Category: 14700-62-0

Application of 14700-62-0, A common heterocyclic compound, 14700-62-0, name is 2-Benzyl-1H-imidazole, molecular formula is C10H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

13. 4-(2-Benzylimidazol-1-yl)benzyl alcohol Prepared from 2-benzylimidazol and ethyl 4-fluorobenzoate. MW: 264.33 1 H NMR (CDCl3) delta:7.45-7.37(m, 2H), 7.28-7.10(m, 8H), 7.00(d, J=1.5 Hz, 1H), 4.77(d, J=4.0 Hz, 2H), 4.02(s, 2H), 2.20-2.07(br, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Pfizer Inc.; US5753682; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 14700-62-0, name is 2-Benzyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14700-62-0, Recommanded Product: 2-Benzyl-1H-imidazole

a) N,N-dimethylformamide (200 ml) was stirred at room temperature under nitrogen and a dispersion sodium hydride 50% in mineral oil (0.113 mol) was added portionwise. 2-Phenylmethyl-1H-imidazole (0.075 mol) was added portionwise and the mixture was stirred for 1 hour at room temperature. Ethyl chloroacetate (0.113 mol) dissolved in N,N-dimethylformamide was added dropwise and the mixture was stirred at room temperature for 30 minutes. The mixture was poured into a NaHCO3 solution and extracted with dichloromethane. The organic layer was dried (MgSO4), filtered off and evaporated. The residue was purified on a glass filter over silica gel (eluent: CH2 Cl2 /CH3 OH 95/5). The pure fractions were collected and evaporated, yielding 16 g (93%) of product. A sample (1 g) was crystallized from 2,2′-oxybispropane/acetonitrile, yielding 0.58 g of methyl 2-(phenylmethyl)-1H-imidazole-1-acetate; mp. 70.8 C. (interm. 21). A mixture of intermediate (21) (0.017 mol) in trifluoromethanesulfonic acid (25 ml) was stirred at 140 C. overnight. The mixture was cooled, poured into a K2 CO3 solution/ice water and extracted with dichloromethane/ethanol.

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Reference:
Patent; Janssen Pharmaceutica N.V.; US5674866; (1997); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem