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Yasukata, Tatsuro et al. published their research in Heterocycles in 2021 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 1632-83-3

Efficient synthesis of acrylates bearing an aryl or heteroaryl moiety: one-pot method from aromatics and heteroaromatics using formylation and the Horner-Wadsworth-Emmons reaction was written by Yasukata, Tatsuro;Matsuura, Takaharu. And the article was included in Heterocycles in 2021.HPLC of Formula: 1632-83-3 This article mentions the following:

Acrylates bearing an aryl or heteroaryl moiety were efficiently prepared by a one-pot process employing a sequence of lithiation, formylation and the Horner-Wadsworth-Emmons reaction starting from aromatic and heteroaromatic compounds The method was efficiently introduced an acrylate moiety into aromatic and heteroaromatic compounds In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ramalingam, Kondareddiar et al. published their research in Tetrahedron in 1995 | CAS: 22813-32-7

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C5H5N3O4

Synthesis of nitroimidazole substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioximes (propylene amine oximes, PnAOs): ligands for technetium-99m complexes with potential for imaging hypoxic tissue was written by Ramalingam, Kondareddiar;Raju, Natarajan;Nanjappan, Palaniappa;Nowotnik, David P.. And the article was included in Tetrahedron in 1995.COA of Formula: C5H5N3O4 This article mentions the following:

A series of 2-substituted-1,3-diaminopropanes have been synthesized as precursors to nitroimidazole-substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime (propylene amine oxime, PnAO) ligands. 3-Chloro-3-methyl-1-(2- or 4-nitro-1H-imidazol-1-yl)-2-nitrosobutanes required for the syntheses of nitroimidazole substituted PnAO ligands were prepared from the corresponding dimethylallylnitroimidazoles by the addition of nitrosyl chloride. A number of nitroimidazole derivatized PnAO ligands possessing potential for either electrostatic, hydrophobic, or hydrophilic interactions were synthesized as precursors to technetium-99m complexes under investigation as potential imaging agents of hypoxia. Derivatives of PnAO, substituted at carbon one, were prepared using the 3-chloro-3-methyl-1-(2- or 4-nitro-1H-imidazol-1-yl)-2-nitrosobutanes. Three PnAOs derivatized at the central carbon atom were prepared using 3-bromo-3-methylbutan-2-one. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7COA of Formula: C5H5N3O4).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jelinkova, Kristyna et al. published their research in New Journal of Chemistry in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 1632-83-3

Binding study on 1-adamantylalkyl(benz)imidazolium salts to cyclodextrins and cucurbit[n]urils was written by Jelinkova, Kristyna;Kovacevic, Jelica;Wrzecionkova, Eva;Pruckova, Zdenka;Rouchal, Michal;Dastychova, Lenka;Vicha, Robert. And the article was included in New Journal of Chemistry in 2020.Related Products of 1632-83-3 This article mentions the following:

Multitopic guests are used as key components of mol. triggers, switchers, sensors, or reactors in recent supramol. chem. studies. The increasing complexity of these compounds correlates with the need for versatile, synthetically available binding motifs (building blocks) with tuneable supramol. properties. The utilization of a favored 1-adamantylmethyl moiety in ammonium, imidazolium and pyridinium salts is sometimes restricted by synthetic difficulties most likely related to the adamantane cage bulkiness. Therefore, we prepared a series of new adamantylated (benz)imidazolium salts with longer flexible linkers between the adamantane cage and cationic moiety. We tested the supramol. properties of these binding motifs towards the natural cyclodextrins α-CD, β-CD and γ-CD and cucurbit[n]urils (n = 7, 8) using NMR, mass spectrometry and titration calorimetry. All tested guests formed 1 : 1 complexes with the abovementioned hosts, retaining binding strengths, selectivity, and complex geometries in comparison to the parent methylene-linked homologues. We did not confirm our original concern that longer linkers would neg. affect the binding strength towards CBns due to the reduction in the ion-dipole interaction contribution. Therefore, we believe that adamantylalkyl imidazolium binding motifs can be used for multitopic supramol. guest construction. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shimomura, Takuya et al. published their research in Physical Chemistry Chemical Physics in 2013 | CAS: 404001-48-5

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

SANS, ATR-IR, and 1D- and 2D-NMR studies of mixing states of imidazolium-based ionic liquid and aryl solvents was written by Shimomura, Takuya;Inoue, Saori;Kadohata, Shoya;Umecky, Tatsuya;Takamuku, Toshiyuki. And the article was included in Physical Chemistry Chemical Physics in 2013.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The mixing states of imidazolium-based ionic liquid, 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide (C₁₂mim⁺TFSA^–), and two aryl solvents toluene and α,α,α-trifluorotoluene (TFT) were clarified on both meso- and microscopic scales using small-angle neutron scattering (SANS) and ATR-IR techniques. To elucidate the interactions between C₁₂mim⁺TFSA^– and aryl solvent mols. from the change in the electron densities of C₁₂mim⁺ and TFSA^–, 1-dimensional-NMR measurements for ¹H and ¹³C atoms were conducted on C₁₂mim⁺TFSA^–-aryl solvent solutions as a function of the aryl solvent mole fraction. The interactions between the dodecyl chain of C₁₂mim⁺ and aryl solvent mols. were observed using 2-dimensional-NMR techniques of ¹H{¹H} ROESY and ¹⁹F{¹H} HOESY. These results were compared with those of benzene solutions previously studied. The SANS measurements showed that toluene is heterogeneously mixed with C₁₂mim⁺TFSA^– as well as benzene. However, the heterogeneity of the toluene solutions is slightly lower than that of the benzene solutions In contrast, TFT is homogeneously mixed with the ionic liquid at least on the present SANS scale. The substituent effects of the three aryl solvent mols. of benzene, toluene, and TFT on the mixing states of the solutions are discussed in terms of the cation-π interaction between the imidazolium and Ph rings and the interaction between the dodecyl group and aryl solvent mols. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Grigor’ev, V. P. et al. published their research in Protection of Metals (Translation of Zashchita Metallov) in 2002 | CAS: 24134-26-7

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C9H9N3

Dependence of the protective properties of mixtures based on several reaction series on the number and concentrations of the components was written by Grigor’ev, V. P.;Shpan’ko, S. P.;Nassar, A. F.;Anisimova, V. A.. And the article was included in Protection of Metals (Translation of Zashchita Metallov) in 2002.Electric Literature of C9H9N3 This article mentions the following:

Mixtures based on azomethine, imidazobenzoimidazole, and pyrimidobenzoimidazole derivatives were tested as inhibitors of iron corrosion in 1 M H₂SO₄ in the presence of 0.25 mol/l NaCl. The number and concentrations of their components were varied with the aim of studying their influence on the protection effects of the mixtures The resulting exptl. dependences, of the protective effectiveness on the number and concentration of the components, as well as the polar properties of substituents in their mols., can be interpreted in terms of the linear Gibbs energy relation (LGER). This conclusion is valid over a wide range of medium temperatures (20-60°C), provided the volume concentrations of compounds in each reaction series are kept constant In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Electric Literature of C9H9N3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yu, Xuan et al. published their research in RSC Advances in 2018 | CAS: 85692-37-1

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C6H8N2O

A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(II)-catalyzed enantioselective Michael addition was written by Yu, Xuan;Bai, Hui;Wang, Dong;Qin, Zhaohai;Li, Jia-Qi;Fu, Bin. And the article was included in RSC Advances in 2018.Computed Properties of C6H8N2O This article mentions the following:

A Ni(II)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF₂H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provided a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF₂H group. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Taheri, Peyman et al. published their research in npj Materials Degradation in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 1-Methylbenzimidazole

On the importance of time-resolved electrochemical evaluation in corrosion inhibitor-screening studies was written by Taheri, Peyman;Milosev, Ingrid;Meeusen, Mats;Kapun, Barbara;White, Paul;Kokalj, Anton;Mol, Arjan. And the article was included in npj Materials Degradation in 2020.Name: 1-Methylbenzimidazole This article mentions the following:

Efficiency of corrosion inhibitors in aqueous solutions depends on several interfacial parameters, which may vary over time. Therefore, reliable electrochem. techniques are demanded for screening the efficiency of corrosion inhibitors and monitoring their performance over time. Here, we evaluate corrosion inhibition efficiency of imidazole-based compounds on bare Cu surfaces and highlight the importance of electrochem. evaluation of the inhibitor over time, characterized by linear polarization resistance techniques as a reliable, instantaneous and non-invasive method for assessing intrinsic inhibitor performance in lab screening studies. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Name: 1-Methylbenzimidazole).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Megger, Dominik A. et al. published their research in Journal of Inorganic Biochemistry in 2011 | CAS: 83741-35-9

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 4-Bromo-1H-benzoimidazole

Silver(I)-mediated Hoogsteen-type base pairs was written by Megger, Dominik A.;Fonseca Guerra, Celia;Bickelhaupt, F. Matthias;Mueller, Jens. And the article was included in Journal of Inorganic Biochemistry in 2011.Recommanded Product: 4-Bromo-1H-benzoimidazole This article mentions the following:

Metal-mediated Hoogsteen-type base pairs are useful for the construction of DNA duplexes containing contiguous stretches of metal ions along the helical axis. To fine-tune the stability of such base pairs and the selectivity toward different metal ions, the availability of a selection of artificial nucleobases is highly desirable. In this study, we follow a theor. approach utilizing dispersion-corrected d. functional methods to evaluate a variety of artificial nucleobases as candidates for metal-mediated Hoogsteen-type base pairs. We focus on silver(I)-mediated Hoogsteen- and reverse Hoogsteen-type base pairs formed between 1-deaza- and 1,3-dideazapurine-derived nucleobases, resp., and cytosine. Apart from two coordinative bonds, these base pairs are stabilized by a hydrogen bond. We elucidate the impact of different substituents at the C6 position and the presence or absence of an endocyclic N3 nitrogen atom on the overall stability of a base pair and concomitantly on the strength of the hydrogen and coordinative bonds. All artificial base pairs investigated in this study are less stable than the exptl. established benchmark base pair C-Ag⁺-G. The base pair formed from 1,3-dideaza-6-methoxypurine is isoenergetic to the exptl. observed C-Ag⁺-C base pair. This makes 1,3-dideaza-6-methoxypurine a promising candidate for the use as an artificial nucleobase in DNA. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Recommanded Product: 4-Bromo-1H-benzoimidazole).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ryabukhin, Dmitry S. et al. published their research in Beilstein Journal of Organic Chemistry in 2019 | CAS: 3012-80-4

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 3012-80-4

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkyl-substituted benzimidazoles with arenes in the superacid CF3SO3H. NMR and DFT studies of dicationic electrophilic species was written by Ryabukhin, Dmitry S.;Turdakov, Alexey N.;Soldatova, Natalia S.;Kompanets, Mikhail O.;Ivanov, Alexander Yu.;Boyarskaya, Irina A.;Vasilyev, Aleksander V.. And the article was included in Beilstein Journal of Organic Chemistry in 2019.Application of 3012-80-4 This article mentions the following:

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Bronsted superacid TfOH resulted in the formation of the corresponding Friedel-Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles, in yields up to 90%. The reaction intermediates, protonated species derived from starting benzimidazoles in TfOH, were thoroughly studied by means of NMR and DFT calculations; and plausible reaction mechanisms were discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application of 3012-80-4).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lundberg, Lindsay et al. published their research in Antiviral Research in 2018 | CAS: 145040-37-5

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 145040-37-5

Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses was written by Lundberg, Lindsay;Brahms, Ashwini;Hooper, Idris;Carey, Brian;Lin, Shih-Chao;Dahal, Bibha;Narayanan, Aarthi;Kehn-Hall, Kylene. And the article was included in Antiviral Research in 2018.Recommanded Product: 145040-37-5 This article mentions the following:

The New World alphaviruses -Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, and WEEV resp.) – cause a febrile disease that is often lethal in equines and children and leads to long-term neurol. sequelae in survivors. Endemic to the Americas, epizootic outbreaks of the three viruses occur sporadically in the continental United States. All three viruses aerosolize readily, replicate to high titers in cell culture, and have low infectious doses. Addnl., there are no FDA-approved vaccines or therapeutics for human use. To address the therapeutic gap, a high throughput assay utilizing a luciferase reporter virus, TC83-luc, was performed to screen a library of com. available, FDA-approved drugs for antiviral activity. From a group of twenty compounds found to significantly decrease luminescence, the carcinoma therapeutic sorafenib inhibited replication of VEEV-TC83 and TrD in vitro. Addnl., sorafenib inhibited replication of EEEV and two Old World alphaviruses, Sindbis virus and chikungunya virus, at 8 and 16h post-infection. Sorafenib caused no toxicity in Vero cells, and coupled with a low EC₅₀ value, yielded a selectivity index of >19. Mechanism of actions studies suggest that sorafenib inhibited viral translation through dephosphorylation of several key proteins, including eIF4E and p70S6K, leading to a reduction in viral protein production and overall viral replication. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 145040-37-5).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem