Author: Jessica.F

Thermodynamics and limiting activity coefficients measurements for organic solutes and water in the ionic liquid 1-dodecyl-3-methylimidzolium bis(trifluoromethylsulfonyl) imide was written by Domanska, Urszula;Wlazlo, Michal. And the article was included in Journal of Chemical Thermodynamics in 2016.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Bio-fuels like alcs., including butan-1-ol are produced from biomass by fermentation, and distillation Ionic liquids (ILs) are novel attractive solvents, which can be used for removing butan-1-ol from the aqueous fermentation broth. In this work, the 1-dodecyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide, [DoMIM][NTf₂] is proposed as an extractive solvent. The temperature of fusion and the enthalpy of fusion, obtained with DSC, the d. and viscosity of [DoMIM][NTf₂] as a function of temperature have been measured over a temperature range (298.15-368.15) K. The limiting activity coefficients γ^∞₁₃, for 65 solutes including alkanes, cycloalkanes, alkenes, alkynes, aromatic hydrocarbons, alcs., water, thiophene, THF, ethers, and ketones in the [DoMIM][NTf₂] were determined by gas-liquid chromatog. at six temperatures from 318.15 K to 368.15 K. The partial molar excess Gibbs energies ΔG^E,∞₁, enthalpies ΔH^E,∞₁, and entropies ΔS^E,∞₁ at infinite dilution were calculated from the exptl. γ^∞₁₃ values obtained over the temperature range. The gas-liquid partition coefficients, K_L were calculated for all solutes and the Abraham solvation parameter model was discussed. The selectivity and capacity for butan-1-ol/water separation problem were calculated from γ^∞₁₃ and compared to literature values for bis{(trifluomethyl)sulfonyl}imide-based ILs with different cations and with all available data for ILs. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Poly(ionic liquid) Bridge Joining Smectic Lamellar Conducting Channels in Photoelectrochemical Devices as High-Performance Solid-State Electrolytes was written by Wang, Caihong;Li, Xueyong;Zhou, Jiwen;Tian, Wen;Ji, Junyi;Wu, Yong;Tan, Shuai. And the article was included in ACS Applied Energy Materials in 2021.Recommanded Product: 1632-83-3 This article mentions the following:

Nanostructured ionic liquid crystals have emerged as promising electrolytes with the potential to satisfy the demands of both efficient charge transport and stability over conventional liquid electrolytes for advanced energy devices. However, traditional methods via the macroscopic orientation of ionic liquid crystals for charge transport intensification can hardly be achieved during practical device applications. Herein, a simple method was proposed to spontaneously construct long-range continuous conducting channels for significantly improving the charge transport of ionic liquid crystals in the confined space of energy devices. A poly(imidazolium ionic liquid) was designed and in situ prepared in a smectic [C14MIm][I]-based electrolyte for photoelectrochem. device fabrication. The composite solid-state electrolyte self-assembled microphase-segregation nanostructures, wherein the poly(ionic liquid) aggregated at the boundaries of layered smectic polydomains. The imidazolium iodide ions in the poly(ionic liquid) acted as imbedded ion tunnels at domain interfaces via π-π stacking and ionic interaction, which facilitated the charge transport crossing the interfacial gaps to join the intradomain lamellar channels as thermally stable and long-range continuous charge transport pathways. By using the poly(ionic liquid) to bridge the domain-interfacial gaps, the ion conductivity of the ionic liquid crystals was up to 7 times increased with a maximum value of 2.0 x 10^-3 S cm^-1, and the derived dye-sensitized solar cell could operate stably at 70 °C with a 2-times enhancement and champion efficiency of 8.2%. The approach here was comparable but more processable to traditional methods via the macroscopical orientation of ionic liquid crystals for charge transport intensification within energy devices, which have great potential to develop high-performance solid-state electrolytes to achieve the best balance between efficiency and durability for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactions of organic anions. Part 143. Vicarious nucleophilic substitution of hydrogen in imidazole derivatives was written by Makosza, Mieczyslaw;Kwast, Ewa. And the article was included in Bulletin of the Polish Academy of Sciences, Chemistry in 1987.Quality Control of 1-Methyl-4-nitroimidazole This article mentions the following:

Nitroderivatives of imidazole react with carbanions containing leaving groups at the carbanion center yielding products of vicarious nucleophilic substitution of H at positions activated by the nitro group. Thus, nitroimidazole I reacted with PhSO₂CH₂Cl in the presence of KOH in Me₂SO to give derivative II. Some aspects of the orientation pattern of substitution are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Quality Control of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A regiospecific rearrangement of 4(5)-substituted 2-phenacylthio-1H-imidazoles to 4-substituted 2-mercapto-1-phenacyl-1H-imidazoles was written by Chakrabarti, Jiban K.;Smith, Colin W.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1991.Formula: C6H8N2O2S This article mentions the following:

4(5)-Substituted 2-phenacylthio-1H-imidazoles I (R = CO₂Et, Ph) thermally rearrange to give 2-mercapto-1-phenacyl-1H-imidazoles II. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of heteroxanthine from a derivative of imidazole was written by Sarasin, J.;Wegmann, E.. And the article was included in Helvetica Chimica Acta in 1924.Application In Synthesis of 1-Methyl-4-nitroimidazole This article mentions the following:

S. and W. describe a new synthesis of 7-methylxanthine from an imidazole derivative, by closing the pyrimidine ring, an operation which has not been previously effected. 1-Methyl-4-nitro-5-chloroimidazole (I) is obtained in theoretical yield from 1-methyl-5-chloroimidazole (b. 200°) (II) by dissolving in dilute HNO₃ to form the nitrate, treating the latter with cold concentrated H₂SO₄, heating the mixture on the water bath for 2 hrs., and pouring the product on ice; it m. 147-8°, and is insoluble in acids and dilute alkalies. The isomeric 1-methyl-5-nitro-4-chloroimidazole (III), obtained by the same method from 1-methyl-4-chloroimidazole; m. 77-8°. I and III are reduced at 0° by Sn and HCl to the corresponding methylchloroaminoimidazoles which were not obtained in the pure state. I heated for several hrs. on the H₂O bath in EtOH with 2 mols. KCN and 0.1 mol. KI yields 85% 1-methyl-4-nitro-5-cyanoimidazole (IV), m. 141-2°, insoluble in acids and dilute alkalies. 1-Methyl-4-nitroimidazole-5-carboxamide (V), obtained in 90% yield when IV is heated for 2 hrs. on the H₂O bath with 8 times its weight of concentrated H₂SO₄ and the product is poured on ice, m. 257-8° (decomposes), insoluble in acids and alkalies, saponified with great difficulty; a small amount of the acid (VI) is obtained by prolonged action of concentrated HCl. VI m. 160° with evolution of CO₂ and formation of 1-methyl-4-nitroimidazole (VII), m. 133-40°, which is also obtained by heating V in a sealed tube at 120° with HCl. Reduction of VII by Sn and HCl at 0° and hydrolysis of the product by heating under pressure with HCl, gives NH₄Cl and sarcosine-HCl, m. 168-9°; this reaction establishes the constitution of II and VII. V is reduced at 0° by Sn and HCl to the corresponding amine, 1-methyl-4-aminoimidazole-5-carboxamide (VIII), m. 184-5°, decomposed when heated with water or dilute alkalies with evolution of NH₃; HCl salt, m. 214-5°. 7-Methylxanthine (heteroxanthine) obtained in 38% yield by heating 0.4 g. of VIII for 8 hrs. in a sealed tube at 160-70° with an equal weight of CO(OEt)₂, m. 380° (browning and evolution of gas). A mixture of the substance with heteroxanthine prepared from theobromine melts at the same temperature The murexide reaction is given with KClO₃ and HCl. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application In Synthesis of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The synthesis of heterocycles via addition-elimination reactions of 4- and 5-aminoimidazoles was written by Al-Shaar, Adnan H. M.;Chambers, Robert K.;Gilmour, David W.;Lythgoe, David J.;McClenaghan, Ian;Ramsden, Christopher A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1992.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

4-Aminoimidazoles, e.g. I (R = H, R¹ = H, Me, CH₂Ph; R² = H, Me, Et, CHMe₂), undergo addition elimination reactions with electrophilic reagents to give exclusively N-adducts, which are useful intermediates for further synthetic transformations to novel heterocyclic systems. Thus, di-Et ethoxymethylenemalonate (II) and 4-amino-1-benzylimidazole give the adduct I [R = HC:C(CO₂Et)₂, R¹ = CH₂Ph, R² = H], and subsequent acid-catalyzed cyclization gives the imidazo[4,5-b]pyridine III and a heterocyclic mesomeric betaine, which undergoes 1,3-dipolar cycloaddition with di-Me acetylenedicarboxylate to give two products. When the 2-alkyl-4-aminoimidazoles I (R = R¹ = H, R² = Me, Et, CHMe₂) are generated in situ in the presence of II, 5,5′-diimidazoles are significant products; a mechanism for this novel transformation is proposed. 4-Amino-3-cyanoimidazo[1,5-a]pyrimidines IV (R = H, Me) are formed by cyclization of the N-adduct of I (R = R¹ = R² = H) and CR³(OEt):C(CN)₂ (R³ = H, Me). The use of X:NCN [V; X = CH(OEt), CMe(OEt), C(SMe)₂] leads to novel 4-aminoimidazo[1,5-a]-1,3,5-triazine derivatives VI (R¹ = H, Me, SMe; R² = H, Me), whose chem. reactions with both electrophilic and nucleophilic reagents are reported. 5-Aminoimidazoles, e.g., VII (R = H, R¹ = Me, CH₂CH₂OH; R² = Me, CHMe₂), undergo addition-elimination reactions with the electrophilic reagents, e.g. II and V, to give N-adducts and/or C-adducts, depending upon the structure of the reagent. These stable addition-elimination products are usually obtained in good yield and are useful intermediates for further synthesis. Reaction of the amines VII with II gives mainly N-adducts VII [R = HC:C(CO₂Et)₂], which can be cyclized using phosphoryl chloride to give the versatile 7-chloroimidazo[4,5-b]pyridines VIII. With ethoxymethylenemalononitrile, the amines VII give C-adducts, which undergo thermal cyclization to give 5-amino-6-cyanoimidazo[4,5-b]pyridines IX, which are further transformed into novel heterocyclic systems, including the tricyclic imidazo[4′,5′:5,6]pyrido[2,3-d]pyrimidines X (R = H, Ph) and XI (R = H, Bu, CH₂Ph, CH₂CH₂OH). Cyclization of the adducts obtained using V provides new synthetic route to aminopurine derivatives, e.g. XII (R³ = H, NH₂, SMe), and hypoxanthines. The preference of electrophilic reagents for N– or C-addition to VII is rationalized using Frontier MO theory. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquids as coagents for sulfur vulcanization of butadiene-styrene elastomer filled with carbon black was written by Maciejewska, Magdalena;Zaborski, Marian. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2018.Application of 404001-48-5 This article mentions the following:

The aim of this work was to study the activity of several alkylimidazolium salts of bis(trifluoromethylsulfonyl)imides to obtain a very fast vulcanization of the butadiene-styrene (SBR) elastomer. Ionic liquids (ILs) such as alkylimidazolium salts with ethyl-, propyl-, butyl-, hexyl-, decyl-, dodecyl-, and hexadecyl chains in the cation together with nanosized zinc oxide are used to develop elastomer composites with very short vulcanization time and a reduced amount of vulcanization activator. In this article, we discuss the effect of the ILs with respect to the length of alkyl chain in their cation on the vulcanization kinetics of rubber compounds The influence of ILs on the crosslink d. as well as the mech. properties of the vulcanizates and their resistance to thermo-oxidative and UV aging were also studied. ILs resulted in a shortened optimal vulcanization time and reduced the onset vulcanization temperature compared to zinc oxide containing rubber compound This is very important from a technol. point of view. A considerable increase in the crosslink d. of vulcanizates was also observed In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CNDO/S method interpretation of ultraviolet spectra of 4-nitro and 5-nitroimidazoles was written by Crozet, M. P.;Vanelle, P.;Bouscasse, L.;Avignon, T.. And the article was included in Spectroscopy Letters in 1986.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The UV spectra of several nitroimidazoles are reported. These exptl. results are interpreted using CNDO/S method (CNDO for Spectroscopy). Observed transitions are π → π^* type transitions. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Efficient synthesis of styrene carbonate from CO₂ and styrene oxide using zinc catalysts immobilized on soluble imidazolium-styrene copolymers was written by Qiao, Kun;Ono, Fumitaka;Bao, Quanxi;Tomida, Daisuke;Yokoyama, Chiaki. And the article was included in Journal of Molecular Catalysis A: Chemical in 2009.HPLC of Formula: 915358-85-9 This article mentions the following:

Preparation of zinc catalysts (Zn/PS-IL[X], X = Br^–, Cl^–, BF₄ ^–, and PF₆ ^–) supported on imidazolium-styrene copolymers, as well as their catalytic use for the solvent-free synthesis of styrene carbonate from CO₂ and styrene oxide, are described. Among the catalysts examined, Zn/PS-IL[Br] was proved to be the most efficient. When used in a homogeneous system during the reaction process, Zn/PS-IL[Br] gave a 97.5% yield of product with a TOF value that can be up to about 3800 h^-1. Due to its immiscibility with ethanol, Zn/PS-IL[Br] can be separated like a heterogeneous catalyst through solvent precipitation, and reused at least three times for the reaction without significant loss of activity. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9HPLC of Formula: 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of polysiloxane random copolymers that contain quaternized imidazolium moieties was written by Ichikawa, Tsukasa;Nemoto, Nobukalsu. And the article was included in Kobunshi Ronbunshu in 2016.Electric Literature of C11H20N2 This article mentions the following:

Polysiloxane random copolymers that contain quaternized imidazolium salts ([PImn]Cl) (n is the number of methylene groups) were obtained by the quaternization reaction of poly[dimethylsiloxane-ran-(3-chloropropylmethylsiloxane)] (P1) with imidazole derivatives having different lengths of alkyl chains (Imn) at the 1-position. The introduction ratio of imidazolium salts into P1 was estimated to be from 93 to 100 mol % from ¹H NMR anal. The glass transition temperatures (T_gs) of [PImn]Cls were determined by differential scanning calorimetry (DSC). Of all the samples. [Plm5]Cl and [Plm6]|Cl had the lowest T_g of 14°C which is 12-15 K lower than the T_g of polysiloxane homopolymer having quaternized imidazolium salts without polydimethylsiloxane units. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem