national DenHeart survey was written by Rotvig, Camilla;Christensen, Anne Vinggaard;Juel, Knud;Svendsen, Jesper Hastrup;Joergensen, Martin Balslev;Rasmussen, Trine Bernholdt;Borregaard, Britt;Thrysoee, Lars;Thorup, Charlotte Brun;Mols, Rikke Elmose;Berg, Selina Kikkenborg. And the article was included in BMC Cardiovascular Disorders in 2022.Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Neuropsychiatric side effects of cardiac drugs such as nervousness, mood swings and agitation may be misinterpreted as symptoms of anxiety. Anxiety in cardiac patients is highly prevalent and associated with poor outcomes, thus an accurate identification is essential. The objectives were to: (I) describe the possible neuropsychiatric side effects of common cardiac drug therapies, (II) describe the use of cardiac drug therapy in cardiac patients with self-reported symptoms of anxiety compared to those with no symptoms of anxiety, and (III) investigate the association between the use of cardiac drug therapy and self-reported symptoms of anxiety. DenHeart is a large national cross-sectional survey combined with national register data. Symptoms of anxiety were measured by the Hospital Anxiety and Depression Scale (HADS-A) on patients with ischemic heart disease, arrhythmia, heart failure and heart valve disease. Side effects were obtained from product summaries, and data on redeemed prescriptions obtained from the Danish National Prescription Registry. Multivariate logistic regression analyses explored the association between cardiac drug therapies and symptoms of anxiety (HADS-A 鈮?8). Among 8998 respondents 2891 (32%) reported symptoms of anxiety (HADS-A 鈮?8). Neuropsychiatric side effects were reported from digoxin, antiarrhythmics, beta-blockers, ACE-inhibitors and angiotensin receptor antagonists. Statistically significant higher odds of reporting HADS 鈮?8 was found in users of diuretics, lipid-lowering agents, nitrates, antiarrhythmics and beta-blockers compared to patients with no prescription. Conclusion: Some cardiac drugs were associated with self-reported symptoms of anxiety among patients with cardiac disease. Of these drugs neuropsychiatric side effects were only reported for antiarrhythmics and beta-blockers. Increased awareness about the possible adverse effects from these drugs are important. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Facile access to N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones was written by Huang, Hsin-Yi;Lin, Xiu-Yi;Yen, Shih-Yao;Liang, Chien-Fu. And the article was included in Organic & Biomolecular Chemistry in 2020.Reference of 1632-83-3 This article mentions the following:

N-Formamides e.g., N-benzylformamide synthesis using N-formyl imide RC(O)NHC(O)H (R = Ph, tert-Bu, pyridin-4-yl, thiophen-2-yl, etc.) with primary and secondary amines e.g., benzylamine with catalytic amounts of p-toluenesulfonic acid monohydrate (TsOH路H₂O) is described. This reaction is performed in water without the use of surfactants. Moreover, N-formyl imide is efficiently synthesized using acylamidines RC(O)N=CHN(CH₃)₂ with TsOH路H₂O in water. In addition, N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole I (R¹ = H, Me; R² = H, Me, F, CN, etc.; R³ = H, Me, Cl; R⁴ = H, Me, Bn, Ts; R²R³ = -CH=CH-CH=CH-) and quinazolinone derivs II (R⁵ = H, Pr, Ph, cyclopentyl, etc.). Notable features of N-formylation of amines by using N-formyl imide include operational simplicity, oxidant- and metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase was written by Kaur, Supreet;Nieto, Nicholas S.;McDonald, Peter;Beck, Josh R.;Honzatko, Richard B.;Roy, Anuradha;Nelson, Scott W.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2022.Application of 145040-37-5 This article mentions the following:

Malaria is caused by infection with protozoan parasites of the Plasmodium genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast. The apicoplast genome is replicated by a single DNA polymerase (apPOL), which is an attractive target for anti-malarial drugs. We screened small-mol. libraries (206,504 compounds) using a fluorescence-based high-throughput DNA polymerase assay. Dose/response anal. and counter-screening identified 186 specific apPOL inhibitors. Toxicity screening against human HepaRG human cells removed 84 compounds and the remaining were subjected to parasite killing assays using chloroquine resistant P. falciparum parasites. Nine compounds were potent inhibitors of parasite growth and may serve as lead compounds in efforts to discover novel malaria drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and evaluation of 2-(4-[4-acetylpiperazine-1-carbonyl] phenyl)-1H-benzo[d]imidazole-4-carboxamide derivatives as potential PARP-1 inhibitors and preliminary study on structure-activity relationship was written by Chen, Miaojia;Huang, Honglin;Wu, Kaiyue;Liu, Yunfan;Jiang, Lizhi;Li, Yang;Tang, Guotao;Peng, Junmei;Cao, Xuan. And the article was included in Drug Development Research in 2022.Category: imidazoles-derivatives This article mentions the following:

A series of 2-(4-[4-substitutedpiperazine-1-carbonyl]phenyl)-1H-benzo[d]imidazole-4-carboxamide derivatives I [R = Me, Ph, 2-furyl, etc.] was designed, synthesized and successful characterization as novel and effective poly ADP-ribose polymerases (PARP)-1 inhibitors to improve the structure-activity relationships about the substituents in the hydrophobic pocket. These derivatives were evaluated for their PARP-1 inhibitory activity and cellular inhibitory against BRCA-1 deficient cells (MDA-MB-436) and wild cells (MCF-7) using PARP kit assay and MTT method. The results indicated that compared with other heterocyclic compounds, furan ring-substituted derivatives I [R = 2-furyl, 3-methyl-2-furyl, 5-bromo-2-furyl, 5-chloro-2-furyl] showed better PARP-1 inhibitory activity. Among this derivatives, compound I [R = 5-bromo-2-furyl] displayed the strongest inhibitory effects on PARP-1 enzyme (IC₅₀ = 0.023渭M), which was close to that of Olaparib. The compounds I [R = 5-bromo-2-furyl] (IC₅₀ = 43.56 卤 0.69渭M) and I [R = 5-chloro-2-furyl] (IC₅₀ = 36.69 卤 0.83渭M) displayed good antiproliferation activity on MDA-MB-436 cells and inactivity on MCF-7 cells, indicating that they had high selectivity and targeting. The mol. docking method was used to explore the binding mode of compound I [R = 5-bromo-2-furyl] and PARP-1, and implied that the formation of hydrogen bond was essential for PARP-1 inhibition activities. This study also showed that in the hydrophobic pocket (AD binding sites), the introduction of strong electroneg. groups (furan ring, e.g.) or halogen atoms in the side chain of benzimidazole might improve its inhibitory activity and this strategy could be applied in further research. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Category: imidazoles-derivatives).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Understanding effect of molecular structure of imidazole-based ionic liquids on catalytic performance for biomass inulin hydrolysis was written by Lu, Peng;Zhao, Zhi-Ping;Wang, Xing-Ya;Lan, Gong-Jia;Wang, Xiao-Lan. And the article was included in Molecular Catalysis in 2017.Reference of 35487-17-3 This article mentions the following:

Developing a green hydrolysis process of biomass for the production of the value-added compounds has been widely concerned. This article aimed at elucidating the structure-property relationship of ionic liquids (ILs) as catalysts, i.e., effect of the chem. structures of anion and cation of ILs on their acidity and catalytic properties of inulin hydrolysis. Twenty kinds of imidazole-based ILs and one kind of quaternary ammonium ILs were synthesized. Inulin hydrolysis for the reducing sugar production was investigated with a series of functionalized ILs under moderate temperature (75 掳C) and atm. pressure. The chem. structure, acidity and catalytic property of ILs were exptl. characterized and theor. analyzed. The possible catalytic hydrolysis mechanisms of polysaccharide or lignocellulose by ILs were detailedly analyzed. This work demonstrated that the catalytic performance of catalysts depends not only on its acidity, but also on the chem. structure. It was revealed that imidazole-based ILs showed better catalytic performance than quaternary ammonium ILs in the inulin hydrolysis system, and SO₃H-functionalized sulfonate ILs obtained more efficient catalytic property because the hydrolysis reaction was catalyzed by the synergy of anion and cation, compared with the sulfuric acid with stronger acidity, which can cause serious equipment corrosion in biomass hydrolysis process. In all these tested ILs, (1-(4-sulfonic acid)-butyl-3-ethylimidazolium hydrogen sulfate) ([C₂MIM-PS][HSO^–₄]) exhibited the best catalytic performance, and the yield of reducing sugar was 100%. Understanding the structure-property relationship of ILs will be helpful to design the covalent immobilization strategy of ILs to improve its reusability and eliminate the potential harmfulness to the environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Reference of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroimidazoles with a halogen-containing side-chain was written by Baird, Ian R.;Patrick, Brian O.;Skov, Kirsten A.;James, Brian R.. And the article was included in Canadian Journal of Chemistry in 2018.Formula: C5H5N3O4 This article mentions the following:

Syntheses are reported for: nine 2-nitroimidazoles, five 2-methyl-5-nitroimidazoles, and five 2-methyl-4-nitroimidazoles. The nitroimidazoles all have an amide side-chain at the N1 atom of the imidazole, with 17 of them containing one to five halogen atoms. The aim is to study compounds for comparison with EF5 (I), a previously reported, pentafluoropropylacetamide derivative of 2-nitroimidazole that is currently used as a hypoxia marker drug to detect cancerous tumors. The new compounds are characterized by standard methods, including X-ray structural data. Intra- and inter-mol. H-bonding is seen in the solid state structures, likely an important property in biol. use; another key property of the nitroimidazoles is their reduction potentials, and the measured CV data confirm that 2-nitroimidazole compounds with longer side-chains and more F-atoms (like I) are worth investigating for possible activity as hypoxia-selective, bioreductive agents. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Formula: C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lewis acid / base-free strategy for the synthesis of 2-arylthio and selenyl benzothiazole / thiazole and imidazole was written by Balakishan, Guniganti;Kumaraswamy, Gullapalli;Narayanarao, Vykunthapu;Shankaraiah, Pagilla. And the article was included in Heterocyclic Communications in 2021.Related Products of 1632-83-3 This article mentions the following:

A Cu(II)-catalyzed Csp²-Se and Csp²-sulfur bond formation was achieved with moderate to good yields without the aid of Lewis acid and base. The reaction was compatible with a wide range of heterocycles such as benzothiazole, thiazole and imidazole. Also, this typical protocol was found to be active in thio-selenation via S-H activation. Addnl., a plausible mechanistic pathway involving Cu(III) putative intermediate was proposed. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem