Category: 288-32-4

Related Products of 288-32-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is IRADYAN, MA, introduce new discover of the category.

IMIDAZOLE DERIVATIVES .26. SYNTHESIS, ANTITUMOR, MUTAGENIC ACTIVITY AND ANTIMUTAGENIC EFFECT OF IMIDAZOLE-2-CARBALDEHYDE

Hydrazones, N’, N’-dimethylhydrazones, thiocarbon hydrazones, thiosemicarbazones, azines based on imidazole-2-carbaldehyde containing methyl, benzyl and 4-methoxy-3-nitrobenzyl substituents at position I were synthesized and tested for antitumor, mutagenic, and antimutagenic properties.

Related Products of 288-32-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 288-32-4.

Related Products of 288-32-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Khaled, K. F., introduce new discover of the category.

Electrochemical and molecular dynamics simulation studies on the corrosion inhibition of aluminum in molar hydrochloric acid using some imidazole derivatives

The corrosion inhibition and adsorption characteristics of three selected imidazole derivatives namely, 2-amino-4,5-imidazoledicarbonitril (AID), 5-amino-4-imidazolecarboxamide (AIC) and imidazole (IM) on aluminum in 1.0 M HCl was investigated at 25 A degrees C. Measurements were carried out under various experimental conditions using chemical (weight loss), and electrochemical (Tafel polarization and impedance) methods. Molecular dynamics (MD) method and density functional theory were also applied here for theoretical study. Results obtained showed that inhibition efficiency of these compounds increases with increase in their concentrations due to the formation of a surface film on the aluminum surface. Adsorption energy as well as hydrogen bond length calculations showed that AID was the best corrosion inhibitor among the tested imidazole derivatives. Polarization measurements reveal that the selected imidazole derivatives function mainly as cathodic-type inhibitors. Physisorption, followed by chemisorption was proposed as the mechanism for the inhibition process. Adsorption via H-bond formation was also considered here. Results obtained from theoretical study were found to confirm experimental findings.

Related Products of 288-32-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 288-32-4.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, in an article , author is Malhotra, Vineet, once mentioned of 288-32-4, Product Details of 288-32-4.

Substituted imidazole derivatives as novel cardiovascular agents

A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive & bradycardiac responses. Compounds 3b, 3c, 3f & 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50>1000mg/kg with maximum in 2e & 4c (>1200mg/kg). (C) 2010 Elsevier Ltd. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 288-32-4, you can contact me at any time and look forward to more communication. Product Details of 288-32-4.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, in an article , author is Aydogan, Goezde, once mentioned of 288-32-4, Safety of 1H-Imidazole.

Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium

Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, derivatives tested exhibited a greater mutagenic activity in the TA100 strain comparing to the responses in TA 98. In the standard plate incorporation assay, 8 of these substances (80%) were found to be mutagenic for at least one of the two strains in the presence or absence of metabolic activation. Two compounds showed positive results in TA98 and 6 compounds were also mutagenic in TA100 without S9. In the presence of S9 mix, all of the 10 substances were non-mutagenic in TA98, whereas 4 compounds were positive in TA100. The results suggested the mutagenic potentials of the imidazole derivatives particularly inducing the reversion of base-pair substitutions. According to the structure-activity relationships phenyl groups in position 2 with different substituents can confer the mutagenic activity of the tested compounds. Methyl groups in different positions of these phenyl substituents can cause different types of mutations. This mutagenic effect is observed more clearly when the phenyl group is inhibited with a nitro group.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 288-32-4, you can contact me at any time and look forward to more communication. Safety of 1H-Imidazole.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C3H4N2, 288-32-4, Name is 1H-Imidazole, molecular formula is C3H4N2, belongs to imidazoles-derivatives compound. In a document, author is FLORIS, G, introduce the new discover.

PLATINUM(IV) COMPLEXES WITH PURINE OR PYRIMIDINE AND IMIDAZOLE DERIVATIVES

Pt(IV) mixed chloride complexes with purine or pyrimidine and imidazole derivatives have been prepared and characterized. The compounds have general formula [Pt(L1)(L2)Cl4], where L1 = purine (pur) or pyrimidine (pyr) and L2 = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm) or N-propylimidazole (N-PropIm), except for the complex [Pt(pur)(pyr)CI4]. The nitrogen bases act as monodentate ligands coordinated via nitrogen. The far i.r. and electronic reflectance spectra indicate a hexacoordinate geometry. The complexes competitively inhibit lentil amine oxidase, with highest inhibition for [Pt(pur)(N-EtIm)Cl4].

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 288-32-4. COA of Formula: C3H4N2.

Synthetic Route of 288-32-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 288-32-4 as follows.

General procedure: Under an O2 atmosphere, a mixture of 4-methoxyphenylboroic acid (1a, 60.8 mg, 0.40 mmol), imidazole (2a, 13.6 mg, 0.20 mmol), Cu(OAc)2 (3.6 mg, 0.020 mmol), ligand I (3.7 mg, 0.020 mmol), and Triton X-100 (38.8 mg, 0.060 mmol) in H2O (4 mL) was stirred at room temperature for 24 h. The mixture was diluted with brine and extracted with AcOEt (30 mL¡Á3). The organic layer was washed with H2O (10 mL¡Á3) and dried over MgSO4. The solvent was removed under the reduced pressure and the residue was purified by SiO2 column chromatography using AcOEt to give N-(4-methoxyphenyl)imidazole (3aa) (23.0 mg, 66%).

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Inamoto, Kiyofumi; Nozawa, Kanako; Kadokawa, Jun; Kondo, Yoshinori; Tetrahedron; vol. 68; 38; (2012); p. 7794 – 7798;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., name: 1H-Imidazole

General procedure: A mixture of aryl imidazoles (0.5 mmol), arylboronic acid (1 mmol), K2CO3 (1 mmol), C-1 complex (5 mol %, 9.79 mg) in iso-propanol (1.5 mL) was stirred in a 50 mL oven dried round bottomed flask. After the completion of the reaction (monitored by TLC), the mixture was diluted with 20 mL water. The organic part was extracted with diethyl ether (3 20 mL) followed by drying over anhydrous Na2SO4, and the solvent was evaporated under reduced pressure to obtain the crude product. The residue was then purified with column chromatography using methanol/ethyl acetate (1:9) as eluent to afford the desired product. The purity of the compound was confirmed by 1H NMR, 13CNMR, MS, and melting point data. N-Phenyl imidazole (6a): 1H NMR (400 MHz, CDCl3, d ppm) 8.02 (s, 1H), 7.51-7.47 (m, 2H), 7.41-7.37 (m, 3H), 7.26 (s, 1H), 7.21 (s, 1H). 13C NMR (100 MHz, CDCl3, d ppm): 138.1, 135.9, 130.5, 130.1, 127.6, 121.8, 118.5.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gogoi, Ankur; Sarmah, Gayatri; Dewan, Anindita; Bora, Utpal; Tetrahedron Letters; vol. 55; 1; (2014); p. 31 – 35;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1H-imidazole (3 g, 44.1 mmol) was dissolved in 2M NaOH (10.6 g, 265.0 mmol)KI (29.3 g, 176.0 mmol)And I2 (22.4 g, 88.0 mmol) in 100 mL of water,Reaction at room temperature for 3 hours,Dropping 6M dilute hydrochloric acid to adjust the pH of the reaction solution to neutral,Produce a lot of solid,Suction filtration,Ethanol recrystallization,Obtained as an off-white solid,Yield 99.0%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Reference:
Patent; China Pharmaceutical University; Nanjing University; Lai Yisheng; Sun Qirui; Zou Yi; Xu Qiang; Guo Wenjie; Wang Yan; Wang Fang; Li Yuezhen; (23 pag.)CN107501272; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 288-32-4 as follows. Product Details of 288-32-4

Step 4 4-(Imidazol-1-yl)nitrobenzene To a stirred solution of imidazole (34.1 g, 0.50 mol) in DMF (300 ml) under Ar, was added portionwise, over 23 minutes, 60% NaH in oil (20.02 g, 0.50 mol). The mixture was then stirred at room temperature for 18 minutes before adding dropwise, over 40 minutes, a solution of 1-fluoro-4-nitrobenzene (70.62 g, 0.50 mol) in DMF (60 ml). The mixture was then stirred at room temperature overnight. Water (600 ml) was then added and the solid was filtered off, washed with water, then stirred in boiling ethyl acetate (400 ml), allowed to cool and filtered, washing the solid with more ethyl acetate (50 ml), then petroleum ether (250 ml). The filtrate, now containing more solid, was refiltered and washed with petroleum ether. The combined solids were dried in a vacuum desiccator overnight to give 90.14 g (95%) of the title compound as a yellow solid. deltaH (360 MHz, DMSO-d6) 7.59 (1H, t, J=1.1 Hz), 7.97-8.03 (3H, m), 8.38 (2H, d, J=9.2 Hz), 8.52 (1H, t).

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck Sharp & Dohme Ltd.; US6150391; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of imidazole (30 mmol, 2.04 g), potassiumhydroxide (30 mmol, 1.68 g) and dimethyl sulfoxide(10 mL) was stirred for 2 h at room temperature. Afterthat, alkyl bromide (25.0 mmol of 1-bromohexane, 1-bromooctane,1-bromodecane, 1-bromododecane, 1-bromotetradecane,1-bromohexadecane, or 1-bromooctadecane)was dropped in slowly and the mixture was stirred for anadditional 4 h. Upon completion, water (30 mL) was addedto the resulting mixture followed by extraction with chloroform(5 x 30 mL). The combined organic layer wasdried over anhydrous magnesium sulfate and the filtratewas concentrated under reduced pressure. The residue wassubjected to flash chromatography with ethyl acetate aseluent to give N-alkyl imidazole. The respective yields ofN-hexyl imidazole, N-octyl imidazole, N-decyl imidazole,N-dodecyl imidazole, N-tetradecyl imidazole, N-hexadecylimidazole and N-octadecyl imidazole are 84.6, 82.3, 81.2,80.5, 80.4, 79.8 and 79.6 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Reference:
Article; Zhao, Xiaohui; An, Dong; Ye, Zhiwen; Journal of Surfactants and Detergents; vol. 19; 4; (2016); p. 681 – 691;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem