Author: Jessica.F

Unsaturated azole derivatives. II. Synthesis and reactions of some 尾-(azol-2-yl)propiolic acids was written by Simonov, A. M.;Popov, I. I.;Mikhailov, V. I.;Sil’vanovich, N. A.;Shelepin, O. E.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1974.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Benzimidazole-acrylates I (R = H, MeO, Me) were prepared in 鈭?0% yields by condensation of the appropriate benzimidazolecarboxaldehyde with Ph3P:CBrCO2Me. Dehydrobromination of I with KOH gave 鈭?0% yields of the corresponding propiolic acid derivatives II. Analogously obtained from the appropriate heterocyclic aldehyde were imidazolepropiolic acid III and 2-benzothiazolepropiolic acid (IV). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone As a Potent and Selective I_Kur Inhibitor was written by Finlay, Heather J.;Lloyd, John;Vaccaro, Wayne;Kover, Alexander;Yan, Lin;Bhave, Gauri;Prol, Joseph;Huynh, Tram;Bhandaru, Rao;Caringal, Yolanda;DiMarco, John;Gan, Jinping;Harper, Tim;Huang, Christine;Conder, Mary Lee;Sun, Huabin;Levesque, Paul;Blanar, Michael;Atwal, Karnail;Wexler, Ruth. And the article was included in Journal of Medicinal Chemistry in 2012.HPLC of Formula: 3012-80-4 This article mentions the following:

Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I_Kur current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent I_Kur inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone I, with an acceptable PK profile in preclin. species and potent efficacy in the preclin. rabbit atrial effective refractory period (AERP) model. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was written by Liu, Dandan;Ge, Huan;Xu, Fangling;Xu, Yufang;Liu, Wenjun;Li, Honglin;Zhu, Lili;Diao, Yanyan;Zhao, Zhenjiang. And the article was included in Chinese Chemical Letters in 2022.Recommanded Product: 25676-75-9 This article mentions the following:

The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms (MPNs). At present, there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic. In this paper, a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design, synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib. Among them, I exhibited high inhibitory activity against JAK2 with an IC₅₀ of 9 9 nmol/L, moreover, it showed 276- and 184-fold selectivity over JAK1 and JAK3, resp. Besides, I had a significant antiproliferative activity against HEL cells, and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway. These results indicated that 2-aminopyridine compound I had the potential to be developed as a selective JAK2 inhibitor for further study. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Recommanded Product: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Halogenated (acylamino)imidazoles and benzimidazoles for directed halogen-metal exchange-based functionalization was written by Groziak, Michael P.;Ding, Hong. And the article was included in Acta Chimica Slovenica in 2000.Electric Literature of C4H5N3O2 This article mentions the following:

Regioselective syntheses of 4- and 5-(acylamino)-1-alkylimidazoles bearing an ortho-halogen atom have been developed. Suitable for use in ortho-directed halogen-metal exchange-mediated ring functionalizations, these compounds are valuable precursors to ortho-functionalized versions of biol. active 4- and 5-aminoimidazoles. To widen the scope of this approach to cover similarly-substituted benzimidazoles and their potentially bioactive nucleosides, the synthesis of halogenated 5- and 6-(acylamino)-benzimidazoles and their ribosides was also explored. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Electric Literature of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vascular action of some imidazoles was written by Loeper, M.;Mougeot, A.;Aubertot, R.. And the article was included in Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales in 1934.SDS of cas: 26832-08-6 This article mentions the following:

The action of 4-methylimidazole, 4-methoxyimidazole, imidazole-4-formamide and diarabinotetrahydroxybutylimidazole on snail hearts, isolated arteries and live dogs was studied. The first 2 are hypertensive. Similar experiments by others with various imidazole derivatives are reviewed. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A simple group contribution correlation for the prediction of ionic liquid heat capacities at different temperatures was written by Ahmadi, Alireza;Haghbakhsh, Reza;Raeissi, Sona;Hemmati, Vahid. And the article was included in Fluid Phase Equilibria in 2015.Category: imidazoles-derivatives This article mentions the following:

The heat capacities of pure ionic liquids (ILs) are among the thermophys. properties that are required for certain engineering calculations and designs. In this study, a simple correlation is presented for the prediction of the heat capacities of pure ionic liquids This correlation is a temperature-dependent relation that uses temperature, mol. weight and the number of atoms (such as carbon, hydrogen, oxygen, nitrogen, etc.) in the structure of the IL as input parameters. A dataset of approx. 128 different ILs, consisting of 4822 data points, was used to develop and validate this general correlation, covering a temperature range from 190 to 663 K. Nearly three-quarters of the data were used for optimization and a quarter for validation. The resulting correlation gives good estimations for heat capacities, while having a number of advantages over previous literatures methods. These advantages include (a) being very simple; (b) not requiring any exptl. data as input parameters; (c) being more global than previous literature models by having been constructed over a larger databank of ionic liquids; (d) being accurate. The average absolute relative deviation (AARD%) was calculated to be 5.8% for the optimization dataset, and 5.6% for the validation dataset. This is smaller than what is obtained for the literature at.-contribution methods proposed by Farahani et al. and Sattari et al., with AARD% values of 14.2% and 6.6%, resp., based on the validation dataset of this study. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Category: imidazoles-derivatives).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ragi (finger millet) starch-based gel electrolytes for dye-sensitized solar cell application was written by Yogananda, K. C.;Ramasamy, Easwaramoorthi;Vasantha Kumar, S.;Rangappa, Dinesh. And the article was included in Bulletin of Materials Science in 2021.Application of 1632-83-3 This article mentions the following:

Starch was isolated from ragi grains using alkali extraction method. Crystallinity of isolated ragi starch (RGS) was studied using X-ray diffraction technique, and thermal properties of RGS were characterized by differential scanning calorimetry. Novel ragi starch (RGS) based gel electrolyte for dye-sensitized solar cells (DSSCs) was prepared and characterized for the first time. In the first part, the effects of additives guanidinium thiocyanate (GSCN) and N-methylbenzimidazole (NMBI) on the photovoltaic performance of DSSC were investigated. Considerable improvement of open circuit voltage was found in the addition of only NMBI to the electrolyte, while only addition of GSCN has an influence on the short circuit current. Synergetic effects were observed when NMBI and GSCN were used together in the gel electrolyte. In the second part, various weight percentages of multiwalled carbon nanotubes (MWCNTs) were added to observe the cell performance. DSSCs fabricated with the optimum weight percentage (1 wt%) of MWCNT achieved a maximum conversion efficiency of 4.34%, an open circuit voltage (V_oc) of 0.803 V, short circuit c.d. (J_sc) of 9.54 mA cm^-2 and fill factor (FF) of 56.59%. Here we reported the novel ragi starch-based gel electrolytes for DSSC application along with the effect of different additives, such as GSCN, NMBI, and various weight percentages of MWCNTs incorporated into the gel electrolyte. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

(Benz-)imidazolin-2-ylidene-benzimidazolatonickel(II) Chelates: Syntheses, Structures, and Tuning of Noninnocent Chelate Ligand Behavior was written by Kureja, Kunal;Bruhn, Clemens;Ringenberg, Mark R.;Siemeling, Ulrich. And the article was included in Inorganic Chemistry in 2019.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

The deprotonation of 1-(1H-benzimidazol-2-yl)-3-methylbenzimidazolium hexafluorophosphate (2^MeH₂[PF₆]) and 1-(1H-benzimidazol-2-yl)-3-isopropylbenzimidazolium hexafluorophosphate (2^iPrH₂[PF₆]) with potassium tert-butoxide in THF afforded the benzimidazolium-benzimidazolates 2^MeH and 2^iPrH. The “instant carbene” behavior of these conjugated mesomeric betaines was demonstrated by trapping their carbenic tautomers 2‘^MeH and 2‘^iPrH with elemental sulfur and selenium, which afforded the corresponding thio- and selenourea derivatives 2‘^MeHE and 2‘^iPrHE (E = S, Se). The treatment of 2^MeH and 2^iPrH with nickelocene furnished the nickel(II) complexes [NiCp(2‘^Me)] and [NiCp(2‘^iPr)], which contain an anionic C,N_amido-chelating NHC ligand. The electronic structure and redox behavior of the nickel(II) chelates were investigated, as well as those of the closely related chelates [NiCp(1‘^Me)] and [NiCp(1‘^iPr)] derived from the corresponding imidazolium-benzimidazolates 1^MeH and 1^iPrH. According to DFT calculations, the HOMO is located over the NiCp moiety and the 蟺 system of the chelate ligand with a large contribution from the (benz-)imidazolate moiety. Cyclic voltammetry revealed a reversible oxidation to the monocation [NiCp(L)]⁺ (E_1/2 = 0.315, 0.222, 0.396, 0.265 V vs. ferrocene/ferrocenium for L = 1‘^Me, 1‘^iPr, 2‘^Me, 2‘^iPr, resp.) in CH₂Cl₂/0.1 M n-Bu₄N[B(Ar^F)₄] (B(Ar^F)₄^– = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), and isosbestic behavior was found in UV-vis-NIR spectroelectrochem. experiments The different redox potentials reflect the different donor/acceptor properties of the NHC part of the chelate ligands, with 1′^iPr being the strongest and 2‘^Me the weakest net electron donor. The EPR spectroscopic signature of [NiCp(2′^Me)]⁺ in CH₂Cl₂/0.1 M n-Bu₄N[B(Ar^F)₄] at 100 K is consistent with a chelate-ligand-based radical with strong spin-orbit coupling to the Ni center. In contrast, the EPR spectra of [NiCp(1‘^Me)]⁺, [NiCp(1‘^iPr)]⁺, and [NiCp(2‘^iPr)]⁺ indicate that these monocations are best described as Ni^III complexes, the comparatively higher contribution of the Ni^III(L) vs. the Ni^II(L^鈥?) valence tautomer being supported by the results of open-shell DFT calculations C,N_amido-nickel(II) chelates [NiCp(L)] containing (benz-)imidazolin-2-ylidene-benzimidazolate ligands (L) are reversibly oxidized to [NiCp(L)]⁺. The [NiCp(L)] HOMO and [NiCp(L)]⁺ SOMO are delocalized over the NiCp unit and the (benz-)imidazolate moiety of L. The chelate ligand L can support the unusual oxidation state Ni^III. Its noninnocent behavior may be tuned by the N substituent and the backbone of its NHC part, the carbene’s substitution pattern thus determining the relative contribution of the Ni^III(L) vs. the Ni^II(L^鈥?) valence tautomer of [NiCp(L)]⁺. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Selection of low-toxic and highly efficient ionic liquids for the separation of palladium and platinum in acidic solution, and prediction of the metal affinity of ionic liquids was written by Lim, Che-Ryong;Choi, Jong-Won;Yun, Yeoung-Sang;Cho, Chul-Woong. And the article was included in Separation and Purification Technology in 2021.Recommanded Product: 404001-48-5 This article mentions the following:

Separation studies were conducted to sep. palladium (Pd) or platinum (Pt) from acidic solutions using 15 hydrophobic ionic liquids (ILs) capable of forming a binary phase with acidic aqueous solution This study considered two cases. The first was to find high-efficient ILs capable of separating metals from a single solution, and the second was to find ILs capable of selectively separating Pt from an acidic mixture solution of Pd and Pt. In addition, we also considered toxic effect of ILs for greener separation process. For this studies, we exptl. examined the separation efficiencies of the ILs, and discuss the properties with their toxicities, theor. predicted by previously presented toxicity prediction model, were compared. The results revealed that the extraction efficiency of ILs for Pd and Pt from acidic solutions depends on the types of IL and metal concentration In the separation study on Pd in a single metal solution, trihexyltetradecylphosphonium bromide [P6,6,6,14]Br and trioctylmethylammonium chloride [N8,8,8,1]Cl efficiently separates Pd from acidic solutions, while the separation on Pt in its single metal solution, 1-benzyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [IM1-1Bz][(CF₃SO₂)₂N], 1-methyl-3-dodecylimidazolim bis(trifluoromethylsulfonyl)imide [IM12][(CF₃SO₂)₂N], 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [IM16][(CF₃SO₂)₂N], [P6,6,6,14]Br and [N8,8,8,1]Cl led to high efficiencies. Moreover, in the study to selectively sep. Pt from a mixed solution of Pd and Pt, [IM1-1Bz][(CF₃SO₂)₂N] and [IM16][(CF₃SO₂)₂N] have significant separation efficiency. When comparing the efficiencies and toxicities of the two ILs, [IM1-1Bz][(CF₃SO₂)₂N] is more efficient, but it is more toxic than [IM16][(CF₃SO₂)₂N]. Thus, for sustainable development, [IM16][(CF₃SO₂)₂N] can be considered as a better option. Moreover, in order to understand the partitioning mechanisms of ILs we developed quant. structure-activity relationship models with R² values greater than 0.91. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Recommanded Product: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Systematic Investigation of a Surfactant Type Nano Gemini Ionic Liquid and Simultaneous Abnormal Salt Effects on Crude Oil/Water Interfacial Tension was written by Saien, Javad;Kharazi, Mona;Yarie, Meysam;Zolfigol, Mohammad Ali. And the article was included in Industrial & Engineering Chemistry Research in 2019.Quality Control of 1-Octyl-1H-imidazole This article mentions the following:

Gemini ionic liquids (ILs) are usually known to have significant surfactant behavior. Nanomaterials, on the other hand, are capable of improving interface properties. The current study explores the use of a novel nano gemini imidazolium IL with a mol. structure of a four methylene group spacer for reducing crude oil/water interfacial tension (IFT). The gemini IL was prepared purely by a two-step synthesis method and characterized in different ways. Results revealed that IFT was drastically decreased to 97.8% in the presence of the IL and more decrease was achieved with temperature and pH variations. The high performance of the IL can be attributed to the strong IL amphiphilic nature. The salt effects in the presence of the IL were evaluated with NaCl, MgCl₂, and their mixture Results revealed more IFT reduction under salinity conditions because of a remarkable found synergism effect, unlike conventional surfactants. The findings encourage the use of seawater IL solutions in chem. enhanced oil recovery. The obtained salt-free IFT data were precisely reproduced with the well-known Frumkin adsorption isotherm, and the corresponding thermodn. parameters were obtained at different temperatures From thermodn. results, a spontaneous IL adsorption was deduced. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Quality Control of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem