Author: Jessica.F

Intracerebroventricular Administration of Metformin Inhibits Ghrelin-Induced Hypothalamic AMP-Kinase Signalling and Food Intake was written by Stevanovic, Darko;Janjetovic, Kristina;Misirkic, Maja;Vucicevic, Ljubica;Sumarac-Dumanovic, Mirjana;Micic, Dragan;Starcevic, Vesna;Trajkovic, Vladimir. And the article was included in Neuroendocrinology in 2012.Computed Properties of C4H5N3O This article mentions the following:

Background/Aims: The antihyperglycemic drug metformin reduces food consumption through mechanisms that are not fully elucidated. The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signaling pathways induced by the orexigenic peptide ghrelin. Methods: Rats were injected intracerebroventricularly with ghrelin (5 μg), metformin (50, 100 or 200 μg), 5-amino-imidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR, 25 μg) and L-leucine (1 μg) in different combinations. Food intake was monitored during the next 4 h. Hypothalamic activation of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), regulatory-associated protein of mTOR (Raptor), mammalian target of rapamycin (mTOR) and p70 S6 kinase 1 (S6K) after 1 h of treatment was analyzed by immunoblotting. Results: Metformin suppressed the increase in food consumption induced by intracerebroventricular ghrelin in a dose-dependent manner. Ghrelin increased phosphorylation of hypothalamic AMPK and its targets ACC and Raptor, which was associated with the reduced phosphorylation of mTOR. The mTOR substrate, S6K, was activated by intracerebroventricular ghrelin despite the inhibition of mTOR. Metformin treatment blocked ghrelin-induced activation of hypothalamic AMPK/ACC/Raptor and restored mTOR activity without affecting S6K phosphorylation. Metformin also reduced food consumption induced by the AMPK activator AICAR while the ghrelin-triggered food intake was inhibited by the mTOR activator L-leucine. Conclusion: Metformin could reduce food intake by preventing ghrelin-induced AMPK signaling and mTOR inhibition in the hypothalamus. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Computed Properties of C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Computed Properties of C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Gelling Ability of Some Diimidazolium Salts: Effect of Isomeric Substitution of the Cation and Anion was written by D’Anna, Francesca;Vitale, Paola;Ferrante, Francesco;Marullo, Salvatore;Noto, Renato. And the article was included in ChemPlusChem in 2013.Electric Literature of C11H20N2 This article mentions the following:

The gelling ability of some geminal imidazolium salts was studied both in organic solvents and in water solution Organic salts differing either in the cation or anion structure were taken into account. In particular, the effects on the gel-phase formation of isomeric substitution on the cation or anion and of the use of mono- or dianions were evaluated. As far as the cation structure is concerned, isomeric cations, such as 3,3′-di-n-octyl-1,1′-(1,4-phenylenedimethylene)diimidazolium and 3,3′-di-n-octyl-1,1′-(1,3-phenylenedimethylene)diimidazolium, were used. However, in addition to the bromide anion, isomeric dianions, such as the 1,5- and 2,6-naphthalenedisulfonate anions, were also examined After preliminary gelation tests, different factors affecting the obtained gel phases, such as the nature of the solvent, organogelator concentrations, and action of external stimuli, were analyzed. The gel-phase formation was also studied as a function of time, by using resonance light scattering measurements. Gel morphologies were analyzed by SEM. To further support the understanding of the different behavior shown by the isomeric cations, some representative ion pairs were analyzed by DFT-based studies. The collected data underline the significant role played by isomeric substitution of both cation and anion structures in determining the gelling capability of the studied salts, as well as the properties of the gel phases. Finally, DFT studies were helpful in the identification of the structural features affecting the self-assembly. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform was written by Newby, James A.;Blaylock, D. Wayne;Witt, Paul M.;Pastre, Julio C.;Zacharova, Marija K.;Ley, Steven V.;Browne, Duncan L.. And the article was included in Organic Process Research & Development in 2014.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkylimidazolium Based Ionic Liquids: Impact of Cation Symmetry on Their Nanoscale Structural Organization was written by Rocha, Marisa A. A.;Neves, Catarina M. S. S.;Freire, Mara G.;Russina, Olga;Triolo, Alessandro;Coutinho, Joao A. P.;Santos, Luis M. N. B. F.. And the article was included in Journal of Physical Chemistry B in 2013.Synthetic Route of C18H31F6N3O4S2 This article mentions the following:

Aiming at evaluating the impact of the cation symmetry on the nanostructuration of ionic liquids (ILs), in this work, densities and viscosities as a function of temperature and small-wide angle X-ray scattering (SWAXS) patterns at ambient conditions were determined and analyzed for 1-alkyl-3-methylimidazolium bis-(trifluoromethylsulfonyl)-imide (asym.) and 1,3-dialkylimidazolium bis-(trifluoromethylsulfonyl)-imide (sym.) series of ionic liquids The sym. IL series, [C_N/2C_N/2i.m.]-[NTf₂], presents lower viscosities than the asym. [C_N-1C₁i.m.]-[NTf₂] counterparts. For ionic liquids from [C₁C₁i.m.]-[NTf₂] to [C₆C₆i.m.]-[NTf₂], an odd-even effect in the viscosity along the cation alkyl side chain length was observed, in contrast with a linear increase found for the ones ranging between [C₆C₆i.m.]-[NTf₂] and [C₁₀C₁₀i.m.]-[NTf₂]. The anal. of the viscosity data along the alkyl side chain length reveals a trend shift that occurs at [C₆C₁i.m.]-[NTf₂] for the asym. series and at [C₆C₆i.m.]-[NTf₂] for the sym. series. These results are further supported by SWAXS measurements at ambient conditions. The gathered data indicate that both asym. and sym. members are characterized by the occurrence of a distinct degree of mesoscopic structural organization above a given threshold in the side alkyl chain length, regardless the cation symmetry. The data also highlight a difference in the alkyl chain dependence of the mesoscopic cluster sizes for sym. and asym. cations, reflecting a different degree of interdigitation of the aliphatic tails in the two families. The trend shift found in this work is related to the structural segregation in the liquid after a critical alkyl length size (CALS) is attained and has particular relevance in the cation structural isomerism with higher symmetry. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Synthetic Route of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic-liquid-modified CMK-3 as a support for the immobilization of molybdate ions (MoO₄^2-): Heterogeneous nanocatalyst for selective oxidation of sulfides and benzylic alcohols was written by Hosseini-Eshbala, Fereshteh;Sedrpoushan, Alireza;Breit, Bernhard;Mohanazadeh, Farajollah;Veisi, Hojat. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Computed Properties of C11H20N2 This article mentions the following:

A nanometric carbon CMK-3 modified with octylimidazolium ionic liquid (OctIm) and MoO₄^2- as a new hybrid catalyst was synthesized. The study is the first to report a successful immobilization of MoO₄^2- on the CMK-3/OctIm as a hybrid nanocatalyst. A variety of anal. methods were utilized to determine the properties of the structure and morphol. of the synthesized nanocatalyst [CMK-3/OctIm/ MoO₄^2-]. The anal. techniques were transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma (ICP), X-ray diffraction (XRD), N₂ isotherms (BET), IR spectroscopy and thermogravimetric anal. (TGA). CMK-3/OctIm/ MoO₄^2- hybrid catalyst demonstrated a considerable catalytic activity. It is a recyclable nanocatalyst that is utilized to chemoselectively oxidize different types of sulfides RSR¹ (R = Me, Ph, prop-2-en-1-yl, etc.; R¹ = Me, Ph, cyanomethyl, etc.) and thianthrene to the corresponding sulfoxides RS(O)R¹ and thianthrene,5,10-dioxide and benzylic alcs. R²CH₂OH (R² = Ph, 3,4,5-trimethoxyphenyl, 3-chlorophenyl, etc.) to aldehydes R²CHO using the green oxidant, hydrogen peroxide (H₂O₂) in high-yields. With a little leaching and variation in activity, it is possible to recover and reuse the catalyst frequently. A combination of molybdate anion and the CMK-3 order mesoporous carbon resulted in an improvement in the performance of catalysis and ease of separation for the reaction procedure. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis, and docking studies of telmisartan analogs for the treatment of metabolic syndrome was written by Mizuno, Cassia S.;Chittiboyina, Amar G.;Patny, Akshay;Kurtz, Theodore W.;Pershadsingh, Harrihar A.;Speth, Robert C.;Karamyan, Vardan T.;Avery, Mitchell A.. And the article was included in Medicinal Chemistry Research in 2009.Recommanded Product: 4887-83-6 This article mentions the following:

In our early studies, telmisartan was found to be a moderate peroxisome proliferator-activated receptor (PPAR) gamma activator in the human PPARγ-GAL-4 cell-based transactivation assay. Thus, novel analogs of telmisartan were designed, synthesized, and evaluated in the AT₁ receptor binding assay and PPAR gamma transactivation assay. A total of 11 compounds were designed based on docking in both AT₁ receptor model and PPAR gamma active pocket and synthesized. Introduction of an addnl. acidic group at the para position of the distal Ph ring of telmisartan decreased affinity towards AT₁ receptor and PPARγ activity. In the present study, the mol. with best results was I, with weak PPARγ activity (8% of maximum PPARγ activation achieved by full agonist rosiglitazone at 10 μM) and good binding affinity (K_i = 650 ± 139 nM) towards the AT₁ receptor. Docking of I into AT₁ receptor model and PPAR gamma showed very similar interactions with the receptors as AT₁ antagonist telmisartan and PPAR gamma agonist rosiglitazone. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Recommanded Product: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Microstructure and Tribological Properties of Lamellar Liquid Crystals Formed by Ionic Liquids as Cosurfactants was written by Chen, Liping;Ge, Lingling;Fan, Lei;Guo, Rong. And the article was included in Langmuir in 2019.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Lamellar liquid crystals (LLCs) have been shown to have lubrication properties in many documents due to their bilayer structure. Ionic liquids are often used as additive or surfactant in LLCs. However, ionic liquids used as cosurfactants, which lead to a transition from the hexagonal liquid crystals to LLCs, are relatively rare. Herein, the microstructure of Triton X-100/C_nmimNTf₂/H₂O LLCs formed by using 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ionic liquid (C_nmimNTf₂, n = 8, 12, 16) as cosurfactant has been determined by polarized light microscopy, small angle X-ray scattering, and ²H NMR technique, and their rheol. and tribol. properties were investigated. These LLCs show good friction-reducing and antiwear performances. The correlation between the microstructure of the LLCs and their lubricating mechanism is established. The increase of the concentration of C_nmimNTf₂ and the length of alkyl chain in the LLCs can lead to an obvious reduction in friction coefficients and wear volumes, which are attributed to the higher order of amphiphilic mols., the thickness of the amphiphilic bilayer, and the smaller cross-sectional area of the polar head group at the hydrophilic and hydrophobic interfaces. The protective film formed by the phys. adsorption of ionic liquid LLCs on the surface of friction disk pair and the tribochem. reaction has effectively promoted the lubrication effect. The good lubricating property and antiwear capability indicate their promising and potential applications in water lubrication and biol. lubrication. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of Alkyl Chain Length on Derived Thermodynamic Properties of 1-Alkyl-3-methylimidizolium Chloride Ionic Liquids and Their Mixtures with Ethanol was written by McCorkill, Mary E.;Dickmann, James S.;Kiran, Erdogan. And the article was included in Industrial & Engineering Chemistry Research in 2019.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Densities of the ionic liquids [C₂C₁i.m.]Cl, [C₃C₁i.m.]Cl, [C₄C₁i.m.]Cl, and [C₆C₁i.m.]Cl and their mixtures with EtOH were determined up to 40 MPa and 398 K. D. was modeled as a function of temperature, pressure, and composition using the Sanchez-Lacombe equation of state. Using the model, derived thermodn. properties, isothermal compressibility, isobaric expansivity, and internal pressure, were calculated This allowed for the estimation of the Hildebrand solubility parameters of these ionic liquids (ILs). Internal pressure was found to go through a maximum at low concentrations of ionic liquid in the case of [C₃C₁i.m.]Cl, [C₄C₁i.m.]Cl, and [C₆C₁i.m.]Cl. These observations were interpreted in terms of a significant effect of the alkyl chain length on the interactions between the IL and the cosolvent, EtOH. It is speculated that this is in part due to possible clustering between (Cl^–) and EtOH. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrogen bonds of the imidazolium rings of ionic liquids with DMSO studied by NMR, soft X-ray spectroscopy, and SANS was written by Takamuku, Toshiyuki;Tokuda, Takumi;Uchida, Takahiro;Sonoda, Kazuya;Marekha, Bogdan A.;Idrissi, Abdenacer;Takahashi, Osamu;Horikawa, Yuka;Matsumura, Junya;Tokushima, Takashi;Sakurai, Hiroyuki;Kawano, Masahiro;Sadakane, Koichiro;Iwase, Hiroki. And the article was included in Physical Chemistry Chemical Physics in 2018.Category: imidazoles-derivatives This article mentions the following:

The hydrogen bonds of the imidazolium-ring H atoms of ionic liquids (ILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amides ([C_nmim][TFSA], n = 2 to 12 where n represents the alkyl chain length), with the O atom of DMSO (DMSO) have been elucidated using ¹H, ¹³C, and ¹⁵N NMR spectroscopy and soft X-ray absorption and emission spectroscopy (XAS and XES). D. functional theory (DFT) calculations have been performed on an isolated DMSO mol. and two cluster models of [C_nmim]⁺-DMSO by hydrogen bonding to interpret the XES spectra for the [C_nmim][TFSA]-DMSO solutions The ¹H and ¹³C NMR chem. shifts of the imidazolium ring showed that deshielding of the ring H and C atoms is moderate as the DMSO mole fraction x_DMSO increases to ∼0.8; however, it becomes more significant with further increase of x_DMSO. This finding suggests that the hydrogen bonds of the three ring H atoms with the DMSO O atoms are saturated in solutions with x_DMSO increased to ∼0.8. The ¹H and ¹³C chem. shifts of the alkyl chains revealed that the electron densities of the chain H and C atoms gradually decrease with increasing x_DMSO, except for the N¹-bound carbon atom C⁷ of the chain. The ¹⁵N NMR chem. shifts showed that the imidazolium-ring N¹ atom which is bound to the alkyl chain is shielded with increasing x_DMSO in the range from 0 to 0.8 and is then deshielded with further increase of x_DMSO. In contrast, the imidazolium ring N³ atom is simply deshielded with increasing x_DMSO. Thus, the electron densities of the alkyl chain may be condensed at the C⁷ and N¹ atoms of [C_nmim]⁺ by the hydrogen bonding of the ring H atoms with DMSO. The hydrogen bonding of DMSO with the ring results in low-energy shifts of the XES peaks of the O K-edge of DMSO. Small-angle neutron scattering experiments showed that [C_nmim][TFSA] and DMSO are homogeneously mixed with each other on the mesoscopic scale. This results from the strong hydrogen bonds of DMSO with the imidazolium-ring H atoms. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Category: imidazoles-derivatives).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CO₂/N₂ Triggered Switchable Surfactants with Imidazole Group was written by Chai, Mingfeng;Zheng, Zhibo;Bao, Lei;Qiao, Weihong. And the article was included in Journal of Surfactants and Detergents in 2014.COA of Formula: C11H20N2 This article mentions the following:

In order to overcome the hydrolysis of 2-alkyl-1-hydroxyethyl imidazoline and its unsatisfactory emulsification-demulsification switchability to water-alkane, the long-chain N-alkylimidazole compounds were synthesized by n-octyl bromide, n-decyl bromide, n-dodecyl bromide, n-tetradecyl bromide and n-hexadecyl bromide with imidazole, resp. and characterized by MS, ¹H NMR and FTIR. The long-chain N-alkylimidazole compounds can be reversibly transformed into charged surfactants by exposure to CO₂. Surface tension values indicated that N-alkylimidazolium bicarbonates had excellent surface activity compared with corresponding conventional surfactants with a lower γ_CMC. The surface behaviors of the five surfactants can be illustrated by A_min. Five conductivity cycles by bubbling CO₂ and N₂ alternately indicated that these surfactants could be switched by CO₂ reversibly and repeatedly. Emulsions were repeatedly stabilized for five cycles by N-alkylimidazolium bicarbonate and broken by bubbling N₂ through the solutions to reverses the reaction, releasing CO₂. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem