Author: Jessica.F

Protic ionic liquids: A highly efficient catalyst for synthesis of cyclic carbonate from carbon dioxide and epoxides was written by Xiao, Linfei;Su, Dan;Yue, Chengtao;Wu, Wei. And the article was included in Journal of CO2 Utilization in 2014.Formula: C4H7ClN2 This article mentions the following:

An efficient, inexpensive, easily prepared and sustainable catalytic system of protic ionic liquids was developed for cycloaddition of CO2 and epoxides to produce cyclic carbonates without using any co-catalyst and organic solvent. The effects of the acidity and structure of protic ionic liquid on the catalytic performance were investigated and the various reaction conditions were optimized. Notably, this catalyst was used for five times at least without appreciable loss of catalytic activity and applied for various epoxide for synthesis of corresponding cyclic carbonate in high selectivity and yield. Addnl., a mechanism for the synergistic effects of cation and anion in protic ionic liquids was also proposed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvent-free synthesis of tris(4-hydroxybutyl acrylate) phosphate in the presence of 1-methylimidazole was written by Ilia, Gheorghe;Macarie, Lavinia;Plesu, Nicoleta;Iliescu, Smaranda;Popa, Adriana. And the article was included in Journal of the Iranian Chemical Society in 2018.HPLC of Formula: 35487-17-3 This article mentions the following:

In this paper, we present the synthesis of tris(4-hydroxybutyl acrylate) phosphate using 1-methylimidazole as acid scavenger for hydrochloric acid byproduct, when an ionic liquid is formed. The synthesis was performed in the absence of any organic solvent. The yield is 83% for ester. The phosphate was characterized by ¹H-³¹P NMR and FTIR. The obtained phosphate is appropriate monomer for UV curing in the presence of photoinitiator. The obtained polymer was characterized by thermal anal. and LOI. The results showed good thermal stability and flame retardancy of UV-cured polymer. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids was written by Stagel, Kristof;Szpecht, Andrea;Zielinski, Dawid;Smiglak, Marcin;Schnuerch, Michael;Bica-Schroeder, Katharina. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

A novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf₂^–) anion. The simple yet fast two-step synthetic route, which involved the formation of different alkyl bistriflimides (RNTf₂), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R) length and the broad range of the applicable nucleophiles offer considerable flexibility to the synthetic protocol. The quaternization could be performed under solvent-free conditions; moreover, the homogeneous nature of these reactions allowed the application of modern continuous-flow technologies. Given these advantages, the methodol. could afford not just a fast and efficient alternative for the conventional synthesis of such compounds with reduced waste water production but their negligible halide content might provided a significantly broader application range of the IL products, especially for the field of materials science. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors was written by Gandini, Annachiara;Bartolini, Manuela;Tedesco, Daniele;Martinez-Gonzalez, Loreto;Roca, Carlos;Campillo, Nuria E.;Zaldivar-Diez, Josefa;Perez, Concepcion;Zuccheri, Giampaolo;Miti, Andrea;Feoli, Alessandra;Castellano, Sabrina;Petralla, Sabrina;Monti, Barbara;Rossi, Martina;Moda, Fabio;Legname, Giuseppe;Martinez, Ana;Bolognesi, Maria Laura. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 3012-80-4 This article mentions the following:

Several findings propose the altered tau protein network as an important target for Alzheimer’s disease (AD). Particularly, two points of pharmacol. intervention can be envisaged: inhibition of phosphorylating tau kinase GSK-3β and tau aggregation process. On the basis of this consideration and on the authors’ interest in multitarget paradigms in AD, the authors report on the discovery of 2,4-thiazolidinedione derivatives endowed with such a profile. 28 and 30 displayed micromolar IC₅₀ values toward GSK-3β, together with the capacity of inhibiting AcPHF6 aggregation of 60% and 80% at 10 μM, resp. In addition, they showed PAMPA-BBB permeability, together with a suitable cellular safety profile. 30 also displayed inhibition of both K18 and full-length tau aggregations. Finally, both compounds were able to improve cell viability in an okadaic acid-induced neurodegeneration cell model. To the best of the authors’ knowledge, 28 and 30 are the first balanced, nontoxic, dual-acting compounds hitting tau cascade at two different hubs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structural-functional evaluation of ionic liquid libraries for the design of co-solvents in lipase-catalysed reactions was written by Rodrigues, Joao V.;Ruivo, Diana;Rodriguez, Ana;Deive, Francisco J.;Esperanca, Jose M. S. S.;Marrucho, Isabel M.;Gomes, Claudio M.;Rebelo, Luis Paulo N.. And the article was included in Green Chemistry in 2014.Related Products of 79917-89-8 This article mentions the following:

Using ionic liquids as co-solvents may improve reaction media in enzyme-based biotechnol. processes. To establish new conditions, large libraries need to be screened for bio-compatibility and protein stabilization. Using a lipase model, we herein describe a combination of methods leading to an expedited evaluation of 61 different solvent compositions In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Related Products of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Related Products of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential was written by Adams, G. E.;Stratford, I. J.;Wallace, R. G.;Wardman, P.;Watts, M. E.. And the article was included in JNCI, Journal of the National Cancer Institute in 1980.Synthetic Route of C5H5N3O4 This article mentions the following:

Fifteen nitroarom. and nitroheterocyclic compounds that can act as radiosensitizers were tested for their cytotoxicity toward hypoxic Chinese hamster V79 cells in vitro. The cytotoxicity increased markedly as the electron affinity, measured as a one-electron reduction potential, increased. Nonnitro compounds of similar electron affinities (such as quinones) that also act as radiosensitizers did not exhibit this specific toxicity toward hypoxic cells. The implications of the presence of the nitro group as a prerequisite for the hypoxic cell toxicity are discussed, and the mechanism of the cytotoxicity was compared with that of hypoxic cell radiosensitization. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Synthetic Route of C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitration of 2,3-dihydroimidazo[1,2-a]benzimidazole and its N⁹-substituted derivatives was written by Sochnev, Vadim S.;Kuz’menko, Tatyana A.;Morkovnik, Anatolii S.;Divaeva, Lyudmila N.;Podobina, Anastasia S.;Zubenko, Alexander A.;Chepurnoy, Pavel B.;Borodkin, Gennadii S.;Klimenko, Alexander I.. And the article was included in Mendeleev Communications in 2021.Electric Literature of C9H9N3 This article mentions the following:

7-Nitro-2,3-dihydroimidazo[1,2-a]benzimidazole and its N⁹-substituted derivatives could be conveniently synthesized by nitration of the corresponding tricyclic precursors with a nitrating mixture or with the HNO₃/CF₃COOH system. This reaction occurred fairly smoothly and with good regioselectivity. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Electric Literature of C9H9N3).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C9H9N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and characterization of nano-copper ferrite as a magnetically separable catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles under solvent-free condition was written by Nemati, Firouzeh;Elhampour, Ali;Natanzi, Mahshid Bagheri. And the article was included in Inorganic and Nano-Metal Chemistry in 2017.HPLC of Formula: 5496-35-5 This article mentions the following:

Synthesis and characterization of nano-copper ferrite as a recoverable, eco-friendly, inexpensive and readily available catalyst for efficient, simple and green synthesis of multi-substituted imidazoles I [Ar¹ = H, Ph, 2-thiophene, etc.; Ar² = Ph, 4-MeC₆H₄, 4-ClC₆H₄] was reported. Short reaction times, high yields, easy workup and mild condition were the advantages of this protocol. The catalyst could be reused without evident loss of the catalytic activity. Characterization of the catalyst was performed fully by Fourier transform IR spectra, X-ray diffraction, FESEM, electron dispersive X-ray and vibration sampling magnetometer anal. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and crystallization of 3-methyl-1-propyl-1,3-dihydro-1H-imidazol-2-ylidene)silver(I) chlorido(5,10,15,20-tetraphenylporphinato)cadmate(II) was written by Bruekers, J. P. J.;Elemans, J. A. A. W.;Nolte, R. J. M.;Tinnemans, P.. And the article was included in IUCrData in 2022.SDS of cas: 79917-89-8 This article mentions the following:

The structure of the title salt, [Ag(C₇H₁₂N₂)₂][CdCl(C₄₄H₂₈N₄)], at 150 K has triclinic symmetry. One of the Ph rings bonded to the porphyrin mol. and the Pr groups of both ylidene mols. coordinating to silver are disordered over two positions. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8SDS of cas: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of α-Difluoromethyl Aryl Ketones through a Photoredox Difluoromethylation of Enol Silanes was written by Selmi-Higashi, Elias;Zhang, Jinlei;Cambeiro, Xacobe C.;Arseniyadis, Stellios. And the article was included in Organic Letters in 2021.COA of Formula: C6H8N2O This article mentions the following:

An efficient and highly straightforward access to α-difluoromethylated ketones through a visible light-mediated difluoromethylation of readily available enol silanes was reported. The method, which takes advantage of the polyvalence of Hu’s reagent, N-tosyl-S-difluoromethyl-S-phenylsulfoximine, used here as a CHF₂ radical precursor under catalytic photoredox conditions, was practical, scalable and provided the corresponding α-CHF₂ ketones in good to excellent yields. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem