Author: Jessica.F

Formulation and in-vitro evaluation of fast dissolving tablets of candesartan cilexetil was written by Kumar, Rajesh;Rai, Vishnu Kant. And the article was included in World Journal of Pharmaceutical Research in 2021.Electric Literature of C33H34N6O6 This article mentions the following:

From this study it is possible to design suitable fast dissolving tablets containing Candesartan Cilexetil for the treatment of psychoses with more effectiveness and better patient compliance. Further in-vivo investigations are required to correlate in-vitro drug release studies for the development of suitable rapid release system for Candesartan Cilexetil. Fast dissolving tablets prepared by the Crospovidone are promising for rapid release of Candesartan Cilexetil. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In Silico Screening and Testing of FDA-Approved Small Molecules to Block SARS-CoV-2 Entry to the Host Cell by Inhibiting Spike Protein Cleavage was written by Ozdemir, E. Sila;Le, Hillary H.;Yildirim, Adem;Ranganathan, Srivathsan V.. And the article was included in Viruses in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

The COVID-19 pandemic began in 2019, but it is still active. The development of an effective vaccine reduced the number of deaths; however, a treatment is still needed. Here, we aimed to inhibit viral entry to the host cell by inhibiting spike (S) protein cleavage by several proteases. We developed a computational pipeline to repurpose FDA-approved drugs to inhibit protease activity and thus prevent S protein cleavage. We tested some of our drug candidates and demonstrated a decrease in protease activity. We believe our pipeline will be beneficial in identifying a drug regimen for COVID-19 patients. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The proton magnetic resonance spectra of some diazoles, triazoles, and tetrazoles was written by Barlin, Gordon B.;Batterham, Thomas J.. And the article was included in Journal of the Chemical Society [Section] B: Physical Organic in 1967.Product Details of 3034-41-1 This article mentions the following:

The N.M.R. spectra of various charged species from 33 azoles have been measured. In N-methyl-imidazoles and -1,2,4-triazoles the sites of protonation have been determined, and the cations appear to be stabilized by amidinium type resonance. Solvent effects are discussed. 27 references. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cadmium(II) and lead(II) extraction and transport through polymer inclusion membranes with 1-alkylimidazole was written by Radzyminska-Lenarcik, Elzbieta;Pyszka, Ilona;Urbaniak, Wlodzimierz. And the article was included in Desalination and Water Treatment in 2021.COA of Formula: C11H20N2 This article mentions the following:

The formation of cadmium(II) complexes with hydrophobic 1-alkylimidazoles (1-hexylimidazole (1), 1-heptylimidazole (2), 1-octylimidazole (3), 1-decylimidazole (4) was tested by liquid-liquid partition method. On the basis of the extraction data, stability constants of cadmium(II) and Pb(II) complexes were determined It had been assumed that differences in the formation of cadmium(II) and lead(II) complexes with alkylimidazoles could be used to sep. those ions. The possibility of cadmium(II) and lead(II) ion separation in the transport through polymer inclusion membranes (PIMs) was examined PIMs comprising of cellulose triacetate, o-nitrophenylpentyl ether, and alkylimidazole (1-4) were used. The membranes were characterized using at. force microscopy (AFM). The results have shown that cadmium(II) ions are effectively transported through PIMs. The best result achieved for cadmium(II) removal from Cd(II)-Pb(II) solution for PIMs with (4) was 95.5% after 24 h. For this membrane, the separation coefficients for Cd(II)/Pb(II) were 1.62. Best Cd(II)/Pb(II) selectivity coefficients equal to 2.94 were found for (1). The influence of the basicity of carrier mols. on transport kinetics was discussed as well. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bridge-functionalized bisimidazolium bromides as catalysts for the conversion of epoxides to cyclic carbonates with CO₂ was written by Li, Yuanhui;Dominelli, Bruno;Reich, Robert M.;Liu, Boping;Kuhn, Fritz E.. And the article was included in Catalysis Communications in 2019.Recommanded Product: 1-Octyl-1H-imidazole This article mentions the following:

Six novel bridge-functionalized bisimidazolium bromides were synthesized and applied as catalysts for the cycloaddition of carbon dioxide and epoxides to give cyclic carbonates. Addnl., the influence of the hydrogen-bond donors, the N-wing-tip-substituents and the chain length of the connecting carbon bridges on the catalytic activity were studied. Catalyst bis[(trimethylphenyl)imidazoliumyl]methylpropanoic acid dibromide proved to be slightly more active than the reference catalyst bis(octylimidazoliumyl)propanol dibromide for the addition of carbon dioxide to various epoxides and could be analogously recycled from propylene carbonate for at least six times without distinct loss of activity. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mechanism of methylation of 4(or 5)-nitroglyoxaline by methyl sulfate was written by Grimison, A.;Ridd, J. H.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1956.Name: 1-Methyl-4-nitroimidazole This article mentions the following:

A kinetic study was undertaken under homogeneous conditions. The acidity of 4(or 5)-nitroglyoxaline (I) in water was determined from UV spectra, pK 9.22 in aqueous 10% EtOH containing 0.3-0.9N NaOH. The rate was k₂(Me₂SO₄) (G^–), where G^– is the conjugate base of I. The rate of concurrent hydrolysis of Me₂SO₄ (II) was k’₁(Me₂SO₄) + k’₂(Me₂SO₄) (OH^–). At 25掳, k₂ = 1.9 脳 10^-2; k’₂ = 1.6 脳 10^-2; k’₁ = 1.7 脳 10^-1, all in moles 1.^-1 sec.^-1 Kinetic results point to nucleophilic attack by G^– on II, the product being the 1,4-isomer, in contrast to the 1,5-isomer obtained in acidic media, which also causes a different reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Name: 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Disclosure of mystery of “fairy rings” by chemistry was written by Kawagishi, Hirokazu. And the article was included in Yuki Gosei Kagaku Kyokaishi in 2015.Reference of 26832-08-6 This article mentions the following:

A review on chems. responsible for “fairy rings” of turf grass, their formation through a new purine metabolic pathway, and chem. synthesis of ¹³C,¹⁵N-labeled metabolites. 2-Azahypoxanthine (AHK, I) (rice plant-growth promotor) and imidazole-4-carboxamide (ICA, II) (turf grass growth inhibitor) were isolated from a fairy-ring forming fungus Lepista sordida. AHK was converted into a metabolite, 2-aza-8-oxohypoxanthine (AOH, III) (turf grass growth-promoters), in plants. Afterward, it turned out that these three compounds, fairy chems. (FSc), endogenously exist in plants and are biosynthesized via a new purine metabolic pathway. Furthermore, FCs increased the yields of rice, wheat and other crops in the field experiments In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Reference of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Layered organic-inorganic hybrid materials based on ionic liquid and lead chloride: Insights into the structure and properties was written by Balachandran, Nisha;Suseeladevi, Asha;Periya, Vijayalakshmi Kunduchi;Robert, Temina Mary;Soundiraraju, Bhuvaneswari;Cyriac, Jobin;Mathew, Dona. And the article was included in Journal of Molecular Liquids in 2020.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Layered organic-inorganic hybrid materials are an emerging class of materials with excellent stability and outstanding optoelectronic properties. Here, we report the synthesis, characterization and optical properties of hybrid materials formed from lead chloride (PbCl₂)-methylimidazolium chloride (MimCl) and PbCl₂-alkyl methylimidazolium chlorides (AmimCl) of varying alkyl chain lengths viz. Et (C₂mimCl), Bu (C₄mimCl) and hexyl (C₆mimCl). The molar ratio of PbCl₂ to MimCl and AmimCl had a profound influence on the formation and properties of two-dimensional (2D) hybrid materials. The conformations and structural aspects of the synthesized materials with varying substitutions were extensively evaluated and correlated using computational studies. MimCl-PbCl₂, C₂mimCl-PbCl₂ and C₆mimCl-PbCl₂ forms 2D structures while C₄mimCl-PbCl₂ was forming 2D and 1D structures as evident from topog. and morphol. evaluations through at. force microscopy (AFM) and transmission electron microscopy (TEM). The materials synthesized were non-hygroscopic and exhibited excellent thermal stability. The AmimCl-PbCl₂ shows absorption in the UV region with the onset extends to the visible range and exhibits good photoluminescence at 532 nm. These hybrid materials showed a charge carrier lifetimes (10-40 ns) and a photoresponse (photocurrent of the order microamperes) which make them a potential candidate for optoelectronic devices. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A mixed matrix Eu-4,4′-biphenyldicarboxylate coordination polymer film as a fluorescence turn-off sensor to aniline vapor was written by Shen, Mei Lin;Wei, Zhen;Xu, Ling;Liu, Bing;Jiao, Huan. And the article was included in Journal of Solid State Chemistry in 2019.Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The ionothermal reaction of EuCl₃ with 4,4′-biphenyldicarboxylic acid (H₂BPDC) produced a 3-dimensional fluorescence coordination polymer (CP), [PMI]₂[Eu₂(BPDC)₃Cl₂] (1). 1 Was dispersed onto the bandage, and further infiltrated by polyvinylidene fluoride (PVDF) to give a mixed matrix 1@PVDF/bandage composite film (1-film). The fluorescence and the morphol. indicate 1-film can emit red fluorescence and the CP particles are on the surfaces of bandage fabrics with the adhesion of PVDF. The fluorescence of 1-film can be quenched by different amines in the order of aliphatic amine > aromatic amine > alc. amine > amide, which concerns with the amine sizes. 1-film shows a fast response and selective sensing to aniline vapor, suggesting it may be a fluorescence turn-off sensor to aniline vapor. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvent Water Content as a Factor in the Design of Metal Ion Extraction Systems Employing Ionic Liquids was written by Hawkins, Cory A.;Rigney, Madison L.;Rud, Anna;Dietz, Mark L.. And the article was included in Solvent Extraction and Ion Exchange in 2018.SDS of cas: 21252-69-7 This article mentions the following:

In the extraction of strontium nitrate from aqueous nitric acid solutions into a series of hydrophobic N-(1-hydroxyalkyl)-N’-alkylimidazolium bis[(trifluoromethyl)sulfonyl]imides by dicyclohexano-18-crown-6, a correlation has been demonstrated between the conditional extraction constant of strontium (K’_ex,Sr) and the concentration of water in the equilibrated ionic liquid (IL) phase. Despite the absence of a hydroxyl group on the IL cation, essentially the same relationship is observed for the analogous N,N’-dialkylimidazolium ILs. In both instances, the correlation is attributed to the coextn. of the hydrated nitrate ion and its solvation by the hydrated diluent. Transitions of water in the attenuated total reflectance-IR spectra of the ILs are consistent with the existence of multiple states of water. The extraction efficiency for a given water content is greater for the ILs examined than for conventional solvents (i.e., n-alcs.). When coupled with existing knowledge of the factors influencing cation partitioning into ILs, these results provide insight into the IL structural characteristics required to effect efficient metal ion extraction from acidic media. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7SDS of cas: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem