Author: Jessica.F

The author of 《Straightforward synthesis of [Au(NHC)X] (NHC = N-heterocyclic carbene, X = Cl, Br, I) complexes》 were Collado, Alba; Gomez-Suarez, Adrian; Martin, Anthony R.; Slawin, Alexandra M. Z.; Nolan, Steven P.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2013. Recommanded Product: 852445-84-2 The author mentioned the following in the article:

An improved protocol for the synthesis of [Au(NHC)X] (X = Cl, Br, I) complexes is reported. This versatile 1-step synthetic methodol. proceeds under mild conditions, in air, using tech. grade solvents, is scalable and is applicable to a wide range of imidazolium and imidazolidinium salts. Optimized conditions include reaction of [Au(SMe2)Cl] with the corresponding 1,3-disubstituted imidazolium or imidazolidinium (NHC).HX salts (same X) in acetone with 1 equiv K2CO3 base for 1 h at 60°, affording 53-97% yields of [Au(NHC)X] complexes. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Recommanded Product: 852445-84-2) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Recommanded Product: 852445-84-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,International Journal of Biological Macromolecules included an article by Noguchi, Seiichiro; Sato, Koki; Yamamoto, Kazuya; Kadokawa, Jun-ichi. Reference of 1-Methyl-1H-imidazole. The article was titled 《Preparation of composite and hollow particles from self-assembled chitin nanofibers by Pickering emulsion polymerization》. The information in the text is summarized as follows:

This study investigated Pickering emulsion polymerization of styrene using self-assembled chitin nanofibers (CNFs) as stabilizers to produce CNF-based composite particles, which were further converted into hollow particles. Previously, we reported that regeneration from a chitin/1-allyl-3-methylimidazolium bromide ion gel using methanol fabricated self-assembled CNFs. Prior to the emulsion polymerization, CNFs were maleylated by reaction with maleic anhydride in the presence of perchloric acid. After styrene was added to a dispersion of the produced anionic CNFs in ammonia aqueous, a mixture was ultorasonicated to give an emulsion, in which styrene droplets were stably surrounded by CNFs. Radical polymerization was then conducted in the presence of potassium persulfate as an initiator to produce the composite particles. Particle sizes became smaller as the amounts of CNFs increased. The hollow particles were prepared by solubilizing out the polystyrene cores with toluene. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Reference of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Reference of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Pareek, Shubhra; Jain, Deepti; Hussain, Shamima; Biswas, Amrita; Shrivastava, Rahul; Parida, Saroj K.; Kisan, Hemanta K.; Lgaz, Hassane; Chung, Ill-Min; Behera, Debasis. Safety of 1H-Benzo[d]imidazol-2-amine. The article was titled 《A new insight into corrosion inhibition mechanism of copper in aerated 3.5 weight% NaCl solution by eco-friendly Imidazopyrimidine Dye: experimental and theoretical approach》. The information in the text is summarized as follows:

A large number of mechanism were anticipated for Cu since 1988 in NaCl medium. The detail electrochem. behavior leading to the anodic dissolution of Cu, however, still remains uncertain. Herein, an Imidazopyrimidine Dye, named, 4-amino-3-(phenyldiazenyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2(1H)-one, (APIP) was used as a Cu corrosion inhibitor in 3.5% (by weight) NaCl solution The present study provides a brief mechanistic overview of the electrochem. mechanism of Cu in aerated NaCl solution, simulating a static marine environment, with and without addition of APIP inhibitor. Potentiodynamic polarization (PDP) results confirmed that the APIP can suppress Cu corrosion effectively at low concentration in 3.5% NaCl solution with an inhibition efficiency of 92.79% due to adsorption, along with the prediction of electrochem. mechanism. Electrochem. impedance spectroscopy (EIS) measurements showed that the corrosion inhibition of Cu proceeds via both diffusion and kinetic controlled processes. Adsorption of APIP on Cu surface is well fit with the Langmuir isotherm model and mode of adsorption is proposed. Antimicrobial activity was also studied and the result obtained showed ”eco-friendly” nature of APIP. Field Emission Scanning Electron Microscope (FE-SEM), Energy dispersion x-ray (EDX) and Attenuated Total Reflectance-FTIR Spectroscopy (ATR-FTIR) observations of the Cu surfaces confirmed the existence of adsorption of APIP thus can be potentially used in industries in which seawater is implied are numerous such as cooling H2O systems, desalination plants, power plants, and oil production units. Results obtained from theor. calculations including quantum chem. d. functional theory (DFT) method and mol. dynamics (MD) simulations confirms the exptl. findings and provide further insight into the mode of adsorption on the Cu surface. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Sheikh, Hamdullah Khadim; Arshad, Tanzila; Habib, Uzma; Mohammad, Zainab Sher; Siddiqui, Maaz Uddin Ahmed; Hassan, Mohtasheemul published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Colorimetric chromophoric rapid detection of SARS-CoV-2 through breath analysis》.Recommanded Product: 7720-39-0 The author mentioned the following in the article:

Early and rapid detection of SARS-CoV-2 in an infected person is one fundamental part of the strategy against the spread of this virus. As of now, the usual practice is to carry out polymerase chain reaction (PCR) test which provides results in 24-48 h. Hence, there exists a crucial need for rapid and immediate screening of people suspected to be infected. Presence of volatile organic compounds (VOCs) in the exhaled breath can be one such prospect for detection of virus. In this paper, we have designed chromophoric adducts of VOC′s in the exhaled breath that can be formed for colorimetric detection of SARS-CoV-2. We noted the bathochromic shift in λ (nm) of VOC mols. upon chromophore formation for colorimetric detection. If adapted, this research work will result in low cost solution to the requirement of immediate detection of SARS-CoV-2, hence cost and time of testing will be reduced, compared to PCR and antibodies tests. Also VOC′s detection in early stage of infection where symptoms are not visible can be advantageous. The experimental part of the paper was very detailed, including the reaction process of 1H-Imidazol-2-amine(cas: 7720-39-0Recommanded Product: 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gupta, Radhey S. published an article on February 27 ,1987. The article was titled 《Identification of 2-benzimidazolylurea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of CHO cells》, and you may find the article in Biochemical and Biophysical Research Communications.Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole The information in the text is summarized as follows:

The cross-resistance patterns of a set of nocodazole  [31430-18-9]-resistant (NocR) and podophyllotoxin  [518-28-5]-resistant (PodR) mutants of Chinese hamster ovary cells, which exhibit highly-specific cross-resistance toward compounds that show nocodazole-like antimitotic activity, towards a large number of benzimidazole derivatives was examined Of the various compounds examined, the NocR and the PodR mutants were found to exhibit increased cross-resistance towards only 2-benzimidazolylurea  [24370-25-0], indicating that this compound may possess similar biol. activity as nocodazole. The nocodazole-like antimitotic activity of 2-benzimidazolylurea was confirmed by its ability to block cells in mitosis, and by its competition of [3H]podophyllotoxin binding to microtubule proteins in cell extracts The nocodazole-like behavior of 2-benzimidazolylurea and lack of similar activity in other benzimidazole derivatives examined, provides valuable information regarding structural features that are required for this type of biol. activity. After reading the article, we found that the author used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Hattori, Yohei; Kitajima, Ryota; Matsuoka, Ryota; Kusamoto, Tetsuro; Nishihara, Hiroshi; Uchida, Kingo. Category: imidazoles-derivatives. The article was titled 《Amplification of luminescence of stable radicals by coordination to NHC-gold(I) complex》. The information in the text is summarized as follows:

Gold NHC pyridine complexes I·SbF6 (R = 2,6-iPr2C6H3, 2,4,6-Me3C6H2, Cy, Me; X = H, X-X = benzo), substituted by stable radical in pyridine 4-position, were prepared and examined for photoluminescence properties. The luminescence of stable radicals can be enhanced by coordination to metal complexes. The 4% fluorescence quantum yield of (3,5-difluoro-4-pyridyl)bis(2,4,6-trichlorophenyl)methyl radical (F2PyBTM) in dichloromethane was enhanced up to 36% by coordination to AuI with N-heterocyclic carbene ligand, which is a record for metal-radical complexes.Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Category: imidazoles-derivatives) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Avoiding Pre-Isolation Step in Exosome Analysis: Direct Isolation and Sensitive Detection of Exosomes Using Gold-Loaded Nanoporous Ferric Oxide Nanozymes》 were Boriachek, Kseniia; Masud, Mostafa Kamal; Palma, Carlos; Phan, Hoang-Phuong; Yamauchi, Yusuke; Hossain, Shahriar A. Md.; Nguyen, Nam-Trung; Salomon, Carlos; Shiddiky, Muhammad J. A.. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. COA of Formula: C10H16N2O3S The author mentioned the following in the article:

Most of the current exosome-anal. strategies are time-consuming and largely dependent on com. extraction kit-based preisolation step, which requires extensive sample manipulations, costly isolation kits, reagents, tedious procedures, and sophisticated equipment and is prone to bias/artifacts. Herein we introduce a simple method for direct isolation and subsequent detection of a specific population of exosomes using an engineered superparamagnetic material with multifunctional properties, namely, gold-loaded ferric oxide nanocubes (Au-NPFe2O3NC). In this method, the Au-NPFe2O3NC were initially functionalized with a generic tetraspanin (exosomes-associated) antibody (i.e., CD63) and dispersed in sample fluids where they work as “”dispersible nanocarriers”” to capture the bulk population of exosomes. After magnetic collection and purification, Au-NPFe2O3NC-bound exosomes were transferred to the tissue-specific, antibody-modified, screen-printed electrode. As a proof of principle, we used a specific placental marker, placenta alk. phosphatase (PLAP), to detect exosomes secreted from placental cells. The peroxidase-like activity of Au-NPFe2O3NC was then used to accomplish an ELISA-based sensing protocol for naked-eye observation along with UV-visible and electrochem. detection of PLAP-specific exosomes present in placental cell-conditioned media. We demonstrated excellent agreement in anal. performance for the detection of placental cell-derived exosomes (i.e., linear dynamic range, 103-107 exosomes/mL; limit of detection, 103 exosomes/mL; relative standard deviation (%RSD) of <5.5% for n = 3) using with and without com. ""total exosome isolation kit""-based preisolation step. We envisage that this highly sensitive, rapid, and inexpensive assay could be useful in quantifying specific populations of exosomes for various clin. applications, focusing on pregnancy complications. The experimental process involved the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5COA of Formula: C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.COA of Formula: C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《N-Heterocyclic carbene (NHC)-catalyzed tandem imine umpolung-aza-Michael addition-oxidation of β-carboline cyclic imines》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Satyam, Killari; Harish, Battu; Nanubolu, Jagadeesh Babu; Suresh, Surisetti. Application of 141556-45-8 The article mentions the following:

An NHC-catalyzed umpolung of β-carboline-based cyclic imines for their conversion to the corresponding N-substituted cyclic amides. The key to the success of this transformation appears to be that NHC upon reaction with the imine concomitantly goes through the generation of an aza-Breslow intermediate and aza-Michael addition followed by oxidation with mol. oxygen to deliver the N-substituted amide products. The developed method has enabled the synthesis of various biol. relevant β-carboline-1-one derivatives in good yields. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《An AIE-active probe for selective fluorometric-colorimetric detection of HSO3- in aqueous solution and real samples》 was written by Han, Jia Hong; Gao, Wen Ying; Feng, Li Heng; Wang, Yu; Shuang, Shao Min. COA of Formula: C7H7N3 And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2021. The article conveys some information:

We report herein a new biphenylcarbonitrile derivative, 4′-hydroxy-3′ -((2-imidazolylimino) methyl)-4-biphenyl carbonitrile (HIBC), which interestingly exhibits an aggregation-induced emission property. HIBC was employed for selective dual mode (fluorimetric and colorimetric) assay of HSO3- ions in nearly 100% aqueous medium at pH 7.4. The nucleophilic addition of HSO3- on the imino group in HIBC breaks its π-electron conjugation and results in a noticeable absorption and fluorescence spectral changes accompanied by a visible color change. Moreover, the formation of anionic addition product weakened the aggregation effect and meanwhile inhibited ESIPT process in HIBC, causing quenching of keto fluorescence of the probe. The probe shows good selectivity for HSO3- ions over all other competitive anions, which renders it a promising candidate for ratiometric fluorescent assay of HSO3- in aqueous systems. The limit of detection is 1.83 x 10-7 mol/L. For the practical applicability, handy paper strips were fabricated from HIBC for convenient recognition of HSO3-. Addnl., HIBC was applied for the living HeLa cells bio-imaging. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Borges-Munoz, Amaris; Patel, Harshkumar; Tattersall, Peter published an article in Journal of Pharmaceutical and Biomedical Analysis. The title of the article was 《Derivatization and determination of residual N,N-Carbonyldiimidazole by LC for an in-process control test》.Recommanded Product: Di(1H-imidazol-1-yl)methanone The author mentioned the following in the article:

For the robust anal. of N,N-Carbonyldiimidazole (CDI), its derivatization into a more stable compound may be needed. Herein, the reaction of CDI with N-benzylmethylamine followed by LC-UV quant. anal. was explored. Reaction conditions as well as LC method feasibility were demonstrated by qualification of selectivity from other impurities and reagents, linearity across a range of 0.05-0.15%weight/weight, spike and recovery across a range of 0.05-0.15%weight/weight, reaction reproducibility with various samples, reagents and anal. chemists, and sample stability of over 24 h. Rapid and quant. derivatization of residual CDI was achieved at 0.1% weight/weight relative to the synthetic product under consideration. A fit-for-purpose limit test using a RPLC-UV method as an in-process control for the reaction completion of product, at scale, was successfully implemented and executed. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem