Category: 1003-21-0

Chen, Shuai; Graceffa, Russell F.; Boezio, Alessandro A. published the artcile< Direct, Regioselective N-Alkylation of 1,3-Azoles>, COA of Formula: C4H5BrN2, the main research area is regioselective alkylation azole purine organomagnesium reagent.

Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.

Organic Letters published new progress about Alkylation, regioselective. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Beckmann, Udo; Sueslueyan, Diyana; Kunz, PeterC. published the artcile< Is the 1JPSe Coupling Constant a Reliable Probe for the Basicity of Phosphines? A 31P NMR Study>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is coupling constant phosphine basicity probe.

The influence of different heteroaryl and functionalized aryl substituents on the electron-donating ability and basicity of the phosphorus atoms in heteroaryl phosphines and diphosphines has been determined by the use of the direct 1JPSe coupling constants of the corresponding selenides. The generality of the use of 31P-77Se spin-spin coupling constants as probe for the basicity of phosphines is discussed as well as the scope and limits of this concept.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Basicity (Broensted). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Holden, Kenneth G.; Mattson, Matthew N.; Cha, Kyung Hoi; Rapoport, Henry published the artcile< Synthesis of Chiral Pilocarpine Analogues via a C-8 Ketone Intermediate>, Name: 5-Bromo-1-methyl-1H-imidazole, the main research area is pilocarpine analog chiral synthesis; oxazolidinone analog pilocarpine stereoselective synthesis.

The synthesis of a chiral pilocarpine analog I in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alc. epimers and its reaction with a methylene ylide.

Journal of Organic Chemistry published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (imidazole-containing, oxazolidine analogs). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Name: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kummer, David A.; Cummings, Maxwell D.; Abad, Marta; Barbay, Joseph; Castro, Glenda; Wolin, Ronald; Kreutter, Kevin D.; Maharoof, Umar; Milligan, Cynthia; Nishimura, Rachel; Pierce, Joan; Schalk-Hihi, Celine; Spurlino, John; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Woods, Craig; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt>, Computed Properties of 1003-21-0, the main research area is quinoline tertiary alc preparation RORgammat antagonist inverse agonist; Agonist; IL-17; Inverse agonist; Neutral antagonist; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.

A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alc. hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design (structure-based). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Marshall, Checkers R.; Dvorak, Josh P.; Twight, Liam P.; Chen, Lan; Kadota, Kentaro; Andreeva, Anastasia B.; Overland, Alexandra E.; Ericson, Thomas; Cozzolino, Anthony F.; Brozek, Carl K. published the artcile< Size-Dependent Properties of Solution-Processable Conductive MOF Nanocrystals>, Computed Properties of 1003-21-0, the main research area is conductive iron triazolate MOF nanocrystal size property.

The diverse optical, magnetic, and electronic behaviors of most colloidal semiconductor nanocrystals emerge from materials with limited structural and elemental compositions Conductive metal-organic frameworks (MOFs) possess rich compositions with complex architectures but remain unexplored as nanocrystals, hindering their incorporation into scalable devices. Here, we report the controllable synthesis of conductive MOF nanoparticles based on Fe(1,2,3-triazolate)2. Sizes can be tuned to as small as 5.5 nm, ensuring indefinite colloidal stability. These solution-processable MOFs can be analyzed by solution-state spectroscopy and electrochem. and cast into conductive thin films with excellent uniformity. This unprecedented anal. of MOF materials reveals a strong size dependence in optical and electronic behaviors sensitive to the intrinsic porosity and guest-host interactions of MOFs. These results provide a radical departure from typical MOF characterization, enabling insights into phys. properties otherwise impossible with bulk analogs while offering a roadmap for the future of MOF nanoparticle synthesis and device fabrication.

Journal of the American Chemical Society published new progress about Absorptivity. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Taylor, Steven J.; Abeywardane, Asitha; Liang, Shuang; Muegge, Ingo; Padyana, Anil K.; Xiong, Zhaoming; Hill-Drzewi, Melissa; Farmer, Bennett; Li, Xiang; Collins, Brandon; Li, John Xiang; Heim-Riether, Alexander; Proudfoot, John; Zhang, Qiang; Goldberg, Daniel; Zuvela-Jelaska, Ljiljana; Zaher, Hani; Li, Jun; Farrow, Neil A. published the artcile< Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is indole derivative structure MMP 13 inhibitor arthritis.

Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a potent, selective MMP-13 inhibitor, developed using fragment-based structure-guided lead identification and optimization techniques. Virtual screening methods identified a novel, indole-based MMP-13 inhibitor that bound into the S1′ pocket of the protein exhibiting a novel interaction pattern hitherto not observed in MMP-13 inhibitors. X-ray crystallog. structures were used to guide the elaboration of the fragment, ultimately leading to a potent inhibitor that was >100-fold selective over nine other MMP isoforms tested.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kusama, Hitoshi; Arakawa, Hironori; Sugihara, Hideki published the artcile< Density functional study of imidazole-iodine interaction and its implication in dye-sensitized solar cell>, SDS of cas: 1003-21-0, the main research area is imidazole iodine interaction dye sensitized solar cell; charge transfer complex imidazole iodine density functional theory.

The monomer and charge-transfer complexes of 14 different imidazole derivatives with diiodine were studied by a d. functional theory (DFT) method. DFT calculations revealed that the σ* orbital of iodine interacts with the nitrogen lone pair of imidazoles at position 3. The influence of these imidazoles addition on the performance of a bis(tetrabutylammonium)cis-bis(thiocyanato)bis(2,2′-bipyridine-4-carboxylic acid, 4′-carboxylate)ruthenium(II) (N719) dye-sensitized nanocrystalline TiO2 solar cell with an I-/I3- redox electrolyte in acetonitrile was also studied. All of the imidazole derivatives enhanced the open-circuit photovoltage (Voc). The resulting Voc values of solar cell were compared to computational calculations on the interaction between imidazoles and I2 by a DFT method. Optimized geometries, frequency analyses, and interaction energies suggest that the V oc value is higher, the more the imidazole complexes with I2.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Bond angle. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, SDS of cas: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iddon, Brian; Lim, Bee Lan published the artcile< Metalation and metal-halogen exchange reactions of imidazoles>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is lithiation sulfuration ethoxymethylimidazole; imidazole lithiation sulfuration.

Imidazoles I (R = SPh, R1 = H, R2 = H, MeS) underwent lithiation and sulfuration to give thioimidazoles. E.g., I (R = SPh, R1 = R2 = H) was treated with BuLi in THF at -78° followed by addition of (PhS)2 to give I (R = R2 = SPh, R1 = H) quant. Similar treatment of I (R-R2 = Br) gave 67% I (R = SPh, R1 = R2 = Br).

Journal of the Chemical Society, Chemical Communications published new progress about Sulfuration. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

El Borai, M.; Moustafa, A. H.; Anwar, M.; Ghattas, A. G. published the artcile< Synthesis of new formyl halo N-methylimidazole derivatives>, Category: imidazoles-derivatives, the main research area is imidazole formylbromomethyl; methylimidazole formylation bromination.

Title compounds [I, R, R1, R2 = CHO, Br, H (II), Br, CHO, H; H, Br, CHO; CHO, H, Br; CHO, Br, Br] were prepared E. g., formylation of I (R = Br, R1 = R2 = H) followed by bromination gave II.

Croatica Chemica Acta published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Laviron, Etienne published the artcile< Polarographic and physicochemical study of pyridine derivatives and heterocyclic bases. III. Nitro, carbonyl, and halogen-containing derivatives of imidazole>, Quality Control of 1003-21-0, the main research area is .

Exptl. data from polarographic ultraviolet and spectrophotometric measurements showed that the 4 (or 5)-NO2 (or Br) derivative of imidazole exists almost totally as I (R =NO2 or Br) in solution

Bulletin de la Societe Chimique de France published new progress about Ionization. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem