Category: 1003-21-0

Bethel, Paul A.; Campbell, Andrew D.; Goldberg, Frederick W.; Kemmitt, Paul D.; Lamont, Gillian M.; Suleman, Abid published the artcile< Optimized scale up of 3-pyrimidinylpyrazolo[1,5-a]pyridine via Suzuki coupling; a general method of accessing a range of 3-(hetero)arylpyrazolo[1,5-a]pyridines>, Computed Properties of 1003-21-0, the main research area is Suzuki coupling pyrazolopyridine boronic ester; pyrazolopyridine heteroaryl aryl preparation.

We have developed an improved synthesis of 3-(hetero)aryl pyrazolo[1,5-a]pyridines [such as 3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (I)] via an optimized synthesis and Suzuki coupling of 3-pyrazolo[1,5-a]pyridine boronic ester (II). These conditions are applicable to both high throughput chem. and large scale synthesis of these medicinally important compounds The scope of this chem. has been further extended to include the synthesis and coupling of a novel boronic ester, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine.

Tetrahedron published new progress about Heterocyclic compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rizzo, Carla; Marullo, Salvatore; Feroci, Marta; Accurso, Vincenza; D’Anna, Francesca published the artcile< Insights into the effect of the spacer on the properties of imidazolium based AIE luminogens>, Category: imidazoles-derivatives, the main research area is imidazolium based aggregation induced emission luminogen preparation self assembly.

With the aim to obtain organic salts with potential applications in high performance mol. electronics, we combined properties of π-conjugated spacers, like 1,4-diethynylbenzene and 1,6-diethynylpyrene, with the ones of both imidazole and imidazolium units. Physico-chem. properties of obtained fluorescent organic salts were investigated performing thermo-gravimetric anal. (TGA), differential scanning calorimetry (DSC) and cyclic voltammetry measurements (CV). Photophys. behavior of the salts was analyzed in conventional solvents and ionic liquids, by UV-vis and fluorescence investigation. Solution phase aggregation study revealed that these salts self-assemble in conventional solvents and ionic liquids, leading to aggregation induced emission processes. Notably, emission was maintained also in the solid state, with higher or lower intensity compared with the solution, depending on which spacer is present. This latter, also impacts on the morphol. of the aggregates, allowing fine tuning the properties of the supramol. materials formed.

Dyes and Pigments published new progress about Aggregation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Grob, Jonathan E.; Nunez, Jill; Dechantsreiter, Michael A.; Hamann, Lawrence G. published the artcile< One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format>, Related Products of 1003-21-0, the main research area is arylmethylpyrrolidinylmethanol amine derivative preparation; aryl MIDA boronate preparation aryl halide amination Suzuki reaction; boronic acid MIDA.

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MIDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike mols.

Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ford, Jodi L; Browning, Christopher R published the artcile< Effects of exposure to violence with a weapon during adolescence on adult hypertension.>, HPLC of Formula: 1003-21-0, the main research area is Adverse childhood experiences; Exposure to violence; Hypertension; Victimization; Witnessed violence.

OBJECTIVES: To examine the longitudinal associations between exposure to violence with a weapon during the past year among adolescents and hypertension during adulthood, including the extent to which adult cardiovascular risk factors mediated the association. METHODS: Secondary analysis of the National Longitudinal Study of Adolescent Health, 1994-2008. The sample included 3555 male and 4416 female participants who were aged 11-17 years at wave 1 (1994-1995). Participants were categorized as hypertensive if they had a mean systolic blood pressure of 140 mm Hg or higher or a mean diastolic pressure of 90 mm Hg or higher at wave 4 (2008). Witnessed violence with a weapon was defined as having seen a shooting or stabbing during the year before wave 1, whereas victim of violence with a weapon was defined as having been shot, cut, or stabbed or had a gun or knife drawn on them during the year before wave 1. Potential mediators of adult cardiovascular risk (wave 4) included body mass index, daily smoking, alcohol abuse, and depression. RESULTS: Males who witnessed violence and females who were victims of violence in the year before wave 1 had an increased odds of hypertension at wave 4 compared with their unexposed peers (adjusted odds ratio, 1.45; 95% confidence interval, 1.003-2.10 and adjusted odds ratio, 1.72; 95% confidence interval, 1.04-2.84, respectively). The hypothesized adult cardiovascular risk mediators did not significantly attenuate the associations for either the male or female samples. CONCLUSIONS: Interventions addressing prior violence exposure are needed to promote adult cardiovascular health.

Annals of epidemiology published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alonso, Nerea; Munoz, Juan de M.; Egle, Brecht; Vrijdag, Johannes L.; De Borggraeve, Wim M.; de la Hoz, Antonio; Diaz-Ortiz, Angel; Alcazar, Jesus published the artcile< First example of a continuous-flow carbonylation reaction using aryl formates as CO precursors>, COA of Formula: C4H5BrN2, the main research area is haloarene aryl formate carbonylation flow chem.

The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives Further selective reduction of the ester formed to an aldehyde in flow is also described.

Journal of Flow Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas published the artcile< Novel Small Molecule Bradykinin B2 Receptor Antagonists>, Reference of 1003-21-0, the main research area is small mol bradykinin B2 receptor antagonist preparation structure.

Blockade of the bradykinin B2 receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B2 receptor antagonists with a mol. weight of approx. 500 g/mol. First, known quinoline-based B2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the min. pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B2 receptor. Optimization of the microsomal stability and cytochrome P 450 inhibition eventually led to the discovery of the highly potent and orally available B2 receptor antagonist 52e (JSM10292), which showed the best overall properties.

Journal of Medicinal Chemistry published new progress about Angioedema. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Reference of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manasieva, Leda Ivanova; Maria, Battisti Umberto; Prandi, Adolfo; Brasili, Livio; Franchini, Silvia published the artcile< Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is heteroaryl ortho phenoxyethylamine preparation Suzuki cross coupling.

Heteroaryl ortho-phenoxyethylamines have been extensively employed in medicinal chem. as privileged scaffolds for the design of highly potent and selective ligands. Herein an efficient, fast, and general method for the synthesis of heteroaryl phenoxyethylamines via Suzuki cross-coupling is reported. This approach offers the opportunity to obtain a large variety of biaryls incorporating five-membered (thiophene, furan, thiazole, pyrazole, imidazole) or six-membered (pyridine, pyrimidine) heteroaromatic rings for appropriate libraries of ligands. All the compounds presented here have never been synthesized before and a full structural characterization is given.

Synthesis published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (phenoxyethylamines). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ohba, Masashi; Mukaihira, Takafumi; Fujii, Tozo published the artcile< Synthesis of 5-arylthio-3-methyl-L-histidine, a model for the starfish alkaloid imbricatine>, Electric Literature of 1003-21-0, the main research area is histidine arylthiomethyl; imbricatine model synthesis.

Syntheses of 3-methyl-5-phenylthio-L-histidine (I, R = Ph) and 3-methyl-5-(1-naphthyl)thio-L-histidine ( R = 1-naphthyl), selected as models for the asteroid alkaloid imbricatine (II), have now become feasible through a 10-step route starting from 4(5)-bromoimidazole. The key steps involve replacement of the 4-bromo group by an arylthio group in the aldehyde III and construction of the L-alanine moiety in the chlorides IV by the “”bis-lactim ether”” method.

Heterocycles published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Electric Literature of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre published the artcile< Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3>, Category: imidazoles-derivatives, the main research area is pyridinylimidazole preparation JNK3 inhibitor p38alpha MAP kinase.

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog.

ACS Omega published new progress about Bioactive lead compounds. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Yi; Zhou, Cuihan; Jiang, Meijing; Arndtsen, Bruce A. published the artcile< Versatile Palladium-Catalyzed Approach to Acyl Fluorides and Carbonylations by Combining Visible Light- and Ligand-Driven Operations>, Formula: C4H5BrN2, the main research area is acyl fluoride preparation; acyl halide carbon monoxide photochem carbonylation palladium catalyst.

The development of a general palladium-catalyzed carbonylative method to synthesize acyl fluorides RC(O)F (R = n-Bu, cyclohexyl, 4-methylphenyl, pyridin-3-yl, etc.) from aryl, heteroaryl, alkyl, and functionalized organic halides RX was described. Mechanistic anal. suggests that the reaction proceeds via the unique, synergistic combination of visible light photoexcitation of Pd(0) to induce oxidative addition with a ligand-favored reductive elimination. These together create a unidirectional catalytic cycle that is uninhibited by the classical effect of carbon monoxide coordination. Coupling the catalytic formation of acyl fluorides with their subsequent nucleophilic reactions has opened a method to perform carbonylation reactions with unprecedented breadth, including the assembly of highly functionalized carbonyl-containing products.

Journal of the American Chemical Society published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem