250285-32-6 Archives - Page 5 of 11 - Imidazoles-derivatives

Saab, Marina team published research in Dalton Transactions in | 250285-32-6

Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Saab, Marina;Nelson, David J.;Tzouras, Nikolaos V.;A. C. A. Bayrakdar, Tahani;Nolan, Steven P.;Nahra, Fady;Van Hecke, Kristof research published 《 Straightforward access to chalcogenoureas derived from N-heterocyclic carbenes and their coordination chemistry》, the research content is summarized as follows. Chalcogen-based urea compounds supported by a wide range of N-heterocyclic carbenes were synthesized and fully characterized. Coordination of selenoureas is further explored with Group 11 transition metals to form new copper, gold and silver complexes. Single crystal x-ray analyses unambiguously establish the solid-state coordination of these complexes and show that the geometry of a complex is highly influenced by a combination of electronic properties – mainly π-accepting ability – and steric hindrance of the ligands, as well as the nature of the metal, affording a variety of coordination behaviors. The authors study these phenomena using several exptl. methods.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pein, Wesley L. team published research in Organic Letters in 2021 | 250285-32-6

Computed Properties of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Computed Properties of 250285-32-6.

Pein, Wesley L.;Wiensch, Eric M.;Montgomery, John research published 《 Nickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation》, the research content is summarized as follows. The conversion of silyloxyarenes to boronic acid pinacol esters via Ni catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the C-O bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Piontek, Aleksandra team published research in ChemCatChem in 2021 | 250285-32-6

Application In Synthesis of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Piontek, Aleksandra;Ochedzan-Siodlak, Wioletta;Bisz, Elwira;Szostak, Michal research published 《 Cobalt-NHC Catalyzed C(sp²)-C(sp³) and C(sp²)-C(sp²) Kumada Cross-Coupling of Aryl Tosylates with Alkyl and Aryl Grignard Reagents》, the research content is summarized as follows. The first cobalt-catalyzed cross-coupling of aryl tosylates with alkyl and aryl Grignard reagents were reported. The catalytic system used CoF₃ and NHC (NHC=N-heterocyclic carbene) as ancillary ligands. The reaction proceeded via highly selective C-O bond functionalization, which leaded to the corresponding products in up to 98% yield. The employment of alkyl Grignard reagents allows to achieve a rare C(sp₂)-C(sp₃) cross-coupling of C-O electrophiles, circumvented isomerization and β-hydride elimination problems. The use of aryl Grignards resulted in formation of biaryls. The C-O cross-coupling sets the stage for a sequential cross-coupling by exploiting the orthogonal selectivity of the catalytic system.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco team published research in ACS Sustainable Chemistry & Engineering in 2021 | 250285-32-6

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Application of C27H37ClN2.

Pisano, Gianmarco;Cazin, Catherine S. J. research published 《 General Mechanochemical Synthetic Protocol to Late Transition Metal-NHC (N-Heterocyclic Carbene) Complexes》, the research content is summarized as follows. A user-friendly and highly efficient mechanochem. strategy for the synthesis of a number of well-defined, catalytically relevant N-heterocyclic carbene-metal complexes under aerobic conditions is reported. This protocol proceeds in good to excellent yields and limits solvent usage to the purification step, which can be carried out, after judicious selection, using minimal amounts of environmentally benign solvents.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco team published research in Green Chemistry in 2020 | 250285-32-6

HPLC of Formula: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Pisano, Gianmarco;Cazin, Catherine S. J. research published 《 Mechanochemical synthesis of Cu(I)-N-heterocyclic carbene complexes》, the research content is summarized as follows. It is reported a general, operationally simple and scalable mechanochem. method for the synthesis of [Cu(Cl)(NHC)] complexes. This solid-state and solvent-less methodol. was shown to be applicable to a wide range of NHC ligand precursors, allowing access to complexes of the type [Cu(Cl)(NHC)] under aerobic conditions and with minimised environmental impact.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prima, Darya O. team published research in Catalysis Science & Technology in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Prima, Darya O.;Madiyeva, Malena;Burykina, Julia V.;Minyaev, Mikhail E.;Boiko, Daniil A.;Ananikov, Valentine P. research published 《 Evidence for “cocktail”-type catalysis in Buchwald-Hartwig reaction. A mechanistic study》, the research content is summarized as follows. The mechanism of the C-N cross-coupling reaction, catalyzed by palladium complexes with N-heterocyclic carbene ligands (Pd/NHC), was evaluated in detail at the mol. and nanoscale levels. For the first time, the formation of a “cocktail”-type catalytic system was proven for the Buchwald-Hartwig reaction. The unique ability of the Pd/NHC system to generate several types of catalytic centers (Pd complexes, clusters and nanoparticles) and the involvement of complementary pathways (homogeneous and heterogeneous) were discovered to take place in a “one pot” manner directly in the reaction vessel. Access to various catalytic centers from a single and readily available Pd/NHC complex is the key to designing a universal catalytic system with adaptive tuning capability.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ng, Shan Shan team published research in Advanced Synthesis & Catalysis in 2022 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Ng, Shan Shan;Chen, Zicong;Yuen, On Ying;So, Chau Ming research published 《 Palladium-Catalyzed Chemoselective Borylation of (Poly)halogenated Aryl Triflates and Their Application in Consecutive Reactions》, the research content is summarized as follows. Chemoselective palladium-phosphine-catalyzed borylation of halogenated aryl triflates TfOC₆H_nY_4-nX (X = Cl, Br; Y = H, OMe, F, Me, PhCH₂, aryl, CN) gave boryl triflates TfOC₆H_nY_4-nBpin, which can be applied for Suzuki coupling with aryl chlorides in one-pot two-step procedure, giving functionalized biaryls. This study reports the palladium-catalyzed chemoselective borylation of (poly)halogenated aryl triflates with a reactivity order of C-Cl>C-OTf. A catalyst system comprising Pd(OAc)₂ and SelectPhos (L1) enables a reaction with high reactivity and chemoselectivity. The consecutively chemoselective borylation reaction followed by the chemoselective intermol. Suzuki-Miyaura reaction can be performed using a one-pot two-step approach to synthesize unsym. biaryl compounds containing the triflate moiety. The reaction can be scaled up to the gram scale without diminishing the yield and chemoselectivity.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Obst, Marc F. team published research in Organometallics in 2020 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Obst, Marc F.;Gevorgyan, Ashot;Bayer, Annette;Hopmann, Kathrin H. research published 《 Mechanistic Insights into Copper-Catalyzed Carboxylations》, the research content is summarized as follows. The Cu-NHC-catalyzed carboxylation of organoboranes with CO₂ was studied using computational and exptl. methods. The DFT and DLPNO-CCSD(T) results indicate that nonbenzylic substrates are converted via an inner-sphere carboxylation of an organocopper intermediate, whereas benzylic substrates may simultaneously proceed along both inner- and outer-sphere CO₂ insertion pathways. The computations predict that two conceptually different carboxylation mechanisms are possible for benzylic organoboranes, one being Cu-catalyzed and one being mediated by the reaction additive CsF. The authors’ exptl. evaluation of the computed reactions confirms that carboxylation of nonbenzylic substrates requires Cu catalysis, whereas benzylic substrates can be carboxylated with and without Cu.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oliveira, Joao C. A. team published research in ACS Catalysis in 2021 | 250285-32-6

COA of Formula: C27H37ClN2, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. COA of Formula: C27H37ClN2.

Oliveira, Joao C. A.;Dhawa, Uttam;Ackermann, Lutz research published 《 Insights into the Mechanism of Low-Valent Cobalt-Catalyzed C-H Activation》, the research content is summarized as follows. The use of cobalt complexes of N-heterocycle carbene (NHC) ligands as catalysts for C-H activation is extremely advantageous due to their low costs and high efficiencies at room temperature These catalysts have been proposed to operate in low oxidation states and have successfully been applied in C-H alkylations as well as C-H arylations, among others. Despite these indisputable advances, detailed mechanistic insights into their exact working mode continue to be scarce. Herein, we present extensive DFT and DLPNO-CCSD(T) computational studies, which provide strong support for a mechanism via low-valent cobalt-catalyzed C-H activations. Our findings indicate the key C-H metalation to proceed through a ligand-to-ligand hydrogen transfer (LLHT) pathway rather than a classical oxidative addition mechanism.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mazars, Francois team published research in European Journal of Organic Chemistry in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Application of C27H37ClN2.

Mazars, Francois;Hrubaru, Madalina;Tumanov, Nikolay;Wouters, Johan;Delaude, Lionel research published 《 Synthesis of Azolium-2-dithiocarboxylate Zwitterions under Mild, Aerobic Conditions》, the research content is summarized as follows. Twelve imidazolium-, imidazolinium-, or benzimidazolium-2-dithiocarboxylate zwitterions with aliphatic or aromatic substituents on their nitrogen atoms, including four new unsym. 1-alkyl-3-arylimidazolium derivatives, were obtained in high yields (62-96%) upon reaction of azolium salts with CS₂ and Cs₂CO₃ in acetonitrile at room temperature Compared to the previous strategies devised for the synthesis of NHC·CS₂ betaines, this novel procedure relied on an innocuous, weak base and could be applied under mild aerobic conditions. All the new compounds were fully characterized by various anal. techniques and the mol. structures of two of them were determined by XRD anal. An associative mechanism involving the concerted reaction of the azolium salts with both CS₂ and CO₃^2- was tentatively proposed to account for the formation of the zwitterionic adducts without the intervention of free carbenes. This would explain the good results obtained with a weak inorganic base that lacks the strength needed to deprotonate the azolium salt substrates.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem