Author: Jessica.F

EPR and polarography of nitro azoles. 2. Nitroimidazoles was written by Vakul’skaya, T. I.;Larina, L. I.;Nefedova, O. B.;Petukhov, L. P.;Voronkov, M. G.;Lopyrev, V. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1979.Name: 1-Methyl-4-nitroimidazole This article mentions the following:

Polarog. half-wave potentials (E) were determined for I (R = H, Me, Et; R¹ = H, Me), II (R = Me, Et; R¹ = H, Me), and III (R = H, Me, Et), and ESR parameters were determined for the resulting anion radicals. When R in I, II, and III was H, dianion radicals were formed in a stepwise manner; when R was alkyl, monoanion radicals were formed. The magnitude of a^NO2 increased with increasing magnitude of E. In the dianion radicals >60% of the spin d. was concentrated on the NO₂ group; in the monoanion radicals this figure was 45-50%. The degree of spin d. transfer to the ring decreased in the order III > II > I. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Name: 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cation Symmetry effect on the Volatility of Ionic Liquids was written by Rocha, Marisa A. A.;Coutinho, Joao A. P.;Santos, Luis M. N. B. F.. And the article was included in Journal of Physical Chemistry B in 2012.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

This work reports the first data for the vapor pressures at several temperatures of the ionic liquids, [C_N/2C_N/2i.m.][NTf₂] (N = 4, 6, 8, 10, 12) measured using a Knudsen effusion apparatus combined with a quartz crystal microbalance. The morphol. and the thermodn. parameters of vaporization derived from the vapor pressures, are compared with those for the 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide series, [C_N-1C₁i.m.][NTf₂] (N = 3 – 9, 11, and 13). It was found that the volatility of [C_N/2C_N/2i.m.][NTf₂] series is significantly higher than the asym. cation ILs with the same total number of carbons in the alkyl side chains, [C_N-1C₁i.m.][NTf₂]. The observed higher volatility is related with the lower enthalpy of vaporization. The sym. cation, [C_N/2C_N/2i.m.][NTf₂], presents lower entropies of vaporization compared with the asym. [C_N-1C₁i.m.][NTf₂], indicating an increase of the absolute liquid entropy in the sym. cation ILs, being a reflection of a change of the ion dynamics in the IL liquid phase. Moreover both the enthalpy and entropy of vaporization of the [C_N/2C_N/2i.m.][NTf₂] ILs, present a clear odd-even effect with higher enthalpies/entropies of vaporization for the odd number of carbons in each alkyl chain ([C₃C₃i.m.][NTf₂] and [C₅C₅i.m.][NTf₂]). In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Methylation of benzimidazole- and benzothiazolecarboxaldoximes was written by Poziomek, E. J.;Poirier, R. H.;Morin, R. D.;Page, T. F. Jr.. And the article was included in Journal of Organic Chemistry in 1963.Related Products of 3012-80-4 This article mentions the following:

Conversion of 1,2-dimethylbenzimidazole, m. 109-10掳, gave 1-methylbenzimidazole-2-carboxaldehyde, m. 107-8掳, 位 5.9 渭; oxime m. 224-5掳. The oxime (0.3 g.) kept 2 days at 20掳 with excess MeI in MeOH-EtOH gave 0.1 g. 1,3-dimethyl-2-formylbenzimidazolium iodide oxime (I), m. 204-5掳 (decomposition). Benzothiazole-2-carboxaldehyde, m. 75-6掳 (petr. ether), recrystallized from MeOH to give the hemiacetal, m. 89-91掳, gave the corresponding oxime (II), m. 168-9掳. II (11.5 g.) and 24.6 g. MeI in 75 ml. 4:1 PhNO₂-EtOH refluxed 11 hrs. and the solution kept 1 week at 20掳, filtered and the residual red-brown solid (11.0 g.) boiled in 300 ml. MeOH with activated C, the solution gradually diluted with Et₂O and cooled gave 0.4 g. N-methyl-2-formyl-3-methylbenzothiazolium iodide oxime (III, R = Me) (IV), m. 226-8掳, 7.6 g. mixture, m. 198-200掳, containing 75% 2-formyl-3-methylbenzothiazolium iodide oxime (V); and 1.0 g. V, m. 203-4掳 (decomposition), neutralization equivalent 322, pK_a 6.3 (H₂O), 位 329 m渭 (0.1N HCl), 位 363 m渭 (0.1N NaOH). The more facile synthesis of I than of V was understandable in light of the more basic center in the 1-methylbenzimidazole ring. Failure to find hydriodides III (R = H) or the MeO compound (VI, R = H) indicated that the ring N atoms were not hindered sterically to any serious extent. II (2.4 g.) and 5 ml. MeI refluxed 24 hrs. in 15 ml. MeOH and the concentrated solution diluted with Et₂O, separated from 1.3 g. solid, m. 189-90掳 (decomposition), and the filtrate evaporated, the recovered II (1.6 g.) refluxed 6 hrs. in MeOH with MeI and the product (0.3 g.) isolated, the 2 crops (1.6 g.) taken up in 100 ml. MeOH-EtOH and treated with Norit, the filtered solution concentrated to 50 ml. and cooled yielded 28% V. II (5.0 g.) in 100 ml. hot MeOH treated with 8 g. MeONH₂.HCl and the mixture heated 30 min. on a steam bath, diluted to incipient cloudiness, and cooled gave 4.6 g. O-methylbenzothiazole-2-carboxaldoxime, m. 65-8掳, converted (4.0 g.) by refluxing 85 hrs. with 10 ml. MeI in 75 ml. MeOH and diluting the cooled mixture with Et₂O to give 0.6 g. orange VI (R = Me). Similarly II was converted by use of HONHMe.HCl to give 26% IV, m. 233-5掳, exhibiting an infrared spectrum identical with the side-product isolated in the methylation of II. The nuclear magnetic resonance spectrum of I in D₂O gave a singlet at 522 cycles/sec., a sym. multiplet at 468 cycles/sec., and a single sharp peak at 249 cycles/sec. The :NOH proton resonance at 740 cycles/sec. was observed in redistilled dry MeCN. Structure proof of V was achieved on the basis of elemental analyses, neutralization equivalent, and infrared and ultraviolet spectral observations. I, pK_a 7.0, and V, pK_a 6.3, are the most acidic of the reported heterocyclic aldoxime methiodides. The low pK_a of I relative to the high basicity of its heterocyclic nucleus was discussed in terms of configuration and ring substitution position. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A quantum mechanical study of alkylimidazolium halide ionic liquids was written by Li, Wei;Qi, Chuansong;Rong, Hua;Wu, Xinmin;Gong, Liangfa. And the article was included in Chemical Physics Letters in 2012.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Thirty imidazolium (IM) halide compounds were studied using DFT methods (B3LYP, B3P86, and PBE1PBE1) methods. Geometry optimization and interaction energy calculations were performed using the B3LYP/6-311++G(d,p) method for ions composed of one alkylimidazolium cation and two or three halogen anions. The obtained structures were consistent with exptl. results. In addition, a linear correlation between m.ps. and interaction energies was obtained for the compounds studied, and this relationship was consistent with that obtained for amino acid cation based ionic liquids In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of validated stability indicating RP-HPLC method for simultaneous estimation of amlodipine besylate and candesartan cilexetil from tablet was written by Padole, Y. F.;Rabade, S. K.;Jirvankar, P. S.;Umekar, M. J.;Lohiya, R. T.. And the article was included in World Journal of Pharmaceutical Research in 2021.Category: imidazoles-derivatives This article mentions the following:

A simple, isocratic, rapid and accurate reversed phase high performance liquid chromatog. method was developed for the quant. determination of Candesartan Cilexetil and Amlodipine Besylate tablets. The chromatog. separation was achieved on Water Xterra R18, 150×4.6 mm, 3.5u (C18) using Mobile Phase A : ACN: Water: OPA (950:50:01) and Mobile Phase B: ACN: Water: OPA (50:950:01), and the 位_max of Amlodipine Besylate was detected at 237nm, where Candesartan Cilexetil exhibits sufficient absorbance at 254 nm. The linear range for Candesartan Cilexetil and Amlodipine Besylate were (2.8-42ppm) and (6.4-96) was obtained with correlation coefficients 鈮?.999 for each analyte. The retention time were found to be 4.2 and 8.5 min Candesartan Cilexetil and Amlodipine Besylate resp. Candesartan Cilexetil and Amlodipine Besylate was subjected to stress conditions (hydrolysis (acid, base) oxidation, photolysis, thermal degradation and humidity degradation) and the stressed samples were analyzed by use of the method. The major degradation was observed in base and minor in acid, thermal, oxidation, humidity and photolysis. The forced degradation studies prove the stability indicating power of the method. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Category: imidazoles-derivatives).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent was written by Maroz, Andrej;Shinde, Sujata S.;Franzblau, Scott G.;Ma, Zhenkun;Denny, William A.;Palmer, Brian D.;Anderson, Robert F.. And the article was included in Organic & Biomolecular Chemistry in 2010.Reference of 3034-41-1 This article mentions the following:

The one-electron reduction chem. of the antituberculosis drug PA-824, together with a series of closely related compounds, has been investigated in irradiated anaerobic propan-2-ol solution The protic solvent, of low dielec. constant, was chosen to mimic the environment of a water-restricting active site of a model protein, which is capable of reducing the compounds Radiolytic reduction of the compounds containing electron donating substituents in the 2-position of the imidazole ring released nitrite, with compounds that are highly active against Mycobacterium tuberculosis exhibiting high yields of nitrite. The release of cytotoxic reactive nitrogen species through a one-electron pathway, by as yet unidentified proteins, may play a role in the activity of this class of compounds against TB. The described radiolytic quantification of nitrite release may have utility as a preliminary screening test for nitroarom. candidate drugs against the disease. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluations of imidazolium ionic liquids as novel skin permeation enhancers for drug transdermal delivery was written by Zhang, Ding;Wang, Huai-Ji;Cui, Xiu-Ming;Wang, Cheng-Xiao. And the article was included in Pharmaceutical Development and Technology in 2017.Category: imidazoles-derivatives This article mentions the following:

In this work, imidazolium ionic liquids (imidazolium ILs) were employed as the novel chem. permeation enhancers (CPEs) and their performances and mechanisms of action were deeply investigated. Testosterone was used as a model drug to investigate the transdermal delivery enhancement of twenty imdidazolium ILs. The results suggested that the promotion activity connected to the structure and composition of the ILs. The quant. structure-activity relationship (QSAR) model revealed a good linearity between the electronic properties of ILs and their enhancements. Furthermore, the transepidermal water loss (TEWL) and scanning laser confocal microscope (CLSM) examinations showed the strong improvement of ILs on skin barrier permeability, which were well correlated with the drug penetration profiles. The total reflection-Fourier transform IR spectroscopy (ATR-FTIR) and at. force microscope (AFM) evaluations of skins indicated that the ILs can disrupt the regular and compact arrangements of the corneocytes, change the surface properties of stratum corneum, and make the skin structure more permeable. Our work demonstrated the significant skin permeation promotion profiles of the imidazolium ILs, which are of great potential in transdermal drug delivery systems. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Category: imidazoles-derivatives).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies was written by Sharma, Pankaj;Thummuri, Dinesh;Reddy, T. Srinivasa;Senwar, Kishna Ram;Naidu, V. G. M.;Srinivasulu, Gannoju;Bharghava, Suresh K.;Shankaraiah, Nagula. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

A new series of (E)-[(benzo[d]imidazol-2-yl)methylene]indolin-2-one derivatives has been synthesized and evaluated for their in vitro cytotoxic activity against a panel of selected human cancer cell lines of prostate (PC-3 and DU-145) and breast (BT-549, MDA-MB-231, MCF-7, 4T1), non-small lung (A549) and gastric (HGC) cancer cells along with normal breast epithelial cells (MCF10A). Among the tested compounds, 8l (I) showed significant cytotoxic activity against MDA-MB-231 and 4T1 cancer cells with IC₅₀ values of 3.26 卤 0.24 渭M and 5.96 卤 0.67 渭M resp. The compounds 8f (II), 8i (III), 8l (I) and 8o (IV) were also screened on normal human breast epithelial cells (MCF10A) and found to be safer with lesser cytotoxicity. The treatment of MDA-MB-231 cells with 8l led to inhibition of cell migration ability through disruption of F-actin protein assembly. The flow-cytometry anal. reveals that the cells arrested in G0/G1 phase of the cell cycle. Further, the compound 8l induced apoptosis of MDA-MB-231 cells was characterized by different staining techniques such as Acridine Orange/Ethidium Bromide (AO/EB), DAPI, annexin V-FITC/PI, Rhodamine-123 and MitoSOX red assay. Western blot studies demonstrated that the compound 8l treatment led to activation of caspase-3, increased expression of cleaved PARP, increased expression of pro-apoptotic Bax and decreased expression of anti-apoptotic Bcl-2 in MDA-MB-231 cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nanocage formation and structural anomalies in imidazolium ionic liquid glasses governed by alkyl chains of cations was written by Bakulina, Olga D.;Ivanov, Mikhail Yu.;Prikhod’ko, Sergey A.;Pylaeva, Svetlana;Zaytseva, Irina V.;Surovtsev, Nikolay V.;Adonin, Nicolay Yu.;Fedin, Matvey V.. And the article was included in Nanoscale in 2020.Synthetic Route of C7H13ClN2 This article mentions the following:

Intriguing nanostructuring anomalies have been recently observed in imidazolium ionic liquids (ILs) near their glass transition points, where local d. around a nanocaged solute progressively grows up with temperature Herewith, we for the first time demonstrate exptl. and theor., that these anomalies are governed by alkyl chains of cations and crucially depend on their length. ESR spectroscopy on a series of ILs [C_nmim]BF₄ (n = 0-12) shows that only the chains with n = 3-10 favor anomaly. Moreover, remarkable even vs. odd n peculiarities were systematically observed Finally, similar anomaly was for the first time observed for a non-IL glass of di-Bu phthalate, which structurally mimics cations of imidazolium ILs. Therefore, such anomalous d. behavior in a glassy state nanocage goes far beyond ILs and proves to be a more general phenomenon, which can be structurally tuned and rationally adjusted for various potential applications in nanoscale materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Synthetic Route of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Systematic estimation and interpretation of fractional free volume in 1-alkyl-3-methylimidazolium-based ionic liquids was written by Endo, Takatsugu;Nishisaka, Yuji;Kin, Youn;Kimura, Yoshifumi. And the article was included in Fluid Phase Equilibria in 2019.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

With the aim of providing a plausible explanation for fractional free volume (FFV) behavior in ionic liquids (ILs) such as 1-alkyl-3-methylimidazolium-based cations paired with common anions like [BF₄]^–, [PF₆]^–, and bis(trifluoromethane)sulfonamide ([NTf₂]^–), we comprehensively estimated the van der Waals volume of the ions and subsequently determined the FFV behavior present within these liquids with the aid of quantum chem. calculations Unlike the values seen in previous studies, our results showed an increase in the FFV character of the IL under investigation when either the cations alkyl chain was lengthened and/or the size of the anion was expanded. The sizes of cations and anions present in the IL were shown to affect the FFV values in different ways: whereas the effect of the anions size could be accounted for by looking at changes in the Coulomb interaction between cations and anions in the polar (charge localized) domains, the effect exerted by the alkyl chain was found to be related to the alkyl chains dependence on the FFV obtained for alkanes due to the introduction of non-polar (alkyl group aggregated) domains to ILs with increasing alkyl chain lengths. An empirical equation was proposed in order to calculate FFV values for alkyl-imidazolium-based ILs. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem