Author: Jessica.F

In 2017,Jeyaleela, G. Dayana; Monisha, S. Irudaya; Vimala, J. Rosaline; Immaculate, A. Anitha published 《Isolation of 2-chlorobenzimidazole from Melia dubia leaf extract and its structural characterisation》.International Journal of Pharmacy and Pharmaceutical Sciences published the findings.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:

Objective: Natural products from medicinal plants, either as isolated compounds or as standardized plant extracts exhibit promising source of medicinal activity against various diseases. The aim of the present work was to make an attempt of isolation of bioactive principle and characterization of the isolated compound, from the medicinal plant Melia dubai Methods: The extraction was done by a cold percolation method and the compound was separated and isolated by chromatog. technique such as a thin layer chromatog. (TLC), column chromatog. and high-performance liquid chromatog. (HPLC). The isolated compound was crystallized and the structural characterization of the isolated compound was made using UV-Visible, FT-IR, 1H-NMR, GC-MS and MS techniques which confirmed the structure of the isolated compound Results: The separated and isolated compound was characterized by both phys. and spectral methods like UV-Visible spectroscopy (UV-Visible), Fourier transform IR spectroscopy (FT-IR), Proton NMR Spectroscopy (1H-NMR), Gas chromatog.-mass spectrometry (GC-MS), and Mass spectrometry(MS). Based on the studies, organizational characteristics of one bioactive principle were deciphered. The results revealed that the isolated species is 2-chlorobenzimidazole and it agreed well with the reported value and spectra for 2-chlorobenzimidazole. Conclusion: The above results obtained in this research work clearly indicated the promising occurrence of 2-chlorobenzimidazole in Media dubia plant leaves. The future scope of these studies may guide us to view the biol. activity of the isolated compound In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Ta, Sabyasachi; Das, Sudipta; Ghosh, Milan; Banerjee, Mahuya; Hira, Sumit Kumar; Manna, Partha Pratim; Das, Debasis. Recommanded Product: 1H-Benzo[d]imidazol-2-amine. The article was titled 《A unique benzimidazole-naphthalene hybrid molecule for independent detection of Zn2+ and N-3 ions: Experimental and theoretical investigations》. The information in the text is summarized as follows:

Single crystal X-ray structurally characterized benzimidazole-naphthalene hybrid (NABI) functions as a unique dual analyte sensor that can detect Zn2+ cation and N-3 anion independently. The NABI forms chelate with Zn2+ to inhibit internal charge transfer (ICT) and -CH=N- isomerization resulting chelation enhanced fluorescence (CHEF). On the other hand, the sensing of N-3 is based on formation of supramol. H-bonded rigid assembly. The association constant of NABI for Zn2+ and N-3 ions are 19 × 104 M-1 and 11 × 102 M-1, resp. Corresponding limit of detections (LOD) are 6.85 × 10-8 and 1.82 × 10-7 M, resp. NABI efficiently detects intracellular Zn2+ and N-3 ions with no cytotoxicity on J774A.1cells under fluorescence microscope. DFT studies unlock underlying spectroscopic properties of free NABI and Zn2+/N-3 bound forms. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota.》 were Sabui, Subrata; Skupsky, Jonathan; Kapadia, Rubina; Cogburn, Kyle; Lambrecht, Nils W; Agrawal, Anshu; Said, Hamid M. And the article was published in American journal of physiology. Gastrointestinal and liver physiology in 2019. Recommanded Product: 58-85-5 The author mentioned the following in the article:

The sodium-dependent multivitamin transporter (SMVT; SLC5A6) is involved in intestinal absorption of vitamin B7 (biotin). We have previously shown that mice with an embryonic intestinal-specific SMVT knockout (KO) develop biotin deficiency and severe spontaneous intestinal inflammation in addition to growth retardation, developmental delays, and death within the first 6-7 wk of life. The profound morbidity and mortality associated with the SMVT-KO has limited our ability to further characterize the intestinal inflammation and other sequelae of this deletion in adult mice with a mature gut microbiota. To overcome this limitation, we generated an intestine-specific, tamoxifen-inducible, conditional SMVT-KO (SMVT-icKO). Our results showed that adult SMVT-icKO mice have reduced body weight, biotin deficiency, shorter colonic length, and bloody diarrhea compared with age- and sex-matched control littermates. All SMVT-icKO mice also developed spontaneous intestinal inflammation associated with induction of calprotectin (S100a8/S100a9), proinflammatory cytokines (IL-1β, TNF-α, IFN-γ, and IL-6), and an increase in intestinal permeability. Additionally, the intestines of SMVT-icKO showed activation of the NF-κB pathway and the nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome. Notably, administration of broad-spectrum antibiotics reduced lethality and led to normalization of intestinal inflammation, proinflammatory cytokines, altered mucosal integrity, and reduced expression of the NLRP3 inflammasome. Overall, these findings support our conclusion that the biotin transport pathway plays an important role in the maintenance of intestinal homeostasis, and that NF-κB and the NLRP3 inflammasome, as well as gut microbiota, drive the development of intestinal inflammation when SMVT is absent.NEW & NOTEWORTHY This study demonstrates that deletion of the intestinal biotin uptake system in adult mice leads to the development of spontaneous gut inflammation and that luminal microbiota plays a role in its development. In the experiment, the researchers used many compounds, for example, 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Recommanded Product: 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Recommanded Product: 58-85-5 And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Detection of miRNAs by tissue printing and dot blot hybridization》 were Nunez, Marcelino Martinez; de Folter, Stefan; de Fatima Rosas-Cardenas, Flor. And the article was published in Methods in Molecular Biology (New York, NY, United States) in 2019. Application of 616-47-7 The author mentioned the following in the article:

Tissue printing and dot blot are simple techniques to detect miRNA expression and localization, allowing a better understanding of the function of a miRNA. The authors describe a tissue printing and a dot blot hybridization protocol for miRNA detection and localization in plant tissues, which opens the possibility of analyzing spatiotemporal expression patterns of miRNAs. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Application of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Application of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis and biological evaluation of some novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids as potential antifungal agents》 was published in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. These research results belong to Perez, Ser John Lynon P.; Atayde, Eduardo C. Jr.; Arco, Susan D.. Name: 1-Methyl-1H-imidazole The article mentions the following:

In an effort to discover lead compounds that may be of importance as potent antifungal agents, a series of novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids were efficiently synthesized through a solvent-free ultrasound-assisted quaternization reaction of 1-methylimidazole and alkyl bromides RBr (R = hexyl, octyl) followed by an anion exchange process with selected carboxylate anions (cinnamate, salicylate, crotonate, and oxalate). Quant. yields obtained were in the range of 86-94%. Structure characterization was done using FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. All the synthesized compounds showed in vitro antifungal activity against the fungus Candida albicans with the min. inhibitory concentrations found to be less than or equal to 1%. Preliminary cytotoxicity assays (trypan blue exclusion and MTT) were performed on all ionic liquids and findings revealed higher lymphocyte viability in 1-hexyl-3-methylimidazolium carboxylate ionic liquids than in 1-octyl-3-methylimidazolium counterparts. No extensive toxicity effect was observed with the carboxylate anion variation. Among the tested compounds, 1-hexyl-3-methylimidazolium crotonate and 1-hexyl-3-methylimidazolium oxalate exhibited the lowest cytotoxicity in the trypan blue exclusion and MTT assays, resp. Together, our results highlight the potential of carboxylate-based ionic liquids in the development of next-generation antifungal drugs. In the experiment, the researchers used 1-Methyl-1H-imidazole(cas: 616-47-7Name: 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Name: 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2021 ,《4H-Chromenes as 1,3-bielectrophiles in the reaction with 2-aminobenzimidazole: synthesis of pyrimido[1,2-a]benzimidazoles》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Osyanin, Vitaly A.; Osipov, Dmitry V.; Korzhenko, Kirill S.; Demidov, Oleg P.; Klimochkin, Yuri N.. The article conveys some information:

A method for the preparation of pyrimido[1,2-a]benzimidazoles containing a 2-hydroxybenzyl or (2-hydroxynaphthalen-1-yl)methyl group at position 3 was proposed based on the reaction of β-carbonyl-substituted 4H-chromenes and their benzo analogs with 2-aminobenzimidazole. In the case of chromenes substituted in the methylene fragment, 7,13a-dihydro-5H-benzo[5′,6′]chromeno-[3′,2′:5,6]pyrimido[1,2-a]benzimidazoles were isolated. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis, crystal structure and Hirshfeld surface analysis of N-(4-chlorophenyl)-5-cyclopropyl-1-(4-methoxyphenyl)-1H-1,2,3-triazole-4-carboxamide》 was published in Acta Crystallographica, Section E: Crystallographic Communications in 2020. These research results belong to Pokhodylo, Nazariy; Slyvka, Yurii; Pavlyuk, Volodymyr. Computed Properties of C7H6N4O The article mentions the following:

The title compound, C19H17ClN4O2, was obtained via a two-step synthesis involving the enol-mediated click Dimroth reaction of 4-azidoanisole with Me 3-cyclopropyl-3-oxopropanoate leading to the 5-cyclopropyl-1-(4-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylic acid and subsequent acid amidation with 4-chloroaniline by 1,1′-carbonyldiimidazole (CDI). It crystallizes in space group P21/n, with one mol. in the asym. unit. In the extended structure, two mols. arranged in a near coplanar fashion relative to the triazole ring planes are interconnected by N-H···N and C-H···N hydrogen bonds into a homodimer. The formation of dimers is a consequence of the above interaction and the edge-to-face stacking of aromatic rings, which are turned by 58.0 (3)° relative to each other. The dimers are linked by C-H···O interactions into ribbons. DFT calculations demonstrate that the frontier MOs are well separated in energy and the HOMO is largely localized on the 4-chlorophenyl amide motif while the LUMO is associated with aryltriazole grouping. A Hirshfeld surface anal. was performed to further analyze the intermol. interactions. After reading the article, we found that the author used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Computed Properties of C7H6N4O)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Computed Properties of C7H6N4O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Materials Chemistry A: Materials for Energy and Sustainability included an article by Ying, Wen; Hou, Quangang; Chen, Danke; Guo, Yi; Li, Zhuoyi; Zhang, Jun; Yan, Youguo; Peng, Xinsheng. Synthetic Route of C8H15BF4N2. The article was titled 《Electrical field facilitates selective transport of CO2 through a laminated MoS2 supported ionic liquid membrane》. The information in the text is summarized as follows:

Ionic liquid (IL), a neutral assembly of charged ions, is a potential material for CO2 capture and storage. The practicality of IL can be improved by confining it into porous substrates and nanopores, which will further enhance the performance of IL by changing its structure. Addnl., an external elec. field (EEF) should also affect the IL structure through its charged components. In this work, an EEF is applied on a MoS2 supported ionic liquid membrane (MoS2-SILM) to selectively facilitate CO2 transport by the dual effect of MoS2 nanochannel and EEF. The redistribution of nanoconfined IL under an EEF resulted in the increase in free volume of IL and decrease in anion-cation interactions, which led to the enhancement of CO2 solubility and diffusion, and further, the permeance. Compared with the MoS2-SILM without an EEF, the CO2 permeance was enhanced from 89-200 GPU, and the selectivity of CO2/H2, CO2/CH4 and CO2/N2 was also enlarged 2-3 times. An interesting phenomenon was the asym. CO2 separation performance affected by the CO2 adsorbed on MoS2 nanosheets under a pos. and neg. EEF, which may establish a new strategy to design high-performance gas separation membranes. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Synthetic Route of C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Synthetic Route of C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kumar, Ravinder; Mathur, Pavan published an article on February 5 ,2015. The article was titled 《Oxidation of phenyl propyne catalyzed by copper(II) complexes of a benzimidazolyl Schiff base ligand: Effect of acid/base, oxidant, surfactant and morphology》, and you may find the article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy.SDS of cas: 53332-79-9 The information in the text is summarized as follows:

Copper(II) complexes, Cu(L)X (X = Cl-, NO3-, NCS-) with a new N-substituted benzimidazole Schiff base ligand (HL) derived from 2-hydroxy-1-naphthaldehyde and N-methyl-2-(aminomethyl)benzimidazole, were used as catalyst for the oxidation of 1-phenylpropyne. The oxidation is carried out under mild conditions using stoichiometric amounts of oxidant and catalytic amounts of Cu(II) complex as catalyst. Effect of acid/base, oxidant, morphol. and surfactant was studied. Two major products of 1-phenylpropyne oxidation are the α-diketonic product, PhCOCOMe, and a terminal aldehyde, PhCCCHO. Diketone is the major product under acidic conditions while aldehyde formation is highest under basic conditions. The maximum conversion is found with the NO3- bound complex. GC-MS was used to find the percentage yields of products. SEM and PXRD of the reused complexes as catalyst suggest that morphol. affects the catalytic efficiency. In the experiment, the researchers used [(1-Methyl-1H-benzimidazol-2-yl)methyl]amine dihydrochloride(cas: 53332-79-9SDS of cas: 53332-79-9)

[(1-Methyl-1H-benzimidazol-2-yl)methyl]amine dihydrochloride(cas: 53332-79-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. SDS of cas: 53332-79-9 In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Tekuri, Venkatadri; Sahoo, Suban K.; Trivedi, Darshak R.. Recommanded Product: 934-32-7. The article was titled 《Hg2+ induced hydrolysis of thiazole amine based Schiff base: Colorimetric and fluorogenic chemodosimeter for Hg2+ ions in an aqueous medium》. The information in the text is summarized as follows:

Simple pyrene-based chemosensors 1 to 3, were synthesized from pyrene-1-carboxaldehyde and they were characterized using various spectroscopic techniques like UV-Vis, FT-IR, Mass, 1H NMR and 13C NMR. Among synthesized receptors, the receptor 1 shows high selectivity towards Hg2+ ions. Further, the high selectivity of receptor 1 towards Hg2+ ions in the presence of various other interfering metal ions like Ni2+, Zn2+, Mn2+, Co2+, Cu2+, Cr3+, Fe3+, Al3+, Ag+, Fe2+, Cd2+, Mg2+, Pb2+, Ca2+, Na+, K+ was confirmed by UV-Vis and fluorescence methods. The detection limit for Hg2+ ions was found to be 0.270 μM. The chemodosimetric irreversible hydrolysis of the receptor 1 in the presence of Hg2+ was studied by UV/Vis, fluorescence, FT-IR, LC-MS, 1H NMR and theor. DFT study. Further, the real life applications of receptor 1 for the determination of Hg2+ ions were demonstrated by UV-Vis method. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem