Author: Jessica.F

Editors’ choice-the effect of anchor group and alkyl backbone chain on performance of organic compounds as corrosion inhibitors for aluminum investigated using an integrative experimental-modeling approach was written by Milosev, I.;Zimerl, D.;Carriere, Ch.;Zanna, S.;Seyeux, A.;Iskra, J.;Stavber, S.;Chiter, F.;PoberZnik, M.;Costa, D.;Kokalj, A.;Marcus, P.. And the article was included in Journal of the Electrochemical Society in 2020.COA of Formula: C11H20N2 This article mentions the following:

An alk. etched, superhydrophilic Al surface was modified using functionalized alkyl compounds selected to study the effect of their properties on adsorption on the metal surface. The thirteen organic compounds differed in alkyl chain length (eight and eighteen C atoms) and anchor group (azide, imidazole, thiocyanate, amino, disulfide, thiol, phosphonic, carboxylic, and benzoic). The methodol. of the study integrated a complete chain of steps incorporating synthesis, electrochem. and surface analyses, and computational modeling. The corrosion resistant and superhydrophobic properties depend on the anchor group, which governs adhesion to the surface, and backbone, which is responsible for lateral cohesive interactions. The morphol. and chem. composition of modified layers were studied using SEM, XPS and time-of-flight secondary ion mass spectrometry. Electrochem. and long-term immersion properties were studied in 0.5M NaCl. Calculations based on d. functional theory were performed as to model the adsorption of selected anchor groups on the hydroxylated oxidized Al surface. Integrated results allowed the identification of the anchor groups that are able to form inhibitive adsorbed layers on Al surface regardless the alkyl chain length, and those that are not able to form adsorbed layers at all and are thus not efficient corrosion inhibitors. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective conjugate addition of hydroxylamines to 伪,尾-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex was written by Deng, Tao;Thota, Ganesh Kumar;Li, Yi;Kang, Qiang. And the article was included in Organic Chemistry Frontiers in 2017.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

A catalytic enantioselective hydroxyamination of 伪,尾-unsaturated 2-acyl imidazoles with N-protected hydroxyl amines catalyzed by a chiral-at-metal Rh(III) complex (0.5-2 mol%) has been developed. The approach affords valuable N-Boc protected 尾-amino acid derivatives I (R¹ = Me, i-Pr, Ph; R² = Me, Ph, 3-MeC₆H₄, etc.) in moderate to good yields with high enantioselectivity (up to 94% yield, 99.5% ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Upon the hydrogen-bonding ability of the H-4 and H-5 protons of the imidazolium cation was written by Abdul-Sada, Ala’a;Al-Juaid, Salih;Greenway, Anthony M.;Hitchcock, Peter B.;Howells, Matthew J.;Seddon, Kenneth R.;Welton, Thomas. And the article was included in Structural Chemistry in 1990.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

The crystal and mol. structures of [Me₂Etim]Cl, [Me₂Etim]₂[CoCl₄], and [Me₂Etim]₂[NiCl₄]([Me₂Etim]⁺ = 1,2-dimethyl-3-ethylimidazolium cation) all contain evidence that the H4 and H5 protons of the imidzolium cation enter into hydrogen bonds; the implications of this observation for the interactions in room-temperature chloroaluminate(III) ionic liquids are considered. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Performance-Determining Role of Lewis Bases in Dye-Sensitized Solar Cells Employing Copper-Bisphenanthroline Redox Mediators was written by Fuerer, Sebastian O.;Milhuisen, Rebecca A.;Kashif, Muhammad K.;Raga, Sonia R.;Acharya, Shravan S.;Forsyth, Craig;Liu, Maning;Frazer, Laszlo;Duffy, Noel W.;Ohlin, C. Andre;Funston, Alison M.;Tachibana, Yasuhiro;Bach, Udo. And the article was included in Advanced Energy Materials in 2020.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

Copper redox mediators have enabled open-circuit voltages (VOC) of over 1.0 V in dye-sensitized solar cells (DSCs) and have helped to establish DSCs as the most promising solar cell technol. in low-light conditions. The addition of additives such as 4-tert-butylpyridine (tBP) to these electrolytes has helped in achieving high solar cell performances. However, emerging evidence suggests that tBP coordinates to the Cu(II) species and limits the performance of these electrolytes. To date, the implications of this coordination are poorly understood. Here, the importance of Lewis base additives for the successful implementation of copper complexes as redox mediators in DSCs is demonstrated. Two redox couples, [Cu(dmp)₂]^+/2+ and [Cu(dpp)₂]^+/2+ (with dmp = 2,9-dimethyl-1,10-phenanthroline and dpp = 2,9-diphenyl-1,10-phenanthroline) in combination with three different Lewis bases, TFMP (4-(trifluoromethyl)pyridine), tBP, and NMBI (1-methyl-benzimidazole), are considered. Through single-crystal X-ray diffraction anal., absorption, and ¹H-NMR spectroscopies, the coordination of Lewis bases to the Cu(II) centers are studied. This coordination efficiently suppresses recombination losses and is crucial for high performing solar cells. If, however, the coordination involves a ligand exchange, as is the case for [Cu(dpp)₂]^+/2+, the redox mediator regeneration at the counter electrode is significantly retarded and the solar cells show current limitations. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Targeted and nontargeted screening and identification of 50 antihypertensive adulterants in dietary supplements and herbal medicines using quadrupole-orbitrap high resolution mass spectrometry with compound database was written by Guo, Changchuan;Niu, Chong;Zhou, Liming;Wang, Wenxin;Nie, Yanjun;Liu, Qi;Zhang, Lei;Chen, Zhen;Wang, Weijian;Xu, Yuwen. And the article was included in Journal of Separation Science in 2020.HPLC of Formula: 145040-37-5 This article mentions the following:

In the present work, a novel database of drug compounds and a rapid screening method based on ultra-high performance liquid chromatog. coupled to high resolution orbitrap mass spectrometry were developed and applied in the screening and identification of targeted and nontargeted antihypertensive adulterants in dietary supplements and herbal medicines. The established screening database includes retention time, exact mass, fragments, isotopic pattern, and MS² spectra library of the target compounds and thus provides automated search and identification of the targets with a single injection. The nontargeted compounds in the samples are identified through the full MS scan and MS² data by using the Chemspider database and the data anal. in XCalibur, MassFrontier and TraceFinder software. In addition, this method possesses excellent quant. capacity. The novel approach was applied to 65 batches of samples that are claimed as “all-natural” products having the antihypertensive function, among which nine batches were found to be pos. Multiple targeted and nontargeted antihypertensive adulterants were detected at levels ranging from 2.8 to 27.9 mg/g. The novel database and screening method demonstrated herein will be promising and powerful tools for rapid screening of antihypertensive adulterants in dietary supplements and herbal medicines. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5HPLC of Formula: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Facile C-H Insertion Strategy using Combination of HFIP and Isocyanides: Metal-Free Access to Azole Derivatives was written by Gujjarappa, Raghuram;Vodnala, Nagaraju;Reddy, Velma Ganga;Malakar, Chandi C.. And the article was included in Asian Journal of Organic Chemistry in 2020.Synthetic Route of C8H8N2 This article mentions the following:

An efficient metal-free approach has been devised towards the synthesis of azoles via C-H insertion protocol. Various isocyanides were examined as effective C1-synthons. The HFIP plays crucial role as hydrogen source and promoter of the reaction in order to reveal the maximum efficacies to accomplish the transformation in high yields of the products with excellent functional group tolerance. The control experiment affirmed 83% of deuterium incorporation, when the reaction was performed using HFIP-d₂. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A class of potent DPP-4 inhibitors was written by Eckhardt, Matthias;Hauel, Norbert;Himmelsbach, Frank;Langkopf, Elke;Nar, Herbert;Mark, Michael;Tadayyon, Moh;Thomas, Leo;Guth, Brian;Lotz, Ralf. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.HPLC of Formula: 74478-96-9 This article mentions the following:

Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors. In the experiment, the researchers used many compounds, for example, Ethyl 2,4-dibromo-1H-imidazole-5-carboxylate (cas: 74478-96-9HPLC of Formula: 74478-96-9).

Ethyl 2,4-dibromo-1H-imidazole-5-carboxylate (cas: 74478-96-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 74478-96-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The ionization constants of some imidazoles was written by Gallo, Gian Gualberto;Pasqualucci, Carmine Renato;Radaelli, Pietro;Lancini, Gian Carlo. And the article was included in Journal of Organic Chemistry in 1964.Application of 3034-41-1 This article mentions the following:

The basic and the acidic ionization constants of some imidazole derivatives have been determined spectrophotometrically or potentiometrically. For the nitroimidazoles, the spectrophotometric method has been used in concentrated sulfuric acid solutions, for which the Hammett acidity function, H₀, has been adopted. Tautomeric equilibrium constants of the imidazoles containing an imino H have been calculated The ionization constants have been correlated to the substituents and their position in the imidazole ring. The usefulness of pK_a measurements in assigning structures of these compounds is pointed out. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalyst selection by transition state affinity chromatography-an assessment was written by Tran, Anh T.;Rapp, Jacob T.;Nicholas, Kenneth M.. And the article was included in Molecular Catalysis in 2017.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

A new method for catalyst selection-optimization is introduced and evaluated, transition state affinity chromatog. (TSAC), based on the relative chromatog. affinity of pre-catalysts for a supported-substrate vs. a transition state analog (TSA). The affinities of a library of Zn-imine complexes on three designer HPLC affinity columns that possess either an immobilized substrate, a transition state analog or a non-binding reference compound are compared to their catalytic activities for picolinate ester hydrolysis. For those Zn-complexes whose ligands possess a hydroxyalkyl side chain the retention times on the substrate-affinity column correlate linearly with the catalyst-substrate affinity, 1/K_M, derived from the kinetics of the LZn-catalyzed hydrolysis of 4-nitrophenyl picolinate. Addnl., the kinetically determined esterolytic catalytic activities, k_cat, for the hydroxyalkyl-bearing complexes also correlate with their relative chromatog. affinity on the TSA- vs sub-affinity columns. Zinc-complexes that lack the hydroxyalkyl arm, however, show no correlation of their chromatog. behavior with 1/K_M and an inverse correlation with k_cat. These results are interpreted in terms of differences in the catalytic mechanisms for the two sets of catalysts. TSAC is shown to be viable for selecting the most active esterolytic Zn-catalyst from a mixture of five complexes. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Influence of different branched alkyl side chains on the properties of imidazolium-based ionic liquids was written by Erdmenger, Tina;Vitz, Juergen;Wiesbrock, Frank;Schubert, Ulrich S.. And the article was included in Journal of Materials Chemistry in 2008.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Several new branched ionic liquids were synthesized under microwave irradiation applying two different synthetic approaches. Different already known ionic liquids, both linear and branched, were added to this set of new ionic liquids to investigate the influence of the branching on the thermophys. properties to elucidate first structure-property relationships. Thermogravimetric anal. was utilized to investigate the decomposition behavior and differential scanning calorimetry was used to study the influence of the branching on the thermal behavior, e.g. the m.p., the glass transition temperature, the f.p. and the cold crystallization temperature Moreover, the water uptake of selected ionic liquids was analyzed. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem