Author: Jessica.F

Electric Literature of 641571-11-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 641571-11-1 as follows.

Example 30[00103] Form A of the free base of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl] -3 -(4-pyridin-3 -yl-pyrimidin-2-ylamino)-benzamide is made according to the following scheme:Eq.)10 EPO [00104] 14.5 g (60.0 mmol) of B6 and 20.8 g (64.8 mmol) of B5 are dissolved in 120 niL tetrahydrofuran absolute at room temperature under inert and water-free conditions. The suspension is cooled to IT 0-5C and 101.0 g (180 mmol) of potassium tert-butoxide solution 20% in tetrahydrofuran were added within 1 hour, maintaining the internal temperature at 0-5C. The reaction mixture is heated gradually to IT 5O0C within 1 hour and then stirred at this temperature for another 1 hour. The reaction mixture (yellow suspension) is quenched at IT 50C by the addition of 50 mL of water. Stirring is stopped, and the two phase system is let to separate. The aqueous (lower) phase is removed. Seeding crystals (0.2 g) of form A are added to the remaining organic phase, and the thin suspension is stirred for 1 hour at 500C during which time crystallization is initiated. Approximately 1.0 mL of acetic acid is added to the organic phase until a pH of ~10 is reached. Solvent (260 mL) is distilled off at 80-1000C (external temperature) under normal pressure, and simultaneously 260 mL ethanol 94% is added keeping the volume constant, i.e., solvent exchange from tetrahydrofuran to ethanol. The suspension is cooled to IT 0-50C within 1 hour, and agitation is continued for another 1 hour. Form A of the free base of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl] -3 -(4-pyridin-3 -yl-pyrimidin-2-ylamino)-benzamide (crystalline solid) is collected by filtration and washed with 150 mL of cold ethanol 94%. The product is then dried at 500C in vacuo.

According to the analysis of related databases, 641571-11-1, the application of this compound in the production field has become more and more popular.

Application of 21252-69-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21252-69-7, name is 1-Octyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 1,2-Dimethyl imidazole (9.61 g; 0.10 mol) and trimethylphosphate (14.01 g; 0.10 mol) were mixed at room temperature under argon and vigorous stirring, then heated to 80°C and stirred at this temperature for 1h. Acetonitrile (20 mL) was added and the mixture was stirred at 80°C for 23h. The mixture was left at room temperature, the precipitate was separated,washed twice with acetonitrile and dried under vacuum (2 Torr) for 4 h at 80°C.

The synthetic route of 1-Octyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference of 137049-00-4, The chemical industry reduces the impact on the environment during synthesis 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life.

Intermediate 27 (40 mg, 79 mumol) was dissolved in 1 mL of pyridine and flushed with nitrogen, It was cold to 0 C. and added 1-methyl-1 H-imidazole-4-sulfonyl chloride (43,mg, 240 mumol). The mixture was allowed to warm to room temperature and stirred for 20 h under nitrogen. The reaction was diluted with 10 mL of EtOAc, washed with brine, dried over Na2SO4 and concentrated in vacuum to give crude product which was then purified by flash chromatography on silica gel (20% to 50% ethyl acetate in hexane, then 5/5/1 of EtOAc/hexane/MeOH) to provide 55 (24 mg, 47%). m/z=648 (M+1). The deprotection of the DPM group at C8-OH was carried out as in the conversion of 28 to 29. The resulting residue was then purified by reverse-phase prep HPLC to provide 13 mg (59% in yield) of 56 as a TFA salt. 300 MHz 1H NMR (CDCl3) delta (ppm): 9.0 (d, 1H); 8.4 (d, 1H); 7.5 (m, 1H); 7.4 (s, 1H); 7.3 (m, 2H); 7.2 (s, 1H); 7.0 (t, 2H); 4.8 (s, 2H); 4.3-4.5 (m, 2H); 3.6 (s, 3H); 3.4 (s, 3H). m/z=482 (M +1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Application of 17289-20-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17289-20-2, name is Methyl 1-methyl-1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[2715] Dissolve 880 (1.4 g, 10 mol), CF3TMS (1.46 g, 10.25 mol), and CsF (15.2 mg, 0.1 mmol) in 15 ml THF. Stir at room temperature overnight, then concentrate under vacuum. Flash chromatograph the residue on silica gel using 0.5%-1% methanol in methylene chloride to obtain 933.

The synthetic route of Methyl 1-methyl-1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Reference of 172499-76-2, These common heterocyclic compound, 172499-76-2, name is Ethyl 3-(1H-imidazol-2-yl)propanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Difluoro-2-nitrobenzene 239 mg, ethyl 3-(1H-imidazol-2-yl)propanoate 252 mg, potassium carbonate 415 mg and N,N-dimethylacetamide 10 mL were heated at 100C for 64 hours. The reaction liquid was diluted with ethyl acetate and filtered. The filtrate was condensed under reduced pressure and subjected to silica gel chromatography (ethyl acetate) to provide 220 mg of the title compound. 1H-NMR(CDCl3, delta): 1.21(3H, t, J=7.3Hz), 2.6-3.0(4H, m), 4.08(2H, q, J=7.3Hz), 6.86(1H, d, J=1.5Hz), 7.08(1H, d, J=1.5Hz), 7.4-7.6(2H, m), 7.80(1H, dd, J=2.9, 7.5Hz). MS(m/z): 308(M++1), 187(base).

The synthetic route of 172499-76-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C5H6N2O

A solution of isopropylmagnesium chloride/lithium chloride complex (1.3 M in THF, 10.6 mL, 13.8 mmol) was added dropwise by syringe to a solution of 4-bromo-2-(trifluoromethyl)pyridine (3.12 g, 13.8 mmol) in dry THF (50 mL) at 0 C. After 30 min, a solution of 1-methyl-1H-imidazole-5-carbaldehyde in THF (1.38 g, 12.5 mmol) was added to the Grignard solution by syringe at 0 C. The reaction mixture was warmed to room temperature over 2 h after which it was quenched with saturated aqueous ammonium chloride solution. The mixture was partitioned between water and ethyl acetate. The separated aqueous phase was further extracted with ethyl acetate and washed with saturated aqueous NaCl solution. The organic phase was dried (MgSO4), filtered, and concentrated. The crude product was purified by flash column chromatography (silica gel, 0-10% MeOH-DCM) to provide the title compound.

The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1615-14-1, name is 2-(1H-Imidazol-1-yl)ethanol, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(1H-Imidazol-1-yl)ethanol

A 50-mL three-necked, round-bottomed flask, equipped with thermometer, nitrogen inlet, addition funnel, magnetic stirrer and reflux condenser was flame dried and flushed with nitrogen. The flask was charged with 25 ml_ of anhydrous dichloromethane. Freshly distilled 1-ethanol imidazole (1, 0.01 mol) was added into the flask. The flask was chilled with ice-water bath and /so-butyl iodide (0.011 mol) in 15 ml_ of anhydrous dichloromethane was added cautiously into the flask with continous stirring over 30 minutes. The solution was heated under reflux for 10 hours and then allowed to cool to room temperature. The dichloromethane solvent was distilled under to give 87% of 3-/so-butyl-1-ethanol imidazolium chloride 5.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 2466-76-4, These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

rac-3-acetyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (Starting Product for Example 19) A solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (2.5 mmol) in absolute THF (1 ml) was added at -78° C. to a freshly prepared solution of LDA (2.76 mmol) in absolute THF (2 ml) and was stirred at this temperature for 2 h. Then acetylimidazole (2.76 mmol) dissolved in THF (1.5 ml) was added dropwise and the reaction mixture was stirred overnight, with warming to room temperature. The addition of saturated ammonium chloride solution was followed by extraction three times with ether, the combined organic phases were washed with water and saturated sodium chloride solution, dried over sodium sulphate and the solvent was removed in a vacuum. After column chromatography purification on silica gel with hexane/EtOAc 5:1 the product is obtained as a yellow oil. tR 2.09; MS (neg. Ion.) m/z 240.41 [M-H]-. (J. Med. Chem. 1989, 32(2), 351-357).

The synthetic route of 2466-76-4 has been constantly updated, and we look forward to future research findings.

Application of 3034-50-2,Some common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1815] To a stirred solution of 4(5)-imidazolecarboxaldehyde (20.0 g, 0.208 mmol) in CH2Cl2 (200 mL), was added Et3N (29.0 mL, 0.208 mmol). The solution was then cooled down at 0 C., followed by addition of triphenylmethylchloride (52.8 g, 0.18 mmol) at 0 C. The resulting solution was stirred at room temperature overnight and then washed it with brine, water and concentrated to dryness to give a white solid (63.0 g, 98% yield, MH+=339.1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Imidazole-4-carbaldehyde, its application will become more common.

Electric Literature of 360-97-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 360-97-4, name is 4-Amino-1H-imidazole-5-carboxamide belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of 5-amino-1 H-imidazole-4-carboxamide (0.6 g, 4.7 mmol), toluene- 4-sulfonic acid butyl ester previously prepared (cf. Sekera, V. et al., “Higher alkyl sulfonates”, J. Am. Chem. Soalpha, 1993, vol. 55, p. 345) (1.3 g, 5.7 mmol), and Cs2CO3 (1.5 g, 4.7 mmol) in 25 ml_ of DMF was stirred at 8O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 5%) yielded delta-amino-i -butyl-I H-imidazole^-carboxamide (0.5 g, 62%) as a viscous oil . 1H-NMR [CDCI3, delta, ppm]: 8.1 (s, 1 H), 3.79 (m, 2H, CH2N), 1.54 (m, 2H, CH2), 1.37 (m, 2H, CH2), .0.92 (m, 3H, CH3).

The synthetic route of 4-Amino-1H-imidazole-5-carboxamide has been constantly updated, and we look forward to future research findings.