Category: 2403-66-9

《Synthesis and the reactions of 2,4,6-tris(ω-hydroxyalkyl)-1,3,5triazines》 was published in Bulletin of the Chemical Society of Japan in 1965. These research results belong to Nohira, Hiroyuki; Nishikawa, Yoshihiro; Furuya, Yoshiaki; Mukaiyama, Teruaki. Product Details of 2403-66-9 The article mentions the following:

From HO(CH2)nCN (I) and HCl were prepared the corresponding cyclic imino ethers HCl salts (II.HCl), which on treatment with Et3N gave the title compounds (III). The reactions of III with o-C6H4-(NH2)2 (IV) and 1,8-naphthalenediamine (V) were investigated. Treatment of Cl(CH2)3OH with KCN in EtOH-H2O (Aksnes and Prue, CA 53, 8004f) gave 30% I (n = 3), b11 1078°. A mixture of 22 g. Cl(CH2)4OH, 33 g. KCN, 50 ml. glycerol, and 25 ml. H2O heated and stirred 15 min. at 100-10°, cooled, and extracted with 4 50-ml. portions tetrahydrofuran (THF) gave 7.0 g. I (n = 4), b0.5 86-8°; when the distillation was carried out without extracting soon after the reaction was complete, almost 30% THF, b. 65-6° was formed as by-product. From Cl(CH2)5OH was similarly prepared 83% I (n = 5), b3 97-8°. Dry HCl passed into 300 ml. dry Et2O containing 8.5 g. I (n = 3) at 10-15° with cooling and the mixture let stand 2 days at room temperature in a stoppered flask gave 11.5 g. II (n = 3) HCl salt, m. 103-5°. Similar treatment of I (n = 4) with HCl but in more dilute (1.5-2.0%) Et2O solution gave 90% II (n = 4) HCl salt, m. 128-9°. Dry HCl passed into 150 ml. dry Et2O and 80 ml. dry glycol acetal-free dioxane containing 4.5 g. I (n = 5) with cooling and the mixture kept 4 days at room temperature, refluxed 3 hrs., and evaporated in vacuo gave 5.1 g. H (n = 5) HCl salt, m. 143-4°. Heating II.HCl 5 min. at 150-60° or refluxing them in PhMe gave the corresponding Cl(CH2)nCONH2 (VI). The following VI were prepared (n, % yield, and m.p. given): 3, 95, 97°; 4, 80, 78°; 5, 95, 102°. II.HCl (0.08 mole) and 16.0 g. Et3N in 80 ml. absolute THF let stand 3 days at room temperature in a stoppered flask with intermittent shaking and the solution filtered and fractionated gave the following III (n, % yield, and b.p./ mm. given): 3, 53, 196-8°/0.1; 4, 70, 207-9°/0.04; 5, 50, 21821°/0.01. III (n = 3) (0.5 g.) and 0.7 g. PhNCO in 10 ml. THF let stand 2 days and evaporated gave 1.1 g. VII, m. 124-5° (95% EtOH). III and 3 mol. equivalents IV or V heated at 220-30° (oil bath) under N evolution of NH3 ceased (15-60 min.) and the mixture cooled and washed with Et2O gave VIII and IX, resp. The following VIII and IX were prepared (n, % yield, and m.p. given): VIII: 3, 85, 160-1° (THF) (O-Ac derivative m. 88-9°); 4, 79, 1645° (THF) (O-Ac derivative m. 95-7°; O,N-di-Ac deriv, m. 68-9°); 5, 55, 106° (EtOAc) (O,N-di-Ac derivative m. 78-9°); IX: 3, 34, 145-6° (dioxane); 4, 45, 157-8° (THF); 5, 60, 185-7° (dioxane). The O-Ac derivatives of VIII were prepared by reaction of VIII and 1.2 mol. equivalents Ac2O in C2H5N at room temperature; the O,N-di-Ac derivatives of VIII were prepared by reaction of VIII and 2.5 mol. equivalents Ac2O in C5H5N at 100% III (n = 3) (0.5 g.) and 0.7 g. V heated 1 hr. at 250-60° (N atm.) and the mixture cooled and washed with Et2O gave 0.5 g. X, m. 143-4° (THF). Ir and uv data were given for III (n = 3, 4, and 5). The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Product Details of 2403-66-9)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Product Details of 2403-66-9 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

SDS of cas: 2403-66-9On March 31, 1987, Hasan, Mashooda; Latif, Farzana; Garcia Alvarez, Maria C. published an article in Journal of the Chemical Society of Pakistan. The article was 《Preparation, physical properties and nuclear magnetic resonance spectral studies of isomeric 2-(hydroxypropyl)benzimidazoles》. The article mentions the following:

Preparation, phys. properties and NMR spectral (1H and 13C) data of 2-[2-(hydroxypropyl)]- and 2-[3-(hydroxypropyl)]benzimidazoles and have been described. In the experiment, the researchers used many compounds, for example, 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9SDS of cas: 2403-66-9)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. SDS of cas: 2403-66-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C10H12N2OOn October 20, 2010 ,《Tetra butyl ammonium chloride catalyzed synthesis of substituted benzimidazoles under microwave conditions》 was published in Journal of the Korean Chemical Society. The article was written by Karuvalam, Ranjith. P.; Siji, M.; Divia., N.; Haridas, Karickal. R.. The article contains the following contents:

Tetrabutylammonium chloride (10 mol%) was a useful catalyst for the synthesis of substituted benzimidazoles from o-phenylenediamines with benzoic acids. The method was simple, convenient and the product was isolated with good yield. In addition to this study using 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol, there are many other studies that have used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Electric Literature of C10H12N2O) was used in this study.

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Electric Literature of C10H12N2O Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Karuvalam, Ranjith P.; Haridas, Karickal R.; Shetty, Suchetha N. published an article in Journal of the Chilean Chemical Society. The title of the article was 《Trimethylsilyl chloride-catalyzed synthesis of substituted benzimidazoles using two phase system under microwave conditions, and their antimicrobial studies》.Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The author mentioned the following in the article:

A convenient method using Me3SiCl (20 mol %) and microwave-induced technique for the synthesis of various benzimidazole is described. This reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Some of the compounds indicated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds exhibited activity at MIC of 6.25 μg/mL. In the experiment, the researchers used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Elmali, A.; Elerman, Y.; Eren, G.; Guemues, F.; Svoboda, I. published an article on February 28 ,2005. The article was titled 《The crystal structures of 2-(3′-hydroxypropyl)benzimidazolium hexa- and tetrachloroplatinate》, and you may find the article in Zeitschrift fuer Naturforschung, B: Chemical Sciences.Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The information in the text is summarized as follows:

2-(3′-Hydroxypropyl)benzimidazolium (Hhpb) hexa- and tetrachloroplatinate (Co10H13N2O)2·[PtCl6] (I) and (C10H13N2O)2·[PtCl4] (II) were synthesized and their crystal structures determined I is monoclinic, space group P21/n, a 8.800(1), b 14.389(2), c 10.264(2) Å, β 98.540(10)°, and Z = 2. II is triclinic, space group P1̅, a 7.8480(10), b 9.0460(10), c 9.6980(10) Å, α 65.420(10), β 68.810(10), γ 76.770(1)°, and Z = 1. In both compounds, the Pt atoms reside at a center of inversion. I and II are comprised of 2-(3′-hydroxypropyl)benzimidazolium (Hhpb)+:(C10H12N2O)+ and [PtCl6]2- and [PtCl4]2- ions, resp., linked by intermol. H bonds N···Cl [range from 3.428(3) to 3.584(4) Å], N···O [2.769(5) Å] and O···Cl [3.338(4) and 3.321(3) Å] for I, and N···Cl [3.162(7) Å], N···O [2.749(8) Å] and O···Cl [3.289(6) Å] for II. The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Reactions of lead tetraacetate. VII. Some reactions leading to pyrazoles》 was published in Journal of the Chemical Society [Section] C: Organic in 1966. These research results belong to Gladstone, W. A. F.; Norman, R. O. C.. Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The article mentions the following:

cf. preceding abstract Four 2-pyrazolines were oxidized to the corresponding pyrazoles in high yields by Pb(OAc)4 at room temperature: this reagent has advantages over others which have been used previously. Pb(OAc)4 converts chalcone phenylhydrazone directly into 1,3,5-triphenylpyrazole, in contrast to its reactions with the arylhydrazones of aromatic ketones which give azoacetares. Two 2-pyrazolines which cannot undergo direct aromatization have been converted into pyrazoles by oxidation with Pb(OAc)4 to 4-acetoxy-2-pyrazolines followed by acid-catalyzed rearrangement and elimination. 19 references. In the experimental materials used by the author, we found 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 2403-66-9On March 15, 2004, Kusama, Hitoshi; Arakawa, Hironori published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The article was 《Influence of benzimidazole additives in electrolytic solution on dye-sensitized solar cell performance》. The article mentions the following:

The influence of benzimidazole additives on the performance of a bis(tetrabutylammonium)-cis-bis(thiocyanato)bis(2,2′-bipyridine-4-carboxylic acid, 4′-carboxylate)ruthenium(II) dye-sensitized TiO2 solar cell with an I-/I3- redox electrolyte in acetonitrile was studied by measuring the current-voltage characteristics of >20 different benzimidazole derivatives under AM 1.5 (100 mW/cm2). The benzimidazole additives tested had varying effects on the cell performance. Adding benzimidazole drastically enhanced the open-circuit photovoltage (Voc) and the fill factor (ff), but reduced the short-circuit photocurrent d. (Jsc) of the solar cell. To determine the reasons for the additive effects on cell performance the phys. and chem. properties of the benzimidazoles were computationally calculated Consequently, the greater the calculated partial charge of the nitrogen atoms in position 3 of the benzimidazole groups, the larger the Voc, but the smaller the Jsc values. The Voc values also increased as the mol. size of the benzimidazole derivatives decreased. Also, the greater the absolute difference between the calculated dipole moment of the benzimidazole and acetonitrile, the larger the Jsc value. Probably these properties of the benzimidazoles influenced the extent of interaction between the TiO2 electrode and electrolyte solvent, which changed the dye-sensitized solar cell performance. In the experiment, the researchers used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9HPLC of Formula: 2403-66-9)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
HPLC of Formula: 2403-66-9 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rakhmonova, Dilnoza; Kadirova, Zukhra; Torambetov, Batirbay; Kadirova, Shakhnoza; Ashurov, Jamshid; Shishkina, Svitlana published an article in Acta Crystallographica, Section E: Crystallographic Communications. The title of the article was 《The molecular and crystal structures of 2-(3-hydroxypropyl)benzimidazole and its nitrate salt》.Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The author mentioned the following in the article:

2-(3-Hydroxypropyl)-1H-benzimidazole, C10H12N2O, which has potential biol. activity, can be used as a ligand for complexation with metals. This compound is an electron donor, due to the lone pair of the nitrogen atom in the imidazole ring. This nitrogen atom also acts as a proton acceptor. In the crystalline phase, the nitrate salt, namely, 2-(3-hydroxypropyl)-1H-benzimidazol-3-ium nitrate, C10H13N2O+·NO3-, has been studied. The protonation of the 2-(3-hydroxypropyl)benzimidazole unit results in significant delocalization of the electron d. within the imidazole ring. The salt formation leads to variations in the intermol. interactions, which were studied by anal. of the Hirshfeld surfaces and two-dimensional fingerprint plots.3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol) was used in this study.

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem