Author: Jessica.F

Thermophysical Properties of Imidazolium-Functionalized Binols and Their Application in Asymmetric Catalysis was written by Vidal, Marc;Schmitzer, Andreea R.. And the article was included in Organometallics in 2014.Name: 1-Octyl-1H-imidazole This article mentions the following:

We report here the thermophys. properties of a new family of imidazolium-functionalized binaphthols, e.g., I (R = Me, n-Bu, n-C₈H₁₇, C₁₂H₂₅, C₁₆H₃₃, X = NTf₂, BF₄, OTf). These properties are influenced by the position of the imidazolium moieties on the binaphthol skeleton, the counteranions, and the length of the carbon chain on the imidazolium moieties. The ionic character of these mols. was also exploited to develop ligands for the catalytic aldehyde ethylation reaction in ionic liquid media. We were able to easily recover both the ionic ligands and the ionic liquid solvent, and the reaction afforded good to excellent yields, with average selectivity. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition was written by Safina, Brian S.;Baker, Stewart;Baumgardner, Matt;Blaney, Paul M.;Chan, Bryan K.;Chen, Yung-Hsiang;Cartwright, Matthew W.;Castanedo, Georgette;Chabot, Christine;Cheguillaume, Arnaud J.;Goldsmith, Paul;Goldstein, David M.;Goyal, Bindu;Hancox, Timothy;Handa, Raj K.;Iyer, Pravin S.;Kaur, Jasmit;Kondru, Rama;Kenny, Jane R.;Krintel, Sussie L.;Li, Jun;Lesnick, John;Lucas, Matthew C.;Lewis, Cristina;Mukadam, Sophie;Murray, Jeremy;Nadin, Alan J.;Nonomiya, Jim;Padilla, Fernando;Palmer, Wylie S.;Pang, Jodie;Pegg, Neil;Price, Steve;Reif, Karin;Salphati, Laurent;Savy, Pascal A.;Seward, Eileen M.;Shuttleworth, Stephen;Sohal, Sukhjit;Sweeney, Zachary K.;Tay, Suzanne;Tivitmahaisoon, Parcharee;Waszkowycz, Bohdan;Wei, Binqing;Yue, Qin;Zhang, Chenghong;Sutherlin, Daniel P.. And the article was included in Journal of Medicinal Chemistry in 2012.Category: imidazoles-derivatives This article mentions the following:

PI3Kδ is a lipid kinase and a member of a larger family of enzymes, PI3K class IA(α, β, δ) and IB (γ), which catalyze the phosphorylation of PIP2 to PIP3. PI3Kδ is mainly expressed in leukocytes, where it plays a critical, nonredundant role in B cell receptor mediated signaling and provides an attractive opportunity to treat diseases where B cell activity is essential, e.g., rheumatoid arthritis. We report the discovery of novel, potent, and selective PI3Kδ inhibitors and describe a structural hypothesis for isoform (α, β, γ) selectivity gained from interactions in the affinity pocket. The critical component of our initial pharmacophore for isoform selectivity was strongly associated with CYP3A4 time-dependent inhibition (TDI). We describe a variety of strategies and methods for monitoring and attenuating TDI. Ultimately, a structure-based design approach was employed to identify a suitable structural replacement for further optimization. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Category: imidazoles-derivatives).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient one pot synthesis of benzimidazoles from 2-nitroaniline and PhSiH₃ as reducing agent catalyzed by Pd/C as a heterogeneous catalyst was written by Phatake, Vishal V.;Bhanage, Bhalchandra M.. And the article was included in Tetrahedron Letters in 2021.Electric Literature of C8H8N2 This article mentions the following:

This work reported an efficient route for the synthesis of benzimidazole from o-nitroaniline in the presence of carbon dioxide atm., PhSiH₃ as a reducing agent catalyzed by Pd/C as a catalyst. The more efficient route for the synthesis benzimidazole was developed and various substituted benzimidazoles were synthesized in good to excellent yield. The TBD (1,5,7-Triazabicyclo [4.4.0] dec-5-ene) was selected as a base as it promoted the CO₂ insertion. Benzimidazoles were synthesized through reduction of nitro group followed by cyclization of amine using CO₂ as a carbon source. Moreover, the Pd/C catalyst was recycled upto five recycle run without significant changes in the yield of the product. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice was written by Takemura, Hirohide;Choi, Jae-Hoon;Matsuzaki, Nobuo;Taniguchi, Yuki;Wu, Jing;Hirai, Hirofumi;Motohashi, Reiko;Asakawa, Tomohiro;Ikeuchi, Kazutada;Inai, Makoto;Kan, Toshiyuki;Kawagishi, Hirokazu. And the article was included in Scientific Reports in 2019.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Rings or arcs of fungus-regulated plant growth occurring on the floor of woodlands and grasslands are commonly called “fairy rings”. Fairy chems., 2-azahypoxanthine (AHX), imidazole-4-carboxamide (ICA), and 2-aza-8-oxohypoxanthine (AOH), are plant growth regulators involved in the phenomenon. The endogeny and biosynthetic pathways of AHX and AOH in plants have already been proven, however, those of ICA have remained unclear. We developed a high-sensitivity detection method for FCs including ICA and the endogenous ICA was detected in some plants for the first time. The quant. anal. of the endogenous level of ICA in rice and Arabidopsis were performed using ¹³C-double labeled ICA. In addition, the incorporation experiment and enzyme assay using the labeled compound into rice and partially purified fraction of rice indicated that ICA is biosynthesized from 5-aminoimidazole-4-carboxamide (AICA), a metabolite on the purine metabolic pathway. The relationship between ICA and AHX was also discussed based on quant. anal. and gene expression anal. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kinetic analysis of the complete mechanochemical synthesis of a palladium(II) carbene complex was written by Allenbaugh, Rachel J.;Zachary, Jonathon R.;Underwood, A. Nicole;Bryson, J. Dillion;Williams, Joseph R.;Shaw, Angela. And the article was included in Inorganic Chemistry Communications in 2020.Recommanded Product: 1632-83-3 This article mentions the following:

Benzimidazoline-2-ylidene complexes of palladium(II) were synthesized mechanochem. in a vibratory ball mill. Complete syntheses began with preparation of benzimidiazolium halides from com. available starting materials. These “greener chem.” syntheses proceed in high yield and require minimal purification using environmentally benign solvents. Kinetic anal. shows that liquid assisted grinding impedes the production to benzimidazolium halides while enhancing the production of the palladium-carbene complex. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel Mn(II)-Based Metal-Organic Frameworks Isolated in Ionic Liquids was written by Xu, Ling;Kwon, Young-Uk;de Castro, Baltazar;Cunha-Silva, Luis. And the article was included in Crystal Growth & Design in 2013.HPLC of Formula: 79917-89-8 This article mentions the following:

An unprecedented series of Mn²⁺-based metal-organic framework (MOF) materials prepared and isolated in ionic liquids (ILs) is reported. Ionothermal reactions of Mn(OAc)₂ with H₃btc (benzene-1,3,5-tricarboxylic acid) in two groups of [rmi]X (rmi = 1-alkyl-3-methylimidazolium; r = Et or Pr, X = Cl, Br, or I) ILs produced three slightly different 3D MOFs formulated as [rmi][Mn(btc)] [r = Et (1), Pr (2), and (3)], whose architectures can be envisaged as (3,6)-connected pyr topol. nets. Compounds 1–3 are the preferred products when the metal center is half filled d-shelled Mn with the cations of ILs being [emi]⁺ or [pmi]⁺. The comparison of the ionothermal synthesized M-btc systems suggests a significant combinatorial influence of metal-direction and ILs’ cationic template, contrasting with subtle effect of ILs’ halides on the MOF structures. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation was written by Roberts, Bryan;Liptrot, David;Alcaraz, Lilian. And the article was included in Organic Letters in 2010.SDS of cas: 25676-75-9 This article mentions the following:

A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of salt formation on γ-cyclodextrin solubilization of irbesartan and candesartan and the chemical stability of their ternary complexes was written by Jansook, Phatsawee;Hnin, Hay Marn;Praphanwittaya, Pitsiree;Loftsson, Thorsteinn;Stefansson, Einar. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

Angiotensin II receptor blockers (ARBs) are unstable compounds and have relatively low aqueous solubility, which may hamper their bioavailability. The present study aimed to increase the aqueous solubility of ARBs by the formation of cyclodextrin (CD) inclusion complex and determine their chem. stability in aqueous solutions The pH- solubility of drugs and their phase-solubility profiles were determined, and the results showed that the solubility of drugs increased by forming inclusion complexes with γ-cyclodextrin (γCD) and by increasing their intrinsic solubility in phosphate buffer (pH 7.5). The formation of irbesartan/γCD (IRB/γCD) and candesartan cilexetil/γCD (CAC/γCD) inclusion complexes was confirmed by mol. docking. To enhance the γCD solubilization of drugs, salt formation using various organic salts was also investigated. Of these, Tris was the most powerful, followed by sodium acetate, as they significantly increased the γCD solubilization of IRB and CAC. However, chem. instability was observed, particularly at high salt concentrations, where they provided a higher IRB and CAC solubility Thus, the balance of optimum drug solubility and its chem. stability in aqueous solutions should be considered in formulation development. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Infrared spectra and structure of salts of nitroimidazoles was written by Epishina, L. V.;Slovetskii, V. I.;Osipov, V. G.;Lebedev, O. V.;Khmel’nitskii, L. I.;Sevost’yanova, V. V.;Novikova, T. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1967.COA of Formula: C4H5N3O2 This article mentions the following:

The ir spectra of nitroimidazoles and their salts indicate that salt formation involves only the NO2 group, with the formation of an isoimidazole ring. In polynitroimidazoles (I), only one NO2 group is involved as shown. The N-O absorption bands at �550 and �350 cm.-1 in mononitroimidazoles disappear on salt formation and bands at �180 and �50 cm.-1 appear. In salts of I, some of the N-O absorption in the uncharged NO2 group remains. N-Nitroimidazoles are characterized by an antisym. N-O vibration absorption band at �640 cm.-1 and a sym. one at �330 and �280 cm.-1 The presence of a C(NO2)3 group leads to 3 bands at 1600-1630 cm.-1 and usually to 2 bands at 1300-1325 cm.-1 In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1COA of Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) amino-protecting group: use in the solid-phase synthesis of pyrrole-imidazole polyamides was written by Choi, Jin Seok;Lee, Younjoo;Kim, Eunmyoung;Jeong, Nakcheol;Yu, Hosung;Han, Hogyu. And the article was included in Tetrahedron Letters in 2003.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chem. using two Tsc-protected amino acids I (X = CH, N). In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem