Category: 288-32-4

Adding a certain compound to certain chemical reactions, such as: 288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-32-4, Recommanded Product: 288-32-4

Example L Procedure for the synthesis of [L-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL IMIDAZOLE] (Formula 13) N CISO2NMe2 N 1) n-BuLi.-78C N/ C Si – N”N’N H Et3N, benzene % 2) TBDMSCI S02NMe2 S02NMe2 Intermediate L1 Intermediate L2 Formula 13 Imidazole (Intermediate [LL,] available from Aldrich, 20.0 g, 0.29 mol), triethylamine [(41.] 0 mL, 0.29 mol) [AND N, N DIMETHYLSULFAMOYL] chloride (31.6 [ML,] 0.29 mol) were added to benzene (320 mL). The reaction was stirred for 48h at rt and then filtered. The filtrate was collected and concentrated under reduced pressure. Vacuum distillation of the crude produc (-0. 5 [MMHG,] [115-118 C)] afforded dimethylsulfamoyl) imidazole (Intermediate L2) 38.7 g (76%) as a clear and colorless oil. Upon cooling the product solidifies to give white crystals. 1- (Dimethylsulfamoyl) imidazole (Intermediate L2) (18.8 g, 0.11 mol) was added to THF (430 mL). The solution was cooled [TO-78 C.] A solution of n-BuLi (70.9 [ML,] 1.6 M in hexane) was added dropwise to the reaction mixture. Upon completion, the solution was stirred for lh [AT-78 C. T-BUTYLDIMETHYLSILYLCHLORIDE (TBSC1)] (17.8 g, [0. 12] mol) in THF (50 [ML)] was added via cannula to the mixture. After the addition was completed the reaction mixture was warmed slowly to rt and stirred for 24h. The mixture was diluted with water and the organic layer separated. The organic phase was washed with brine and then dried over [NA2S04.] The mixture was filtered and the filtrate concentrated under reduced pressure. Column chromatography on [SI02] with 20% ethyl acetate/hexane afforded [1-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL] imidazole (Formula 13) as a light yellow solid. Recrystallization from pentane gave 30 g (94%) of white crystals.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

Imidazole (10 g, 0.150 mol) and sodium hydroxide (29.4 g, 0.74 mol) were charged to the reaction flask containing water (250 mL) and stirred vigorously for 15 min at ambient temperature. Cooled the reaction mass to 10 C and charged sodium hypochlorite (16.7 g, 0.225 mol) to the reaction mixture, during the addition temperature was maintained at 10 C. Stirred the reaction mass for 6 h at ambient temperature, the reaction completion was monitored by TLC. After the completion of the reaction cooled the reaction mass to 10 C and slowly charged concentrated HCl solution to bring the reaction pH to 6 to 7. Charged dichloromethane (2 * 200 mL) and stirred for 10 min, separated the organic layer and was washed with saturated brine solution. The organic layer was dried over sodium sulfate and concentrated the dichloromethane and the crude obtained was purified by column chromatography on a silica gel (230-400 mesh) using ethyl acetate (10-35%) in petroleum ether as eluant to afford 4-chloroimidazole. Appearance: Pale yellow solid; Yield = 52%; M.P. = 118-119 C; 1H NMR (400 MHz, DMSO-d6) delta ppm = 7.09 (s, 1H, ArH), 7.39 (s, 1H, ArH), 12.42 (s, 1H, NH); 13C NMR (300 MHz, DMSO-d6) delta ppm = 126.7, 128.2, 140.2; LC/MS (ESI-MS) m/z = 103.6 (M + 1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

General procedure: To a solution of 1 (0.02 mmol) in H2O/MeCN (v/v=2/1, 4 mL) was added 1H-imidazole (1.0 mmol) and arylboronic acid (2 mmol)under O2 atmosphere. The mixture was stirred at 60 C for 24 h. After cooling to ambient temperature, the mixture was partitioned between water and CH2Cl2. The organic layer was separated, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1H-Imidazole

General procedure: A solution of imidazole 3 (30 mmol) in THF (60 mL) was treated with NaOH (25 mL, 40% aq) and the alkyl bromide (30 mmol), and the reaction was refluxed overnight. The solvent was evaporated and the crude reaction mixture was extracted with CH2Cl2 against water. The organic layer was washed with water, dried over MgSO4 and concentrated. The final product was distilled under vacuum (~5 mbar) to provide 4 as yellow oily liquid in 80-85% yield.

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

Reference Example 2 1.3 g of sodium hydride (60%) was added to 10 ml of tetrahydrofuran, and a solution of 2.0 g of imidazole in 10 ml of tetrahydrofuran was added dropwise to the resulting suspension. After 2 hours of stirring at 0 C., the solution was mixed with 1.86 ml of chloroacetonitrile and stirred at room temperature for 3 hours. To the reaction solution was added water and chloroform, and the organic layer was collected and dried over anhydrous sodium sulfate, followed by evaporation of the solvent. The residue was subjected to alumina column chromatography eluted with dichloromethane-methanol (200:1) to obtain 1.043 g of 1-cyanomethylimidazole. Mass spectrometry value (m/z): 107 (M+ +1) Nuclear magnetic resonance spectrum (CDCl 3, TMS internal standard) delta: 4.95 (2H, s), 7.06 (1H, d), 7.09 (1H, d), 7.57 (1H, s)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5565479; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a document, author is Mao, Pu, introduce the new discover, Quality Control of 1H-Imidazole.

Synthesis of Novel Chiral Thioether Ligands Containing Imidazole Rings Based on Natural Amino Acids

Using commercially available natural amino acids (L-Val, L-Leu, L-Phe) as chiral precursors, a series of N-substituted imidazole derivatives containing chiral groups was synthesized from the condensation reaction of amino acids, formaldehyde, glyoxal, and ammonia. Through esterification, reduction, chlorination, and subsequent substitution by thiols, chiral thioethers containing imidazole rings were synthesized, and the synthetic conditions were optimized. All the intermediates and the final products were characterized by NMR, ESI MS, HR MS, and IR.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 288-32-4 is helpful to your research. Quality Control of 1H-Imidazole.

Related Products of 288-32-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Grishchenko, Lyudmila A., introduce new discover of the category.

Arabinogalactan propargyl ethers: Au-catalysed hydroamination by imidazols

A method for the synthesis of pharmacologically prospective arabinogalactan (AG) imidazole- and benzimidazole derivatives in a yield of up to 97 % via Au(III)-catalyzed hydroamination of AG propargyl ethers has been developed. It is found that in the presence of 5 mol% HAuCl4 and 10-fold excess imidazole relative to the propargyl groups, the hydroamination successfully competes with cross-linking processes to afford products soluble in DMSO and aqueous HCl solutions (degree of substitution of imidazolylpropenyl fragments 0.5-1.8, yield 62-97 %). It is established that under the conditions of hydroamination Au(III) is reduced to give mainly Au(0) and minor amounts of Au(I), which are contained in AG imidazole derivatives as particles of 190-640 nm in size. Hydrochlorides of Au-containing AG imidazole derivatives show high bacteriostatic activity with respect to test gram-positive microorganisms and thus confirming their prospects as new AG-derived bioactive agents.

Related Products of 288-32-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 288-32-4 is helpful to your research.

Reference of 288-32-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Zhang, PF, introduce new discover of the category.

Hypervalent iodine in synthesis 81: A one-pot procedure for the synthesis of 1H-imidazole derivatives by cyclocondensation of ketones with [hydroxy(tosyloxy)iodo]benzene and amidines

Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by treatment with amidines provides a one-pot procedure for the synthesis of 1H-imidazole derivatives with good yields.

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Application of 288-32-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Bansal, Ravi, introduce new discover of the category.

Green Synthesis of 1,2,4,5-Tetrasubstituted and 2,4,5-Trisubstituted Imidazole Derivatives Involving One-pot Multicomponent Reaction

Sodium lauryl sulfate has been found convenient, versatile, and eco-friendly catalyst for the synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazole derivatives by one-pot multicomponent reactions at 80 degrees C using water as solvent. This protocol afforded advantages, that is, the metal-free reaction, purification of products by non-chromatographic method, and excellent yields.

Application of 288-32-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 288-32-4 is helpful to your research.

Application of 288-32-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Gerber, TIA, introduce new discover of the category.

Synthesis and structural characterization of cationic octahedral oxorhenium(V) complexes with bidentate imidazole derivatives

Cationic distorted octahedral complexes [ReOCl(OEt)(L)(PPh3)]X {L=2-(1-ethylaminomethyl)-1-methylimidazole (eami), 2-(1-methylaminomethyl)-1-methylimidazole (mami), 2-(1-ethylthiomethyl)-1-methylimidazole (etmi); X=ReO4, PF6} were prepared by reaction of trans-[ReOCl3(PPh3)(2)] with a twofold molar excess of L in ethanol under anaerobic conditions. X-ray structure determinations of [ReOCl(OEt)(eami)(PPh3)](ReO4) (1a) and its etmi equivalent (3a) were performed. In la coordination of the chloride occurs trans to the imidazole nitrogen. However, in 3a the chloride is coordinated trans to the ethereal sulfur donor of etmi.

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