Author: Jessica.F

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Formula: C4H4N2O.

Li, Jun;Weng, Yingwei;Shen, Can;Luo, Jiao;Yu, Donghong;Cao, Zhong research published 《 Sensitive fluorescence and visual detection of organophosphorus pesticides with a Ru(bpy)₃²⁺-ZIF-90-MnO₂ sensing platform》, the research content is summarized as follows. Fluorescence sensing organophosphorus pesticides (OPs) is of great importance for both food safety and global environment; however, the reported fluorescent probes are usually directly exposed to the external environment, resulting in premature leakage or photobleaching and thus limiting their photostability and assay sensitivity. In this work, a fluorescent sensing platform consisting of a novel luminescent metal-organic framework (Ru(bpy)₃²⁺-ZIF-90) and manganese dioxide nanosheets (MnO₂ NSs) was prepared for sensing OPs. Due to the protection and improvement in the fluorescence of Ru(bpy)₃²⁺ by ZIF-90, the Ru(bpy)₃²⁺-ZIF-90 probe displayed remarkable photostability and high stability in water. By virtue of the high stability of Ru(bpy)₃²⁺-ZIF-90, as well as the outstanding fluorescence quenching and notable recognition ability of the MnO₂ NSs, this sensing platform provided excellent detection capability for parathion-Me, with a wide concentration range of 0.050-60 ng mL^-1 and a low detection limit of 0.037 ng mL^-1. Addnl., the system exhibited a visual color change with the concentration of the OPs under sunlight. Moreover, satisfactory recoveries ranging from 93.3% to 103.6% were obtained for the real samples. The results indicated that the Ru(bpy)₃²⁺-ZIF-90-MnO₂-based OP sensing platform is promising for applications in food safety and environmental monitoring.

Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 10111-08-7.

Li, Jingyao;Di Lorenzo, Vincenzo;Patil, Pravin;Ruiz-Moreno, Angel J.;Kurpiewska, Katarzyna;Kalinowska-Tluscik, Justyna;Velasco-Velazquez, Marco A.;Doemling, Alexander research published 《 Scaffolding-Induced Property Modulation of Chemical Space》, the research content is summarized as follows. Tetrazole- and heterocycle-containing amino alcs. were prepared by Ugi reactions; the amino alcs. underwent cyclization reactions with carbonyl-, thiocarbonyl-, and sulfonyldiimidazole to yield cyclized products, including benzoxazinones and benzoxazepanones, such as I. Two pyrrole- and imidazole-containing amines were also prepared using Ugi reactions; cyclization reactions with carbonyldiimidazole yielded fused imidazolidinones. The properties (lipophilicity, polar surface area, mol. shape) of virtual libraries of uncyclized and cyclized products were compared. The structures of five of the cyclized products were determined by X-ray crystallog.

Synthetic Route of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Synthetic Route of 250285-32-6.

Li, Jiayi;Wang, Liding;Zhao, Zifeng;Li, Xiaoyue;Yu, Xiao;Huo, Peihao;Jin, Qionghua;Liu, Zhiwei;Bian, Zuqiang;Huang, Chunhui research published 《 Two-Coordinate Copper(I)/NHC Complexes: Dual Emission Properties and Ultralong Room-Temperature Phosphorescence》, the research content is summarized as follows. As a kind of photoluminescent material, Cu^I complexes have many advantages such as adjustable emission, variable structures, and low cost, attracting attention in many fields. In this work, two novel two-coordinate Cu^I-N-heterocyclic carbene complexes were synthesized, and they exhibit unique dual emission properties, fluorescence and phosphorescence. The crystal structure, packing mode, and photophys. properties under different conditions were systematically studied, proving the emissive mechanism to be the locally excited state of the carbazole group. Based on this mechanism, ultralong room-temperature phosphorescence (RTP) with a lifetime of 140 ms is achieved by selective deuteration of the carbazole group. These results deepen the understanding of the luminescence mechanism and design strategy for two-coordinate Cu^I complexes, and prove their potential in applications as ultralong RTP materials.

Synthetic Route of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Reference of 60-56-0.

Li, Jianhua;Hussain, Zahir;Zhu, Junjie;Lei, Saifei;Lu, Jie;Ma, Xiaochao research published 《 Role of CYP2A6 in Methimazole Bioactivation and Hepatotoxicity》, the research content is summarized as follows. Methimazole (MMI) is a widely used antithyroid drug, but it can cause hepatotoxicity by unknown mechanisms. Previous studies showed that the hepatic metabolism of MMI produces N-methylthiourea, leading to liver damage. However, the specific enzyme responsible for the production of the toxic metabolite N-methylthiourea is still unclear. In this study, we screened cytochromes P 450 (CYPs) in N-methylthiourea production from MMI. CYP2A6 was identified as the key enzyme in catalyzing MMI metabolism to produce N-methylthiourea. When mice were pretreated with a CYP2A6 inhibitor, formation of N-methylthiourea from MMI was remarkably reduced. Consistently, the CYP2A6 inhibitor prevented MMI-induced hepatotoxicity. These results demonstrated that CYP2A6 is essential in MMI bioactivation and hepatotoxicity.

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Reference of 60-56-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Related Products of 60-56-0.

Li, Fen-Fen;Zhao, Wen-Hao;Tangadanchu, Vijai Kumar Reddy;Meng, Jiang-Ping;Zhou, Cheng-He research published 《 Discovery of novel phenylhydrazone-based oxindole-thiolazoles as potent antibacterial agents toward Pseudomonas aeruginosa》, the research content is summarized as follows. With the soaring of bacterial infection and drug resistance, it is imperative to exploit new efficient antibacterial agents. This work constructed a series of unique phenylhydrazone-based oxindole-thiolazoles to combat monstrous bacterial resistance. Some target mols. showed potent antibacterial activity, among which oxindole-thiolimidazole derived carboxyphenylhydrazone 4e exhibited an 8-fold stronger inhibitory ability than norfloxacin on the growth of P. aeruginosa, with MIC value of 1 μg/mL. Compound 4e with imperceptible hemolysis could hamper bacterial biofilm formation and significantly impede the development of bacterial resistance. Subsequent mechanism studies demonstrated that 4e could destruct bacterial cytoplasmic membrane, causing the leakage of cellular contents (protein and nucleic acid). Moreover, metabolic stagnation and intracellular oxidative stress caused by 4e expedited the death of bacteria. Furthermore, mol. 4e existed supramol. interactions with DNA to block DNA proliferation. These research results provided a promising light for phenylhydrazone-based oxindole-thiolazoles as novel potential antibacterial agents.

Related Products of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Li, Dazhi;Ollevier, Thierry research published 《 Mechanism studies of oxidation and hydrolysis of Cu(I)-NHC and Ag-NHC in solution under air》, the research content is summarized as follows. The decomposition of copper(I)-NHC and silver-NHC complexes in solution under air was studied. The Cu(I)-NHCs were oxidized into urea derivatives and hydrolyzed into imidazoliums or benzimidazoliums. The decomposition of Ag-NHC with a saturated backbone led to ring-opening product, while the Ag-NHC with an unsaturated backbone led to imidazolium and Ag-bisNHC complex. The effects of steric property, hydrophilicity, and binding energy of NHC to O₂ and H₂O on the decomposition of Cu(I)-NHC were studied using theor. calculations Steric hindrance played an important role on the stability of Cu(I)-NHC. Pathways for the decomposition of Cu(I)-NHC and Ag-NHC were proposed.

Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Quality Control of 250285-32-6.

Li, Dan;Tian, Qingqiang;Wang, Xuetong;Wang, Qiang;Wang, Yin;Liao, Siwei;Xu, Ping;Huang, Xin;Yuan, Jianyong research published 《 N-Heterocyclic carbene palladium (II)-pyridine (NHC-Pd (II)-Py) complex catalyzed heck reactions》, the research content is summarized as follows. A mild, efficient, and practical catalytic system for the synthesis of highly privileged stilbene pharmacophores was reported. This system used N-heterocyclic carbene palladium (II) Pyridine (NHC-Pd (II)-Py) complex to catalyze the formation of carbon-carbon bonds between olefin derivatives and various bromide. This simple, gentle and user-friendly method offered a variety of stilbene products in excellent yields under solvent-free condition. And its scale-up reaction had excellent yield and this system can be applied to industrial fields. The utility of this method was highlighted by its universality and modular synthesis of a series of bioactive mols. or important medical intermediates.

Quality Control of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Synthetic Route of 1739-84-0.

Li, Beibei;Xu, Conglei;Yu, Danning;Qi, Ziyuan;Wang, Yifei;Peng, Yongzhen research published 《 Enhanced phosphate remediation of contaminated natural water by magnetic zeolitic imidazolate framework-8@engineering nanomaterials (ZIF8@ENMs)》, the research content is summarized as follows. The efficient enrichment and reutilization of phosphate from natural water still remains a daunting challenge to satisfy the increasingly stringent phosphate discharge criteria. In response to this problem, the presented study successfully synthesizes a series of magnetic zeolitic imidazolate framework-8@engineering nanomaterials (ZIF8@ENMs) via a two-step hydrothermal and coprecipitation method by facilely growing ZIF8 and/or Fe₃O₄ on various functional ENMs. Structure morphol., chem. composition and hysteresis curve characterizations demonstrate the successful formation of magnetic Fe₃O₄-ZIF8@ENM. Amongst the prepared magnetic ZIF8@ENMs hybrids, the Fe₃O₄-ZIF8@ENMs possessing massive hydroxyl groups is demonstrated to harvest the maximum adsorption capacity of 441.7 mg g^-1 under neutral condition. Such-acquired adsorption capacity evidently surpass state-of-the-art adsorbents. Systematic assessment of the chem. condition effects on phosphate removal, revealing its conspicuous merits of robust pH independence (94.63-98.20%), high selectivity pinpointing phosphate within complex cations, ease-of-separation and satisfactory recycle. The outstanding performance of magnetic ZIF8@ENMs are mainly derived from the formed strong Zn-O-P, Fe-O-P and electrostatic interactions between phosphate and adsorbents. Along this line, designing magnetic MOFs-based hybrids towards phosphate are anticipated to be promising avenues for advanced treatment of phosphate-like contaminants and efficient recycle in practical applications.

Synthetic Route of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. HPLC of Formula: 10111-08-7.

Li, Baicun;Zhu, Feifeng;He, Fengming;Huang, Qingqing;Liu, Xiaoguang;Wu, Tong;Zhao, Taige;Qiu, Yingkun;Wu, Zhen;Xue, Yuhua;Fang, Meijuan research published 《 Synthesis and biological evaluations of N’-substituted methylene-4-(quinoline-4-amino)benzoylhydrazides as potential anti-hepatoma agents》, the research content is summarized as follows. In the effort to develop novel quinoline derivatives for the treatment of liver cancer, a series of N’-substituted methylene-4-(quinoline-4-amino)benzoyl hydrazides I (R = n-Pr, 2,6-(MeO)₂C₆H₃, 1H-benzo[d]imidazole-2-yl, etc.) was synthesized and evaluated for their biol. activities as anticancer agents. Compounds I [R = 3,4-dimethoxyphenyl (II), 2,5-dihydroxyphenyl (III)] were found to be the most potent antiproliferative agents against HepG2 cell line with an IC₅₀ value of 12.6 ± 0.1μM and 27.3 ± 1.7μM, resp. Compound II also exhibited potent cytotoxicity against SMMC-7721 and Huh7 cells with IC₅₀ values of 9.6 ± 0.7μM and 6.3 ± 0.2μM, resp. Inspiringly, both II and III exhibited lower cytotoxic property in normal cells than hepatic carcinoma cells. Compounds II and III could down-regulate mRNA level of c-Myc and expression level of c-Myc. Meanwhile, they decreased expression level of anti-apoptotic protein Bcl-2 and increased expression levels of pro-apoptotic protein Bax and cleaved PARP with reference to tubulin. So various assays including cell colony formation, cell cycle distribution, as well as cell apoptosis and migration were performed to understand their antitumor role. It was confirmed that II and III inhibited the growth of HepG2 cells due to their anti-survival effect, induction of cell cycle arrest and cell apoptosis, and inhibition of cell migration. These results demonstrated that II might be a potential lead compound to develop anticancer agents for the treatment of hepatocellular carcinoma.

HPLC of Formula: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Quality Control of 10111-08-7.

Lei, Zhiwen;Shen, Jinlai;Wang, Jun;Qiu, Qi;Zhang, Guangzhao;Chi, Shang-Sen;Xu, Hongli;Li, Shuai;Zhang, Weide;Zhao, Yusheng;Deng, Yonghong;Wang, Chaoyang research published 《 Composite polymer electrolytes with uniform distribution of ionic liquid-grafted ZIF-90 nanofillers for high-performance solid-state Li batteries》, the research content is summarized as follows. The stable structure, high porosity and surface functionality endow metal organic frameworks (MOFs) nanoparticles as excellent nanofillers for high-performance poly (ethyleneoxide)-based solid polymer electrolytes (PEO SPEs). However, the agglomeration of MOFs severely limits their potential applications. Herein, a novel zeolitic imidazolate framework-90 nanofiller grafted with imidazole ionic liquid containing siloxane groups (ZIF-90-g-IL) is prepared by dehydration condensation reaction, which enables the uniform distribution of the nanofiller in PEO SPEs. The resulting composite PEO SPE with ZIF-90-g-IL nanofillers delivers higher ionic conductivity of 1.17 x 10-4 S/cm at 30°C and lithium ion transference number of 0.44, wider electrochem. stability window of 4.8 V, and stronger ability to inhibit lithium dendrite growth than the PEO SPE with unmodified ZIF-90. The strong interaction of ZIF-90-g-IL with PEO is caused by the chelation of quaternary ammonium cations of ionic liquid groups on the ZIF-90-g-IL surface with oxygen containing a lone pair of electrons of PEO, resulting in a uniform distribution of the nanofillers in PEO. The LFP||Li half cells with the PEO/ZIF-90-g-IL SPE exhibit good cycling performance with 71% capacity retention (101 mAh g-1) after 500 cycles at 2C under 60°C, and show excellent cycling performance with 97.4% capacity retention (148 mAh g-1) after 30 cycles at 0.1C under 30°C. The composite SPE is also used for high-voltage NCM811||Li half cells. The capacity retention is 63% (99 mAh g-1) after 100 cycles at 0.1C under 60°C. The results imply ZIF-90-g-IL as effective nanofillers for SPEs showing a great potential application in all solid-state lithium metal batteries.

Quality Control of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem